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| 1 | Structural insights into the TRIM family of ubiquitin E3 ligases显示文摘 | Yang Li Han Wu Wei Wu Wei Zhuo Weixiao Liu Yixiao Zhang Minzhang Cheng Ye-Guang Chen Ning Gao Hongtao Yu Linfang Wang Wei Li Maojun Yang | 2014 | Cell Research2014，24，6： | 12 |
| 2 | Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction显示文摘During acute myocardial infarction,endoplasm ic reticulum(ER)stress-induced autophagy and apoptosis have been shown as im portant pathogeneses of myocardial reconstruction.Im portantly,hydrogen sulfide(H2S),as a third endogenous gas signaling molecule,exerts strong cytoprotective effect on anti-ER stress,autophagy regulation and antiapoptosis.Here,we showed that H2 S treatm ent inhibits apoptosis by regulating ER stress-autophagy axis and im proves myocardial reconstruction after acute myocardial infarction.We found that H2S intervention im proved left ventricle function,reduced glycogen deposition in myocardial tissue mesenchyme,and inhibited apoptosis.Moreover,the expressions of fibrosis indicators(Col3a1 and Col1a2),ER stress-related proteins(CHOP and BIP/ERP78),autophagy-related proteins(Beclin and ATG5),apoptosis protein(Bax),as well as fibrosis protein Col4a3bp were all decreased after treatm ent w ith H2 S.H2 S adm inistration also m aintained MMP/TIMP balance.Mechanistically,H2S activated the PI3K/AKT signaling pathway.In addition,H2S treatm ent also reduced the expressions of ER stress-related proteins,autophagy-related proteins,and apoptins in in wtro experiments.Interestingly,activation of ER stress-autophagy axis could reverse the inhibitory effect of H2S on myocardial apoptosis.Altogether,these results suggested that exogenous H2S suppresses myocardial apoptosis by blocking ER stress-autophagy axis,which in turn reverses cardiac rem odeling after myocardial infarction. | Yaling Li Maojun Liu Jiali Yi Xiong Song Xia Zheng Da Liu Sen Wang Chun Chu Jun Yang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 5 |
| 3 | Structure of the intact 14-subunit human cytochrome c oxidase显示文摘 | Shuai Zong Meng Wu Jinke Gu Tianya Liu Runyu Guo Maojun Yang | 2018 | Cell Research2018，28，10： | 5 |
| 4 | Structures of SdrD from Staphylococcus aureus reveal the molecular mechanism of how the cell surface receptors recognize their ligands显示文摘Staphylococcus aureus is the most important Gram-positive colonizer of human skin and nasal passage,causing high morbidity and mortality.SD-repeat containing protein D(SdrD),an MSCRAMM(Microbial Surface Components Recognizing Adhesive Matrix Molecules)family surface protein,plays an important role in S.aureus adhesion and pathogenesis,while its binding target and molecular mechanism remain largely unknown.Here we solved the crystal structures of SdrD N2-N3 domain and N2-N3-B1 domain.Through structural analysis and comparisons,we characterized the ligand binding site of SdrD,and proposed a featured sequence motif of its potential ligands.In addition,the structures revealed for the first time the interactions between B1 domain and N2-N3 domain among B domain-containing MSCRAMMs.Our results may help in understanding the roles SdrD plays in S.aureus adhesion and shed light on the development of novel antibiotics. | Xiao Wang Jingpeng Ge Bao Liu Yulin Hu Maojun Yang | 2013 | Protein & Cell2013，4，4： | 3 |
| 5 | Image Tagging by Semantic Neighbor Learning Using User-Contributed Social Image Datasets显示文摘The explosive increase in the number of images on the Internet has brought with it the great challenge of how to effectively index, retrieve, and organize these resources. Assigning proper tags to the visual content is key to the success of many applications such as image retrieval and content mining. Although recent years have witnessed many advances in image tagging, these methods have limitations when applied to high-quality and large-scale training data that are expensive to obtain. In this paper, we propose a novel semantic neighbor learning method based on user-contributed social image datasets that can be acquired from the Web's inexhaustible social image content. In contrast to existing image tagging approaches that rely on high-quality image-tag supervision, we acquire weak supervision of our neighbor learning method by progressive neighborhood retrieval from noisy and diverse user-contributed image collections. The retrieved neighbor images are not only visually alike and partially correlated but also semantically related. We offer a step-by-step and easy-to-use implementation for the proposed method. Extensive experimentation on several datasets demonstrates that the performance of the proposed method significantly outperforms others. | Feng Tian Xukun Shen Xianmei Liu Maojun Cao | 2017 | Tsinghua Science and Technology2017，22，6： | 2 |
| 6 | Cloning and characterization of miRNAs from maize seedling roots under low phosphorus stress显示文摘 | Zhiming Zhang Haijian Lin Yaou Shen Jian Gao Kui Xiang Li Liu Haiping Ding Guangsheng Yuan Hai Lan Shufeng Zhou Maojun Zhao Shibin Gao Tingzhao Rong Guangtang Pan | 2012 | Molecular Biology Reports2012，，8： | 1 |
| 7 | Application of bifunctional Saccharomyces cerevisiae to remove lead(II) and cadmium(II) in aqueous solution显示文摘 | Yunsong Zhang Weiguo Liu Li Zhang Meng wang Maojun Zhao | 2011 | Applied Surface Science2011，，23： | 1 |
| 8 | Research journey of respirasome显示文摘Respirasome,as a vital part of the oxidative phosphorylation system,undertakes the task of transferring electrons from the electron donors to oxygen and produces a proton concentration gradient across the inner mitochondrial membrane through the coupled translocation of protons.Copious research has been carried out on this lynchpin of respiration.From the discovery of individual respiratory complexes to the report of the high-resolution structure of mammalian respiratory supercomplex I1III2IV1,scientists have gradually uncovered the mysterious veil of the electron transport chain(ETC).With the discovery of the mammalian respiratory mega complex I2III2IV2,a new perspective emerges in the research field of the ETC.Behind these advances glitters the light of the revolution in both theory and technology.Here,we give a short review about how scientists‘see’the structure and the mechanism of respirasome from the macroscopic scale to the atomic scale during the past decades. | Meng Wu Jinke Gu Shuai Zong Runyu Guo Tianya Liu Maojun Yang | 2020 | Protein & Cell2020，11，5： | 1 |
| 9 | UQCRFSIN assembles mitochondrial respiratory complex-Ill into an asymmetric 21-subunit dimer显示文摘 | Shuai Zong Jinke Gu Tianya Liu Runyu Guo Meng Wu Maojun Yang | 2018 | Protein & Cell2018，9，6： | 1 |
| 10 | Hapten design and indirect competitive immunoas-say for parathion determination: correlation with molecularmodeling and principal component analysis显示文摘 | LIU Yihua JIN Maojun GUI Wenjun | 2007 | Analytica Chimica Acta2007，591，2： | 1 |
| 11 | ERT-VR: an immersive virtual reality system for emergency rescue training 显示文摘 | Lei Li Maojun Zhang Fangjiang Xu Shaohua Liu | 2005 | Virtual Reality (S1359-4338)2005，8，3： | 1 |
| 12 | Comparative genomic analyses reveal cis-regulatory divergence after polyploidization in cotton显示文摘Polyploidization has long been recognized as a driver for the evolutionary formation of superior plant traits coupled with gene expression novelty.However,knowledge of the effect of regulatory variation on expression changes following polyploidization remains limited.In this study,we characterized transcriptional regulatory divergence by comparing tetraploid cotton with its putative diploid ancestors.We identified 144,827,99,609,and 219,379 Tn5 transposase-hypersensitive sites(THSs)in Gossypium arboreum,G.raimondii,and G.hirsutum,respectively,and found that the conservation of promoter THSs was associated with coordination of orthologous genes expression.This observation was consistent with analysis of transcription-factor binding sites(TFBS)for 262 known motifs:genes with higher TFBS conservation scores(CS)showed less change than those genes with lower TFBS CS in expression levels.TFBS influenced by genomic variation were involved in the novel regulation networks between transcriptional factors and target genes in tetraploid cotton.We describe an example showing that the turnover of TFBS was linked to expression pattern divergence of genes involved in fiber development(fiber-related genes).Our findings reveal the regulatory divergence of the transcriptional network in cotton after polyploidization and characterizes the regulatory relationships of genes contributing to desirable traits. | Jiaqi You Min Lin Zhenping Liu Liuling Pei Yuexuan Long Lili Tu Xianlong Zhang Maojun Wang | 2022 | The Crop Journal2022，10，6： | 0 |
| 13 | TMCO1是内质网钙离子过载激活的钙离子通道显示文摘钙信号是重要的细胞内离子信号,其在胞内的浓度必须被精确地调控,以达到信号传递的忠实性和准确性。内质网是细胞内的重要钙库,保持内质网(ER)中钙离子浓度的平衡对于触发准确的钙信号和行使正常的细胞功能至关重要。 | Qiao-Chu Wang Qiaoxia Zheng Haiyan Tan Bing Zhang Xiaoling Li Yuxiu Yang Jie Yu Yang Liu Hao Chai Xi Wang Zhongshuai Sun Jiu-Qiang Wang Shu Zhu Fengli Wang Maojun Yang Caixia Guo Heng Wang Qingyin Zheng Yang Li Quan Chen Aimin Zhou 唐铁山 | 2017 | 科学新闻2017，19，4： | 0 |
| 14 | Cloning and Expression of the Serine Carboxypeptidase Gene in Zea mays and Its Antifungal Activity against Rhizoctonia solani显示文摘 | Li Liu Xiujing He Zhiming Zhang Maojun Zhao Jing Wang Haijian Lin Ya'ou Shenl Guangtang Pan | 2013 | Journal of Life Sciences2013，7，2： | 0 |
| 15 | Construction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index显示文摘Dear Editor,The selection of linkers and payloads plays a crucial role in determining the therapeutic indices of antibody–drug conjugates(ADCs).1 Valine–citrulline(Val–Cit)coupled with a self-immolativeρ-aminobenzyl(PAB)spacer as a cleavable dipeptide linker,designated as“VC linker”in this letter,has been popularly used in ADC conjugation.1 However,VC linker is highly hydrophobic2 and,together with hydrophobic payloads at high DARs(drug-toantibody ratios),may turn ADC molecules that have hydrophilic parts in their antibody portions,into aggregation-prone“surfactant-like”structures. | Ting Shao Tianzhi Chen Yuning Chen Xiaoyue Liu Yi-Li Chen Qi Wang Tong Zhu Maojun Guo Hui Li Dianwen Ju Chunhe Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 16 | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase(NAMPT)and their preclinical neuroprotective activity显示文摘The decline of nicotinamide adenine dinucleotide(NAD)occurs in a variety of human pathologies including neurodegeneration.NAD-boosting agents can provide neuroprotective benefits.Here,we report the discovery and development of a class of potent activators(NATs)of nicotinamide phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD salvage pathway.We obtained the crystal structure of NAMPT in complex with the NAT,which defined the allosteric action of NAT near the enzyme active site.The optimization of NAT further revealed the critical role of K189 residue in boosting NAMPT activity.NATs effectively increased intracellular levels of NAD and induced subsequent metabolic and transcriptional reprogramming.Importantly,NATs exhibited strong neuroprotective efficacy in a mouse model of chemotherapy-induced peripheral neuropathy(CIPN)without any overt toxicity.These findings demonstrate the potential of NATs in the treatment of neurodegenerative diseases or conditions associated with NAD level decline. | Hong Yao Minghui Liu Leibo Wang Yumeng Zu Chou Wu Chenyu Li Ruoxi Zhang Haigen Lu Feifei Li Shuang Xi Shuangquan Chen Xuanyu Gu Tianya Liu Jie Cai Shirong Wang Maojun Yang Guo-Gang Xing Wei Xiong Lan Hua Yefeng Tang Gelin Wang | 2022 | Cell Research2022，32，6： | 0 |
| 17 | Multidimensional diversity of bird communities across spatial variation of land cover in Zoige on the eastern Qinghai-Tibetan Plateau显示文摘Background:Spatial variation of land cover can result in the changes of community similarities and biotic homog-enization,whereby the increasing similarity would reduce the adaptive capacity of biotic assemblages to further disturbance,and degenerate ecosystem services they offer.However,it remains scarce to integrate multidimensional diversity for unveiling how variations in land cover may influence the patterns and processes of biotic homogeniza-tion in the Anthropocene.In this study,we examined how spatial variation of land cover could alter taxonomic,phy-logenetic and functional homogenization of bird communities simultaneously in a compound ecosystem of Zoige Marsh on the eastern Qinghai-Tibetan Plateau.Acting as the largest alpine marsh and peatland in the world,Zoige Marsh has undergone great changes in the land cover pattern due to climate change and anthropogenic activities.Methods:We conducted transect surveys for bird communities over six years(2014‒2019)during breeding sea-sons in four main land cover types(meadow,woodland,village and marsh),representing the spatial variation of land covers in the study area.We compared multidimensional diversity(taxonomic,phylogenetic and functional diver-sity)among land covers to assess the effects of spatial variation in land cover type on bird communities,particularly whether this variation has homogenized biotic communities.Results:Bird communities during breeding seasons were different and complementary in the four land covers.Taxonomic,phylogenetic and functional similarities were significantly lower in meadow than in the other three types,i.e.woodland,village and marsh.However,when we controlled for the effects of taxonomic similarities,the pattern of phylogenetic similarities almost reversed,with the highest standardized effect size(SES)phylogenetic similarity in meadow;and we found no significant difference in SES functional similarity among land covers.Conclusions:Our results suggest that spatial variation of land cover can play a crucial role in regulating multiple dimensions of bird diversity in Zoige Marsh.The findings indicate that taxonomic,phylogenetic and functional homogenization of bird communities may differently response to the variation of land covers.It thus highlights not only the relative roles of different land covers in maintaining biodiversity and community structures of birds,but also the urgency of retarding ecosystem degradations on the eastern Qinghai-Tibetan Plateau. | Aichun Xu Maojun Zhong Ke Tang Xiaoyi Wang Chen Yang Haigen Xu Jianfeng Yi Wei Liu Chunlan Zhang Junhua Hu | 2021 | Avian Research2021，12，2： | 0 |
| 18 | Subarachnoid hemorrhage after surgery of the medulla oblongata hemangioblastoma:A case report显示文摘Objectives: To discuss the bleeding mechanisms after removing a medulla oblongata hemangioblastoma. Methods: A 42-year-old male patient was diagnosed with a medulla oblongata hemangioblastoma. Preoperative cranial magnetic resonance imaging, computed tomography angiography and post-surgery computed tomography were completed during clinical procedure. We also reviewed the related literatures. Results: The preoperative computed tomography angiography did not demonstrate any intracranial aneurysm. But, the patient had a fatal subarachnoid hemorrhage with ventricular hemorrhage 4 hours after surgery following the post-surgery computed tomography. Conclusions: Subarachnoid hemorrhage after surgery of the medulla oblongata hemangioblastoma is very rare. Delayed postoperative hemorrhage seems the most reasonable explanation of Subarachnoid hemorrhage in our case. | Xiang Yang Yuekang Zhang Xuesong Liu Maojun Chen | 2016 | Translational Neuroscience and Clinics2016，2，3： | 0 |
| 19 | A Large Acute Gastroenteritis Outbreak Associated with Both Campylobacter coli and Human Sapovirus—Beijing Municipality,China,2021显示文摘Summary What is already known about this topic?Campylobacter is a significant foodborne pathogen that leads to global outbreaks of acute gastroenteritis(AGE)usually affecting less than 30 individuals.Human sapovirus(HuSaV)is an enteric virus responsible for sporadic cases and outbreaks of AGE worldwide.In a study conducted in Beijing,HuSaV detection ranked second after norovirus.What is added by this report?We present a discussion of the first large-scale outbreak of AGE caused by both Campylobacter coli(C.coli)and HuSaV.The outbreak involved a total of 996 patients and exhibited two distinct peaks over a period of 17 days.Through case-control studies,we identified exposure to raw water from a secondary water supply system as a significant risk factor.Among 83 patients,49 samples tested positive for C.coli,39 samples tested positive for HuSaV,and 27 samples tested positive for both pathogens using real-time polymerase chain reaction detection.Furthermore,whole-genome sequencing of 17 C.coli isolates obtained from 17 patients revealed that all isolates belonged to a highly clonal strain of C.coli.What are the implications for public health practice?Outbreaks of AGE resulting from multiple pathogen infections warrant increased attention.This report emphasizes the significance of ensuring the safety of drinking water,particularly in secondary supply systems. | Lin Zou Ying Li Guilan Zhou Zhenzhou Huang Changyan Ju Chunyan Zhao Xiang Gao Bojun Zhen Ping Zhang Xiaochen Guo Jing Zhang Yang Zhang Bo Liu Shaolei Zhou Aixia Yan Ying Kang Yanchun Wang Hongmei Ma Xiaohui Li Maojun Zhang | 2023 | China CDC weekly2023，5，52： | 0 |
| 20 | Vaccination inhibits TLR2 transcription via suppression of GR nuclear translocation and binding to TLR2 promoter in porcine lung infected with Mycoplasma hyopneumoniae显示文摘Toll-like receptors(TLRs)and glucocorticoid receptor(GR)act as effectors of innate immune system and neuroendocrine system,respectively.The crosstalk between these two receptors is important to maintain homeostasis during immune response.It is well known that vaccination can boost adaptive immune responses to specific pathogens.However,it remains elusive whether and | Zhiyuan Sun Maojun Liu Xian Li Huafeng Zou Guoqing Shao Ruqian Zhao | 2012 | 畜牧与兽医2012，44，S1： | 0 |
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