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| 1 | Anti-lipid droplets accumulation effect of Annona montana(mountain soursop)leaves extract on differentiation of preadipocytes显示文摘The Annona genus is a member of Annonaceae,one of the largest families of plants across tropical and subtropical regions.This family has been used in several ethnomedicinal practices to treat a multitude of human diseases.However,the molecular mechanism underlying its effect on the lipid droplet formation and on the expression of adipogenic markers of this plant remain to be investigated.In this study,we examined whether the extracts from the aerial part of Annona montana affect in vitro differentiation of preadipocytes.For our investigations,both mouse embryo fibroblast 3T3-L1 and normal human primary subcutaneous preadipocytes were incubated with Annona montana extracts(-and its subfractions-)and then analyzed on preadipocyte differentiation,lipid content,lipid droplet size and number,the expression of adipogenic-specific transcriptional factors,as well as cell survival.From our examinations,we found the Annona montana ethyl acetate extract to exhibit a potent inhibitory effect on adipogenesis,without affecting cell survival,in a dose-dependent manner.Such inhibitory effects included a significant decrease in the accumulation of lipid content by both a dramatic reduction of size and number of lipid droplets.This extract strongly attenuated the expression of PPARγand HMGB2.It also inhibited the expression of CEBPα,FAS,and Akt without influencing Erk1/2 activities.Our findings suggest that specifically,the Annona montana ethyl acetate extract has a prominent inhibitory effect in cellular pathways of adipocyte differentiation by modulating specific gene expression,which is known to perform a pivotal role during adipogenesis. | IVY LEUNG MARIA-LUISA VEISAGA MARGARITA ESPINAL WEI ZHANG ROBERT BARNUM MANUEL ALEJANDRO BARBIERI | 2022 | BIOCELL2022，46，3： | 1 |
| 2 | 静谧黑白间显示文摘对设计师而言,黑白色既是一对最简洁、最朴素的色彩,也是最复杂、最神奇的设计元素。黑色沉稳,白色轻灵,虽然不如彩色那么绚丽,却给人一种高贵的气质。以其为基础,加之人类的智慧,展现出别样的魅力与优雅神韵。黑与白的经典搭配褪去了缤纷的色彩,产生简洁、和谐且富有美感的视觉效果,将五彩缤纷、千变万化的繁杂生态概括于一体,将简约风尚化身为低调的奢华,内敛而不失深刻,且历久弥新,令人回味无穷。"天为阳,地为阴;阳为白,阴为黑。日月交替,阴阳转换。"古老的谚语,将世间万物归纳到对立统一的黑白之中。黑白本身就是一门艺术,它源远流长,几乎与人类文明同步发展,经历了五千年来的文化沉淀。在迷离的色彩世界中,黑与白以其独有的简洁、单纯、朴素与概括为各个时代的艺术家所青睐。 | Anatology Bao-nghi Droste Fanny Richard Florian Kallus Sebastian Schneider House of Hackney &klevering Manuel Barbieri molo design NikaZupanc Piet Boon Rometti Sylvie Renoux-Editeur Néazoé Simon Stevens Tina Frey 伏平 范嘉苑 | 2014 | 现代装饰(家居)2014，0，12： | 0 |
| 3 | A hypothesis for a novel role of RIN1-the modulation of telomerasefunction by the MAPK signaling pathway显示文摘Cancerous cells display abnormalities in the signal transduction pathways responsible for responding to extracellular growth factors,or mitogens.Mutations that alter proteins involved in these types of pathways can lead to inappropriate or unregulated cell growth,and therefore predispose the cell to become malignant.The critical role of the Ras/mitogen-activated protein kinase(MAPK)pathway in transducing growth signals to the interior of the cell and subsequently stimulating cell growth and proliferation is underscored by the fact that roughly one quarter of all human tumors contain mutant forms of Ras proteins.A particular focus on the signaling and membrane trafficking adaptor protein known as Ras interference 1(RIN1)will reveal how this protein can potentially play a significant role in the development of the cancerous phenotype in certain cell types.Of equal interest is the possible connection between the Ras/MAPK pathway,and subsequent expression and enzymatic activity of telomerase–a key enzyme known to be overexpressed in roughly 85%of all cancers.RIN1 is a 783 amino acid(84 kDa)cytosolic protein that is involved in key steps of growth factor receptormediated endocytosis and can potentially moderate signaling through the MAPK pathways.RIN1,with its unique ability to compete directly with Raf for activation by Ras,could potentially influence signaling through more than one of the MAPK pathways.If so,RIN1 may then be able to exert a precise and selective effect on the downstream signal(s)of a MAPK target such as telomerase. | PATRIC HAMBLETON MANUEL ALEJANDRO BARBIERI | 2020 | BIOCELL2020，44，4： | 0 |
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