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| 1 | Determination of drug,excipients and coating distribution in pharmaceutical tablets using NIR-CI显示文摘The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition).In this work,the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been obtained.In addition,the same NIR-CI allowed the coating thickness and its surface distribution to be quantified.Images were processed to extract the target data and calibration models constructed using the Partial Least Squares (PLS) algorithms.The concentrations of Active Pharmaceutical Ingredient (API) and excipients obtained for uncoated cores were essentially identical to the nominal values of the pharmaceutical formulation.But the predictive ability of the calibration models applied to the coated tablets decreased as the coating thickness increased. | Anna Palou Jordi Cruz Marcelo Blanco Jaume Tomàs Joaquín de los Ríos Manel Alcalà | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 4 |
| 2 | Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?显示文摘Hepatic glycogenosis(HG) is characterized by excessive glycogen accumulation in hepatocytes and represents a hepatic complication of diabetes that particularly occurs in patients with longstanding poorly controlled type 1 diabetes(T1D). HG has been reported to be a very rare disease, although it is believed to be extremely underdiagnosed because it is not possible to distinguish it from non-alcoholic fatty liver disease(NAFLD) unless a liver biopsy is performed. In contrast to HG, NAFLD is characterized by liver fat accumulation and is the more likely diagnosis for patients with type 2 diabetes and metabolic syndrome. The pathogenesis of HG involves the concomitant presence of insulin and excess glucose, which increases glycogen storage in the liver. HG is characterized by a transient elevation in liver transaminases and hepatomegaly. Differentiating between these two conditions is of the utmost importance because HG is a benign disease that is potentially reversible by improving glycemic control, whereas NAFLD can progress to cirrhosis. Therefore, HG should be suspected when liver dysfunction occurs in patients with poorly controlled T1 D. The aim of this article is to review the epidemiology, clinical characteristics, pathogenesis and histology of HG. | María Teresa Julián Núria Alonso Isabel Ojanguren Eduarda Pizarro Enric Ballestar Manel Puig-Domingo | 2015 | World Journal of Diabetes2015，6，2： | 4 |
| 3 | Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: correlation with cellular differentiation显示文摘 | Carlos Nicolau Violeta Catalá Ramón Vilana Rosa Gilabert Luis Bianchi Manel Solé Mario Pagés Concepció Brú | 2004 | European Radiology2004，，6： | 2 |
| 4 | Specific microbiota di- rect the differentiation of IL-17-produeing T-helper ceils in the mucosa of the small intestine显示文摘 | Ivanov II Frutosrde L Manel N | 2008 | Cell Host Microbe2008，4，4： | 1 |
| 5 | The differentiation of human Th-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt显示文摘 | Manel N Unutmaz D Littman DR | 2008 | Nature Immunol2008，9，6： | 1 |
| 6 | The differentiation of hu- man T(H)-17 ceils requires transforming growth factor-beta and induction of the nuclear receptor RORgammat显示文摘 | Manel N Unutmaz D Littman DR | 2008 | Nat Immunol2008，9，6： | 1 |
| 7 | The differentiation of human T(H)-17 cells requires transforming growth factor- beta and induction of the nuclear receptor RORgammat显示文摘 | Manel N Unutmaz D Littman DR | 2008 | Nat Immunol2008，9，6： | 1 |
| 8 | Specific microbiota direct Ihe differentiation of IL-17-producing T-helper cells in the mucosa of the small imestine显示文摘 | IVANOV I1 FRUTOS RDE L MANEL N | 2008 | Cell Host Micrebe2008，4，4： | 1 |
| 9 | Induction of intestinal Thl7 cells by segmented filamentous bacteria显示文摘 | Ivanov II Atarashi K Manel N | 2009 | Cell2009，139，3： | 1 |
| 10 | The EXAMINATION (Everolimus-Eluting Stents Versus Bare-Metal Stents in ST-Segment Elevation Myocardial Infarction) Trial显示文摘 | Manel Sabaté Salvatore Brugaletta Angel Cequier Andrés I?iguez Antonio Serra Rosana Hernádez-Antolín Vicente Mainar Marco Valgimigli Maurizio Tespili Pieter den Heijer Armando Bethencourt Nicolás Vázquez Bianca Backx Patrick W. Serruys | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 11 | The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor ROR gamma 显示文摘 | Manel N Unutmaz D Littman DR | 2008 | Nat Immunol2008，9，6： | 1 |
| 12 | Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: correlation with cellular differentiation显示文摘 | Carlos Nicolau Violeta Catalá Ramón Vilana Rosa Gilabert Luis Bianchi Manel Solé Mario Pagés Concepció Brú | 2004 | European Radiology2004，，6： | 1 |
| 13 | A cryptic sensor for HIV-1activates antiviral innate immunity in dendritic cells显示文摘 | Manel N Hogstad B Wang Y | 2010 | Nature2010，467，7312： | 1 |
| 14 | The differentiation of human T (H)-17 cells requireds transforming growth factor-beta and induction of the nuclear receptor RORgammat显示文摘 | Manel N Unutmaz D Littman DR | 2008 | Nat Immunol2008，9，6： | 1 |
| 15 | The differentiation of human Th-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt显示文摘 | Manel N Unutmaz D Littman DR | 2008 | Nat Immunol2008，9，4： | 1 |
| 16 | The differentiation of human Thl7 cells requires transforming growth factor - 13and induction of the nuclear receptor ROR3γt 显示文摘 | Manel N Unutmaz D Littman DR | 2008 | Nature Immunol2008，9，6： | 1 |
| 17 | The differentiation of human T (H)-17 ceils requires transforming growth factor-beta and induction of the nuclear receptor RORgammat 显示文摘 | Manel N Unutmaz D Littman DR | 2008 | Nat Immunol2008，9，6： | 1 |
| 18 | Induction of intestinal Thl7 cells by segmented filamentous bacteria 显示文摘 | IVANOV I I ATARASHI K MANEL N | 2009 | Cell2009，139，48： | 1 |
| 19 | The differentiation of human TH - 17 cells requires transforming growth factor - 13 and induction of the nuclear receptor ROR'yT 显示文摘 | Manel N Unutmaz D Littman DR | 2008 | Nat Immunol2008，9，6： | 1 |
| 20 | Tne differentiation of human TH17 cells requires transforming growth factorband induction of the nuclear receptor RORγt显示文摘 | Manel N Unutma D Littman DR | 2008 | Nat Immunol2008，9，6： | 1 |
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