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| 1 | Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals:From experimental models to clinical trials显示文摘Chemoprevention is one of the cancer prevention approaches wherein natural/synthetic agent(s) are prescribed with the aim to delay or disrupt multiple pathways and processes involved at multiple steps, i.e., initiation, promotion, and progression of cancer. Amongst environmental chemopreventive compounds, diet/beverage-derived components are under evaluation, because of their long history of exposure to humans, high tolerability, low toxicity, and reported biological activities. This compilation briefly covers and compares the available evidence on chemopreventive efficacy and probable mechanism of chemoprevention by selected dietary phytochemicals(capsaicin, curcumin, diallyl sulphide, genistein, green/black tea polyphenols, indoles, lycopene, phenethyl isocyanate, resveratrol, retinoids and tocopherols) in experimental systems and clinical trials. All the dietary phytochemicals covered in this review have demonstrated chemopreventive efficacy against spontaneous or carcinogen-induced experimental tumors and/or associated biomarkers and processes in rodents at several organ sites. The observed anti-initiating, anti-promoting and anti-progression activity of dietary phytochemicals in carcinogen-induced experimental models involve phytochemical-mediated redox changes, modulation of enzymes and signaling kinases resulting to effects on multiple genes and cell signaling pathways. Results from clinical trials using these compounds have not shown them to be chemopreventive. This may be due to our:(1) inability to reproduce the exposure conditions, i.e., levels, complexity, other host and lifestyle factors; and(2) lack of understanding about the mechanisms of action and agent-mediated toxicity in several organs and physiological processes in the host. Current research efforts in addressing the issues of exposure conditions, bioavailability, toxicity and the mode of action of dietary phytochemicals may help address the reason for observed mismatch that may ultimately lead to identification of new chemopreventive agents for protection against broad spectrum of exposures. | Girish B Maru Rasika R Hudlikar Gaurav Kumar Khushboo Gandhi Manoj B Mahimkar | 2016 | World Journal of Biological Chemistry2016，7，1： | 2 |
| 2 | Decay and half-life period of online citations cited in open access journals 显示文摘 | Sampath Kumar B Manoj Kumar K | 2012 | The International Information&Library Review2012，，： | 1 |
| 3 | Mechanisms of material removal during high temperature fretting of TiCN-Ni based cermets显示文摘 | MANOJ KUMAR B V BASU B | 2008 | International Journal of Refractory Metals and Hard Materials2008，26，6： | 1 |
| 4 | Cra- ter wear mechanisms of Ti(C, N)-Ni-WC cermets during dry machining 显示文摘 | Manoj Kumar B V Ram Kumar J Basu Bikramjit | 2007 | International Journal of Refractory Metals & Hard Materials2007，25，5： | 1 |
| 5 | Low-cost adsorbents from bio-waste for the removal of dyes from aqueous solution显示文摘 | Manoj Kumar Reddy P Mahammadunnisa Sk Ramaraju B | 2013 | Environ Sci Pollut Res2013，20，6： | 1 |
| 6 | Multiobjective particle swarm algorithm with fuzzy clustering for electrical power dispatch显示文摘 | Shubham Agrawal Panigrahi B K Manoj Kumar Tiwari | 2008 | IEEE Transactions on Evolutionary Computation2008，12，5： | 1 |
| 7 | Crater wear mechanisms of TiCN-Ni-WC cermets during dry machining 显示文摘 | Manoj Kumar B V Ram Kumar J Basu B | 2007 | International Journal of Refractory Metals and Hard Materials2007，25，： | 1 |
| 8 | Mechanisms of Mate- rial Removal during High Temperature Fretting of TiCN- Ni Based Cermets显示文摘 | Manoj Kumar B V Bikramjit Basu | 2008 | International Journal of Refractory Metals and Hard Materials2008，26，6： | 1 |
| 9 | Fretting wear study on Ti-Ca-P biocomposite in dry and simulated body fluid显示文摘 | Karanjai M Manoj Kumar B V Sundaresan R | 2008 | Mater Sci Eng A2008，475，： | 1 |
| 10 | Crater wear mechanisms of TiCN-Ni-WC cermets during dry ma-chining显示文摘 | Manoj Kumar B V Ram Kumar J Bikramjit Basu | 2007 | Int J Refractory Metals Hard Mater2007，25，： | 1 |
| 11 | The Role of Tribochemistry on Fretting Wear of Mg-SiC Particulate Composites显示文摘 | Manoj Kumar B V Bikramjit Basu Murthy V S R | 2005 | Composites2005，36，： | 1 |
| 12 | Elec- trochemical pretreatment of distillery waste water using alu- minum electrode显示文摘 | Krishna B M Usha N Murthy Manoj Kumar B | 2010 | J Appl Electrochem2010，40，3： | 1 |
| 13 | Processing of polysiloxane-de- rived porous ceramics:a review显示文摘 | Kumar Manoj B V Kim Youngwook | 2010 | Sci Technol Adv Mater2010，11，4： | 1 |
| 14 | RT-MuPAC:A new multi-power architecture for voice cellular networks显示文摘 | KUMAR A K J B S Manoj b C Siva Ram Murthy | 2005 | Computer Networks2005，47，： | 1 |
| 15 | The role of tribochemistry on fretting wear of Mg-SiC particulate composites 显示文摘 | B V Manoj Kumar Bikramjit Basu V S R Murthy | 2005 | Composites Part A2005，36，： | 1 |
| 16 | Electrochemical behavior of TICN-Ni-based cermets 显示文摘 | MANOJ KUMAR B V BALASUBRAMANIAM R BASU B | 2007 | Journal of the American Ceramic Society2007，90，1： | 1 |
| 17 | Crater wear mechanisms of TiCN-Ni-WC cermets during dry machining 显示文摘 | Manoj Kumar B V Kumar J R Basu B | 2007 | International Journal of Refractory Metals and Hard Materials2007，25，56： | 1 |
| 18 | Electrochemical behavior of TiCN-Ni-based cermets 显示文摘 | MANOJ KUMAR B V BALASUBRAMANIAM R BASU B | 2007 | Journal of the American Ceramic Society2007，90，1： | 1 |
| 19 | The role of tribochemistry on fretting wear of Mg-SiC particulate composites显示文摘 | Manoj B V Kumar Bikramjit Basu | 2005 | Compositesm2005，36，： | 1 |
| 20 | Pegylated interferon alfa-2b plus ribavirin for treatment of chronic hepatitis C显示文摘AIM: To study the safety and efficacy of pegylated interferon alfa-2b, indigenously developed in India, plus ribavirin in treatment of hepatitis C virus(HCV). METHODS: One-hundred HCV patients were enrolled in an open-label, multicenter trial. Patients were treated with pegylated interferon alfa-2b 1.5 μg/kg per week subcutaneously plus oral ribavirin 800 mg/d for patients with genotypes 2 and 3 for 24 wk. The same dose of peginterferon plus weight-based ribavirin(800 mg/d for ≤ 65 kg; 1000 mg/d for > 65-85 kg; 1200 mg/d for > 85-105 kg; 1400 mg/d for > 105 kg body weight) was administered for 48 wk for patients with genotypes 1 and 4. Serological and biochemical responses of patients were assessed.RESULTS: Eighty-two patients(35 in genotypes 1 and 4 and 47 in 2 and 3), completed the study. In genotype 1, 25.9% of patients achieved rapid virologic response(RVR): while the figures were 74.1% for early virologic response(EVR) and 44.4% for sustained virologic response(SVR). For genotypes 2 and 3, all patients bar one belonged to genotype 3, and of those, 71.4%, 87.5%, and 64.3% achieved RVR, EVR, and SVR, respectively. In genotype 4, 58.8%, 88.2%, and 52.9% of patients achieved RVR, EVR, and SVR, respectively. The majority of patients attained normal levels of alanine aminotransferase by 4-12 wk of therapy. Most patients showed a good tolerance for the treatment, although mild-to-moderate adverse events were exhibited; only two patients discontinued the study medication due to serious adverse events(SAEs). Eleven SAEs were observed in nine patients; however, only four SAEs were related to study medication.CONCLUSION: Peginterferon alfa-2b, which was developed in India, in combination with ribavirin, is a safe and effective drug in the treatment of HCV. | PN Rao Abraham Koshy Jacob Philip Narayanan Premaletha Joy Varghese Krishnasamy Narayanasamy Samir Mohindra Nitin Vikas Pai Manoj Kumar Agarwal Ashokna Konar Hasmukh B Vora | 2014 | World Journal of Hepatology2014，6，7： | 0 |
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