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| 1 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 14 |
| 2 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 3 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 4 | Formation of an active elective barrier at Al/semiconductor interface : a novel approach in corrosion prevention 显示文摘 | Jain F C Rosato J J Mani G | 1986 | Corrosion1986，42，： | 1 |
| 5 | Vascular glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures显示文摘 | Silverman W F Krum J M Mani N | 1999 | Neuroscience1999，90，4： | 1 |
| 6 | Gall bladder and extrahepatic bile duct lymphomas:clinicopathological observations and biological impli- cations显示文摘 | Mani H Climent F Colomo L | 2010 | Am J Surg Patho12010，34，9： | 1 |
| 7 | TGA study examining the effect of pressure and peak temperature on biochar yield during pyrolysis of two-phase olive mill waste显示文摘 | Joan J Manyà F Xavier Roca J Francisco Perales | 2012 | Journal of Analytical and Applied Pyrolysis2012，103，： | 1 |
| 8 | In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin显示文摘 | Ghasemi Tahrir F Ganji F Mani AR | 2016 | Drug Deliv2016，23，3： | 1 |
| 9 | Orodental phenotype and genotype findings in all subtypes of hypophosphatasia显示文摘 | Reibel A Manière MC Clauss F | 2009 | Orphanet J Rare Dis2009，4，： | 1 |
| 10 | Influence of proteins on the hydrothermal gasification and liquefaction of biomass (2): Model compounds 显示文摘 | Kruse A Mani P Spieler F | 2006 | Industrial & Engineering Chemistry Research2006，6，1： | 1 |
| 11 | XRCC1 stimulates poly- nucleotide kinase by enhancing its damage discrimination and dis- placement from DNA repair intermediates 显示文摘 | Mani RS Fanta M Karimi-Busheri F | 2007 | J Biol Chem2007，282，28： | 1 |
| 12 | Total hip replacement in congenital dislocation and dysplasia of the hip显示文摘 | Crowe J F Mani VJ Ranawat CS | 1979 | The Journal of bone and joint surgery1979，61，1： | 1 |
| 13 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 1 |
| 14 | Total hip replace- ment in congenital dislocation and dysplasia of the hip显示文摘 | CROWE J F MANI V J RANAWAT C S | 1979 | J Bone Joint Surg Am1979，61，1： | 1 |
| 15 | The non-obese diabetic (NOD) mouse:an animal model for autoimmune thyroiditis显示文摘 | Many M C Maniratunga S Denef J F | 1996 | Exp Clin Endocrinol Diabetes1996，104，3： | 1 |
| 16 | Iodine induced thyroid inhibition and cell necrosis:two consequences of the same free radical mediated mechanism显示文摘 | Denef J F Many M C Vandenhove M F | 1996 | Mol Endocrinol1996，121，1： | 1 |
| 17 | Functional specific binding of testosterone to Schistosoma haematobium 28--kilodahon glutathione Strartsferase显示文摘 | Remoue F Mani J C Pugniere M | 2002 | Infect Immun2002，70，2： | 1 |
| 18 | CPI:Constraints-Preserving Inlining Algorithm for Mapping XML DTD To Relational Schema显示文摘 | D Lee M Mani F Chiu | 2001 | J Data & Knowledge Engineering(DKE)2001，39，1： | 1 |
| 19 | Cell necrosis and apoptosis are differentially regulated during goitre de?velopment and iodine-induced involution显示文摘 | MutakuJ F PomaJ F Many M C | 2002 | J Endocri?nol2002，172，2： | 1 |
| 20 | Novel non-aqueous amine solvents for reversible CO2 capture 显示文摘 | Barzagli F Lai S Mani F | 2014 | Energy Procedia2014，63，： | 1 |
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