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| 1 | pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging显示文摘The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable sensing.However,few contrast agents are available that can specifically respond to intricate biological environments,and which are biodegradable and biocompatible.Herein,we in troduce a new class of pH-sensitive orga nic photoacoustic con trast age nt that operates in the second NIR window(NIR-II,960-1,700 nm),which is derived from the self-assembled charge-transfer nanocomplex(CTN)by 3,3',5,5'-tetramethylbenzidine(TMB)and its dication structure(TMB++).The unique NIR-ll-responsive CTN can specifically respond to pH change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment(e.g.at pH5)in mice with higher signal-to-noise ratio.The CTN is biodegradable under physiological conditions(e.g.pH 7.4),which alleviates the biosafety concern of nan oparticle accumulati on in vivo.These results clearly show the pote ntial of the TMB/TMB++-based CTN as a promisi ng pH-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region. | Zhimin Wang Paul Kumar Upputuri Xu Zhen Ruochong Zhang Yuyan Jiang Xiangzhao Ai Zhijun Zhang Ming Hu Zhenyu Meng Yunpeng Lu Yuanjing Zheng Kanyi Pu Manojit Pramanik Bengang Xing | 2019 | Nano Research2019，12，1： | 3 |
| 2 | Medicinal chemistry approaches to the inhibition pf dipeptidyl peptidase-4 for the treatment of type 2 diabetes 显示文摘 | Shrikanth H Havale Manojit Pal | 2009 | Bioorg Med Chem2009，17，5： | 1 |
| 3 | Synthesis of (S)-1-(2- chloroacetyl) pyrrolidine-2-carbonitrile: a key intermediate for dipeptidyl peptidase IV inhibitors 显示文摘 | Santosh KS Narendra M Manojit P | 2008 | Beilstein J Org Chem2008，4，20： | 1 |
| 4 | Simple and fast support vector ma- chine (SVM) toolbox显示文摘 | Loosli Galic Canu Stphane Vishwanathan S V N Smola Alexander J Chattopadhyay Manojit | 2005 | Revue dlntelligenee Artificielle2005，1945，： | 1 |
| 5 | A rapid and direct access to symmetrical/unsymmetrical 3,4-diarylmaleimides and pyrrolin-2-ones显示文摘 | Manojit Pal Koteswar Rao Yeleswarpu | 2004 | Tetrahedron2004，60，： | 1 |
| 6 | Effects of predation on host pathogen dynamics in SIR models 显示文摘 | Manojit Robert D H | 2008 | Theoretical Population Biol- ogy2008，73，： | 1 |
| 7 | 脂质体内金纳米星的原位合成以及在药物释放和光声造影上的应用(英文)显示文摘本文通过在脂质体内还原金的前体HAuCl_4原位合成了金纳米星.这种设计跟常用的在脂质体内装载金纳米球的方法相比,优点是方便快捷的同时实现了金纳米材料的形成和装载.通过改变实验条件,合成的金纳米星具有可控的尺寸,以及在可见区到近红外区之间的可控吸收光谱.作为一个例子,我们在脂质体内合成了最大吸收在803 nm的金纳米星.这种材料具有温度敏感性,在近红外区可以产生比血液好1.5倍的光声造影信号.当我们把抗癌药物阿霉素装载到这种脂质体内时,近红外区的激光照射可以在10秒内触发药物100%的释放.相对应的,不含纳米星的脂质体在同等条件下只能释放10%的药物,也不具备光声造影的信号增强.最后,我们在癌细胞内测试了该脂质体的疗效,初步验证了该体系的应用前景. | Malathi Mathiyazhakan Paul Kumar Upputuri Kathyayini Sivasubramanian Ashish Dhayani Praveen Kumar Vemula 邹培超 浦侃裔 杨诚 Manojit Pramanik 徐臣杰 | 2016 | Science China Materials2016，59，11： | 1 |
| 8 | A simple denoising algorithm using wavelet transform显示文摘 | Manojit R Kumar V Kulakami B D | 1999 | American Institute of Chemical Engineers Journal1999，45，11： | 1 |
| 9 | Synthesis of(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile:a key intermediate for dipeptidyl peptidaseⅣinhibitors显示文摘 | Santosh K S Narendra M Manojit P | 2008 | Beilstein Journal of Organic Chemistry2008，4，： | 1 |
| 10 | A simple denoising algorithm using wavelet transform显示文摘 | Kumar V Kulakarni B D | 1999 | American institute of chemical engineers journal1999，45，11： | 1 |
| 11 | A high speed parallel synthesis of 1,2-diaryl-1-ethanones via a clean-chemistry C-C bond formation reaction显示文摘 | Venugopal Rao Veeramaneni Manojit Pal Koteswar Rao Yeleswarapu | 2003 | Tetrahedron2003，59，18： | 1 |
| 12 | Novel imidazophenoxazine-4-sulfonamides: Their synthesis and evaluation as potential inhibitors of PDE4显示文摘 | Seelam Venkata Reddy Gangula Mohan Rao Baru Vijaya Kumar Chandana L.T. Meda Girdhar Singh Deora K. Shiva Kumar Kishore V.L. Parsa Manojit Pal | 2013 | Bioorganic & Medicinal Chemistry2013，，7： | 1 |
| 13 | A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging显示文摘 | Dipanjan P Manojit P Angana S | 2010 | J Nanosci Nanotechnol2010，10，： | 1 |
| 14 | Medicinal chemistry ap- proaches to the inhibition of dipeptidyl pepfidase-4 for the treatment of type 2 diabetes 显示文摘 | Shrikanth H H Manojit P | 2009 | Bioorg Med Chera2009，17，： | 1 |
| 15 | Design and evaluation of a novel breast cancer detection system combining both thermoacoustic(TA)and photoacoustic(PA)tomography显示文摘 | Manojit Pramanik Geng Ku Changhui Li | 2008 | Med Phys2008，35，6： | 1 |
| 16 | Synthesis of (S) -1 - (2chloroacetyl) pyrrolidine-2-carbonitrile: a key intermediate for dipeptidyl peptidase IV inhibitors 显示文摘 | Santosh KS Narendra M Manojit P | 2008 | BeiL~tein J Org Chem2008，4，20： | 1 |
| 17 | Effects of predation on ihost-pathogen dynamics in SIR Models显示文摘 | MANOJIT ROY ROBERT D HOLT | 2008 | Theoretical Population Biology2008，73，3： | 1 |
| 18 | Synthesis of( S)-I- ( 2-ehloroaeetyl ) pyrrolidine-2-earbonitrile : a key interme- diate for dipeptidyl peptidase IV inhibitors 显示文摘 | Santosh K S Narendra M Manojit P | 2008 | Beilstein J Org Chem2008，4，20： | 1 |
| 19 | Palladium mediated stereospecific s~lthesis of 3-enynyl substituted thioflavones/fla- vones 显示文摘 | MANOJIT P KARUPPASAMYN P KARUPPASAMY P | 2004 | Tetrahedron Letters2004，45，： | 1 |
| 20 | A high speed parallel synthesis of 1,2-diaryl-1-ethanones via a clean-chemistry C-C bond formation reaction显示文摘 | Venugopal R V Manojit P | 2003 | Tetrahedron2003，，： | 1 |
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