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| 1 | Radiological response and inflammation scores predict tumour recurrence in patients treated with transarterial chemoembolization before liver transplantation显示文摘AIM To investigate the prognostic value of the radiological response after transarterial chemoembolization(TACE)and inflammatory markers in patients affected by hepatocellular carcinoma(HCC)awaiting liver transplantation(LT).METHODS We retrospectively evaluated the preoperative pre dictors of HCC recurrence in 70 patients treated with conventional(n=16)or doxorubicin-eluting bead TACE(n=54)before LT.The patient and tumour characteristics,including the static and dynamic alpha-fetoprotein,neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio( LR)measurements,were recorded.Treatment response was classified according to the modified Response Evaluation Criteria in Solid Tumours(m RECIST)and the European Association for the Study of the Liver(EASL)criteria as complete response(CR),partial response( R),stable disease o progressive disease.After examination of the explanted livers,histological necrosis was classified as complete(100%of the cumulative tumour area),partia(50%-99%)or minimal(<50%)and was correlated with the preoperative radiological findings.RESULTS According to the pre-TACE radiological evaluation,22/70(31.4%)and 12/70(17.1%)patients were beyond Milan and University of San Francisco(UCSF)criteria,respectively.After TACE procedures,the objective response(CR+ R)rates were 71.4%and 70.0%according to m RECIST and EASL criteria,respectively.The agreement between the two guidelines in defining the radiological response was rated as very good both for the overall and target lesion response(weighted k-value:0.98 and 0.93,respectively).Complete and partial histological necrosis were achieved in 14/70(20.0%)and 28/70(40.0%)patients,respectively.Using histopathology as the reference standard,m RECIST criteria correctly classified necrosis in 72.9%(51/70)of patients and EASL criteria in 68.6%(48/70)of cases.The m RECIST non-response to TACE[Exp(b)=9.2, =0.012],exceeding UCSF criteria before TACE[Exp(b)=4.7, =0.033]and a preoperative LR>150[Exp(b)=5.9, =0.046]were independent predictors of tumour recurrence.CONCLUSION The radiological response and inflammatory markers are predictive of tumour recurrence and allow the proper selection of TACE-treated candidates for LT. | Daniele Nicolini Andrea Agostini Roberto Montalti Federico Mocchegiani Cinzia Mincarelli Alessandra Mandolesi Nicola L Robertson Roberto Candelari Andrea Giovagnoni Marco Vivarelli | 2017 | World Journal of Gastroenterology2017，23，20： | 4 |
| 2 | Correlation between coronary ar-tery disease severity,left ventricular mass index and ca-rotid intima media thickness,assessed by radio-frequen-cy显示文摘 | Ciccone M M Scicchitano P Zito A Agati L GesualdoM Mandolesi S | 2011 | Cardiovasc Ultrasound2011，9，： | 1 |
| 3 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat显示文摘 | Leggio MG Mandolesi L Federico F | 2005 | Behav Brain Res2005，163，1： | 1 |
| 4 | Environmental enrichment mitigates the effects of basal forebrain lesions on cognitive flexibility显示文摘 | De Bartolo P Leggio MG Mandolesi L | 2008 | Neuroscience2008，154，2： | 1 |
| 5 | Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion显示文摘 | Mandolesi L De Bartolo P Foti F | 2008 | J Alzheimers Dis2008，15，1： | 1 |
| 6 | The Planck satellite显示文摘 | MANDOLESI M VILLA F VALENZIANO L | 2002 | Advances in Space Research2002，30，： | 1 |
| 7 | Watch how to do it New advances in learning by observation显示文摘 | PetrosiniLi Graziano A Mandolesi L | 2003 | Brain Research Re views2003，42，3： | 1 |
| 8 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat显示文摘 | Leggio M G Mandolesi L Federico F | | 0，，： | 1 |
| 9 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat显示文摘 | Leggio M G Mandolesi L Federico F | 2005 | Behav Brain Res2005，163，1： | 1 |
| 10 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat显示文摘 | Leggio MG Mandolesi L Federico F | | Behavioural Brain Research0，，： | 1 |
| 11 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat显示文摘 | Leggio MG Mandolesi L Federico F | 2005 | Behav Brain Res2005，163，1： | 1 |
| 12 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat 显示文摘 | Leggio MG Mandolesi L Federico F | 2005 | Behav Brain Res2005，163，1： | 1 |
| 13 | Environ- mental enrichment pr6vides a cognitive reserve to be spent in the case of brain lesion 显示文摘 | Mandolesi L De Bartolo P Foti F | 2008 | J Alzheimers Dis2008，15，： | 1 |
| 14 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat 显示文摘 | Leggio MG Mandolesi L Federico F | 2005 | Behav Brain Res2005，163，1： | 1 |
| 15 | Correlation of insulin - like growth factor 1 ( IGF-1 ) expression and clinical outcome in K- RAS wild-type colorectal cancer patients treated with cetuximabirinotecan显示文摘 | Scartozzi M Bearzi l Mandolesi A | 2009 | J Clin Oncol2009，，： | 1 |
| 16 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat显示文摘 | Leggio MG Mandolesi L Federico F | | 0，，1： | 1 |
| 17 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat显示文摘 | Leggio MG Mandolesi L Federico F | 2005 | Behav Brain Res2005，163，： | 1 |
| 18 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat显示文摘 | Leggio MG Mandolesi L Federico F | 2005 | Behav Brain Res2005，163，1： | 1 |
| 19 | Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion显示文摘 | Mandolesi L De Bartolo P Foti F | 2008 | Alzheimers Dis2008，15，1： | 1 |
| 20 | Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat 显示文摘 | Leggio MG Mandolesi L Federico F | 2005 | Behav Brain Res2005，163，1： | 1 |
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