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| 1 | Robotic surgery for rectal cancer: A systematic review of current practice显示文摘AIM: To give a comprehensive review of current litera-ture on robotic rectal cancer surgery.METHODS: A systematic review of current literature via PubMed and Embase search engines was per-formed to identify relevant articles from january 2007 to november 2013. The keywords used were: 'robotic surgery', 'surgical robotics', 'laparoscopic computer-assisted surgery', 'colectomy' and 'rectal resection'. RESULTS: After the initial screen of 380 articles, 20 pa-pers were selected for review. A total of 1062 patients(male 64.0%) with a mean age of 61.1 years and body mass index of 24.9 kg/m2 were included in the review.Out of 1062 robotic-assisted operations, 831(78.2%) anterior and low anterior resections, 132(12.4%) in-tersphincteric resection with coloanal anastomosis, 98(9.3%) abdominoperineal resections and 1(0.1%) Hart-mann's operation were included in the review. Robotic rectal surgery was associated with longer operative time but with comparable oncological results and anastomotic leak rate when compared with laparoscopic rectal surgery. CONCLUSION: Robotic colorectal surgery has con-tinued to evolve to its current state with promising re-sults; feasible surgical option with low conversion rate and comparable short-term oncological results. The challenges faced with robotic surgery are for more high quality studies to justify its cost. | Tony Wing Chung Mak Janet Fung Yee Lee Kaori Futaba Sophie Sok Fei Hon Dennis Kwok Yu Ngo Simon Siu Man Ng | 2014 | World Journal of Gastrointestinal Oncology2014，6，6： | 16 |
| 2 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 3 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 4 | Efficient and rapid generation of induced pluripotent stem :ells using an alternative culture medium显示文摘 | Xiao-yang Zhao Wei Li Zhuo Lv Lei Liu Man Tong Tang Hai Jie Hao Chang-long Guo Xia ng Wang Liu Wang Fanyi Zeng Qi Zhou | 2010 | Cell Research2010，20，3： | 9 |
| 5 | Multi-limb necrotizing fasciitis in a patient with rectal cancer显示文摘引起坏死筋膜炎是破坏软织物感染影响扁带和下的软纸巾。文学评论识别了几个相关风险因素,包括恶意,酒精中毒,营养不良,糖尿病,男性和老年。仅仅在与颜色描述它的稀罕协会的文学有贫乏的病案报告表面的恶意。所有出版的格被归因于在会阴的区域上导致引起坏死筋膜炎的肠穿孔。孤立上面或下肢疾病很少被识别。同时上面并且在颜色的下肢感染表面的癌症病人从来没在文学被描述过。我们与内在的非穿孔的直肠的癌在一个病人报导多手足引起坏死筋膜炎的一个不平常的案例。 | Shirley Yuk Wah Liu Simon Siu Man Ng Janet Fung Yee Lee | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 6 | Structures of Textile-apparel Supply Chain: Concepts and Cases显示文摘In recent years, supply chain management (SCM) has been in popularity as a new management philosophy for all industries, including textile and apparel industries. The textile-apparel supply chain is relatively complex because it encompasses many participants such as yarn manufa-cturers, fabric manufacturers, garment manufacturers and retailers. Although many scholars are engaged in rese-arching SCM in textile and apparel industries, a systematic classification of textile-apparel chain does not exist. The paper proposes three types of textile-apparel chain, nominated vertical integration chain, traditional sourcing chain and 3P-hub (third party as the hub) chain. Different coordinators exist in different types of chain. Three Hong Kong headquartered companies, Esquel Group, TAL Apparel Ltd., and Li & Fung (Trading) Ltd. are used as cases responding to each type of the structures respectively. | 曹宁 张志明 Kin Man To Chester Keng Po Ng Roger | 2005 | Journal of Donghua University(English Edition)2005，22，2： | 3 |
| 7 | Graft Injury in Relation to Graft Size in Right Lobe Live Donor Liver Transplantation: A Study of Hepatic Sinusoidal Injury in Correlation With Portal Hemodynamics and Intragraft Gene Expression显示文摘 | Kwan Man Sheung-Tat Fan Chung-Mau Lo Chi-Leung Liu Peter Chin-Wan Fung Ting-Bo Liang Terence Kin-Wah Lee Steven Hung-Teng Tsui Irene Oi-Lin Ng Zhi-Wei Zhang John Wong | 2003 | Annals of Surgery2003，，2： | 3 |
| 8 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 9 | Ouabain facilitates cardiac differentiation of mouse embryonic stem cells through ERK1/2 pathway显示文摘 | Yee-ki LEE Kwong-man NG Wing-hon LAI Cornelia MAN Deborah K LIEU Chu-pak LAU Hung-fat TSE Chung-wah SIU | 2011 | Acta Pharmacologica Sinica2011，32，1： | 2 |
| 10 | miR-130b Promotes CD133 + Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1显示文摘 | Stephanie Ma Kwan Ho Tang Yuen Piu Chan Terence K. Lee Pak Shing Kwan Antonia Castilho Irene Ng Kwan Man Nathalie Wong Ka-Fai To Bo-Jian Zheng Paul B.S. Lai Chung Mau Lo Kwok Wah Chan Xin-Yuan Guan | 2010 | Cell Stem Cell2010，，： | 2 |
| 11 | 天然气分散制氢的技术经济分析(英文)显示文摘It is well established that hydrogen has the potential to make a significant contribution to the world energy production.In U.S.,majority of hydrogen production plants implement steam methane reforming(SMR) for centralized hydrogen production.However,there is a wide lack of agreement on the nascent stage of using hydrogen as fuel in vehicles industry because of the difficulty in delivery and storage.By performing technological and economic analysis,this work aims to establish the most feasible hydrogen production pathway for automotives in near future.From the evaluation,processes such as thermal cracking of ammonia and centralized hydrogen production followed by bulk delivery are eliminated while on-site steam reforming of methanol and natural gas are the most technologically feasible options.These two processes are further evaluated by comprehensive economic analysis.The results showed that the steam reforming(SR) of natural gas has a shorter payback time and a higher return on investment(ROI) and internal rate of return(IRR).Sensitivity analysis has also been constructed to evaluate the impact of variables like NG feedstock price,capital of investment and operating capacity factor on the overall production cost of hydrogen.Based on this study,natural gas is prompted to be the most economically and technologically available raw material for short-term hydrogen production before the transition to renewable energy source such as solar energy,biomass and wind power. | LUK Ho Ting LEI Ho Man NG Wai Yee LAM Koon Fung | 2012 | Chinese Journal of Chemical Engineering2012，20，3： | 2 |
| 12 | Tissue-specific pathways for estrogen regulation of ovarian cancer growth and metastasis 显示文摘 | Spillman MA Manning NG Dye WW | 2010 | Cancer Res2010，70，21： | 1 |
| 13 | A pilot controlled trial of a combination of dense cranial electroacupuncture stim- ulation and body acupuncture for post-stroke depression 显示文摘 | Man SC Hung BH Ng RM | 2014 | BMC Complement Altern Med2014，19，14： | 1 |
| 14 | The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers显示文摘 | Spoelstra NS Manning NG Higashi Y | 2006 | Cancer Res2006，66，7： | 1 |
| 15 | Preparation of MgO and Fe nanostructure in Mg matrix composite by reaction sintering显示文摘 | MAN G LANG J NG D H L | 2005 | Composites Science and Technology2005，36，9： | 1 |
| 16 | Clinicopathological significance of homeopretein Sixl in hepatoeellular carcinoma 显示文摘 | Ng KT Man K Sun CK | 2006 | Br J Cancer2006，95，8： | 1 |
| 17 | Liver transplantation in rats using small-for-size grafts:a study of hemodynamic and morphological changes显示文摘 | Man K Lo CM Ng IOL | 2001 | Arch Surg2001，136，： | 1 |
| 18 | The use of atmospheric pressure plas- ma treatment on enhancing the pigment application to cotton fab- ric显示文摘 | Man W S Kan C W Ng S P | 2014 | Vacuum2014，99，1： | 1 |
| 19 | The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2显示文摘 | Carmen Chak–Lui Wong Chun–Ming Wong Edmund Kwok–Kwun Tung Sandy Leung–Kuen Au Joyce Man–Fong Lee Ronnie Tung–Ping Poon Kwan Man Irene Oi–Lin Ng | 2011 | Gastroenterology2011，，1： | 1 |
| 20 | In situ formation of titanium carbide using titanium and carbon-nanotube powders by laser cladding显示文摘 | SAVALANI M M NG C C Li Q H MAN H C | 2012 | Applied Surface Science2012，258，7： | 1 |
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