|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase显示文摘AIM:To investigate lipopolysaccharide(LPS) related signal transduction in interstitial cells of Cajal(ICCs) from mouse small intestine.METHODS:For this study,primary culture of ICCs was prepared from the small intestine of the mouse.LPS was treated to the cells prior to measurement of the membrane currents by using whole-cell patch clamp technique.Immunocytochemistry was used to examine the expression of the proteins in ICCs.RESULTS:LPS suppressed the pacemaker currents of ICCs and this could be blocked by AH6809,a prostaglandin E2-EP2 receptor antagonist or NG-Nitro-Larginine Methyl Ester,an inhibitor of nitric oxide(NO) synthase.Toll-like receptor 4,inducible NO synthase or cyclooxygenase-2 immunoreactivity by specific antibodies was detected on ICCs.Catalase(antioxidant agent) had no action on LPS-induced action in ICCs.LPS actions were blocked by nuclear factor kB(NF-kB) inhibitor,actinomycin D(a gene transcription inhibitor),PD 98059(a p42/44 mitogen-activated protein kinases inhibitor) or SB 203580 [a p38 mitogen-activated protein kinases(MAPK) inhibitor].SB 203580 also blocked the prostaglandin E2-induced action on pacemaker currents in ICCs but not NO.CONCLUSION:LPS inhibit the pacemaker currents in ICCs via prostaglandin E2-and NO-dependent mechanism through toll-like receptor 4 and suggest that MAPK and NF-kB are implicated in these actions. | Dong Chuan Zuo Seok Choi Pawan Kumar Shahi Man Yoo Kim Chan Guk Park Young Dae Kim Jun Lee In Yeoup Chang Insuk So Jae Yeoul Jun | 2013 | World Journal of Gastroenterology2013，19，8： | 9 |
| 2 | Improvement of diabetes and hypertension after gastrectomy: A nationwide cohort study显示文摘AIM: To evaluate the effect of gastrectomy on diabetes mellitus(DM) and hypertension(HTN) in non-obese gastric cancer patients. METHODS: A total of 100000 patients, diagnosed with either type 2 DM or HTN, were randomly selected from the 2004 Korean National Health Insurance System claims. Among them, 360 diabetes and 351 hypertensive patients with gastric cancer who had been regularly treated without chemotherapy from January 2005 to December 2010 were selected. They were divided into three groups according to their treatment methods: total gastrectomy(TG), subtotal gastrectomy(STG) and endoscopic resection(ER). RESULTS: The drug discontinuation rate of antidiabetic and anti-hypertensive agents after gastric cancer treatment was 9.7% and 11.1% respectively. DM appeared to be improved more frequently(22.8%) and earlier(mean ± SE 28.6 ± 1.8 mo) in TG group than in the two other groups [improved in 9.5% of ER group(37.4 ± 1.1 mo) and 6.4% of STG group(47.0 ± 0.8 mo)]. The proportion of patients treated with multiple drugs decreased more notably in TG group compared to others(P = 0.001 in DM, and P = 0.035 in HTN). In TG group, adjusted hazard ratio for theimprovement of DM was 2.87(95%CI: 1.15-7.17) in a multi-variate analysis and better control of DM was observed with survival analysis(P < 0.001).CONCLUSION: TG was found to decrease the need for anti-diabetic medications which can be reflective of improved glycemic control, to a greater extent than either ER or STG in non-obese diabetic patients. | Eun Kyung Lee So Young Kim You Jin Lee Mi Hyang Kwak Hak Jin Kim Il Ju Choi Soo-Jeong Cho Young Woo Kim Jong Yeul Lee Chan Gyoo Kim Hong Man Yoon Bang Wool Eom Sun-Young Kong Min Kyong Yoo Jong Hyock Park Keun Won Ryu | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 3 | Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: The Korean Sarcopenic Obesity Study (KSOS)显示文摘 | Tae Nyun Kim Man Sik Park Kang Il Lim Sae Jeong Yang Hye Jin Yoo Hyun Joo Kang Wook Song Ji A. Seo Sin Gon Kim Nan Hee Kim Sei Hyun Baik Dong Seop Choi Kyung Mook Choi | 2011 | Diabetes Research and Clinical Practice2011，，2： | 2 |
| 4 | HBV DNA and HBsAg Levels as Risk Predictors of Early and Late Recurrence after Curative Resection of HBV-related Hepatocellular Carcinoma显示文摘 | Won Sohn Yong-Han Paik Jong Man Kim Choon Hyuk Kwon Jae Won Joh Ju Yeon Cho Geum-Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Annals of Surgical Oncology2014，，7： | 2 |
| 5 | Inhibition of pacemaker currents by nitric oxide via activation of ATP-sensitive K+ channels in cultured interstitial cells of Cajal from the mouse small intestine显示文摘 | Chan Guk Park Young Dae Kim Man Yoo Kim Jun Soo Kim Seok Choi Cheol Ho Yeum Shankar Prasad Parajuli Jong Seong Park Han Seong Jeong Insuk So Ki Whan Kim Jae Yeoul Jun | 2007 | Naunyn - Schmiedeberg’s Archives of Pharmacology2007，，3： | 1 |
| 6 | Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses显示文摘 | Yanyan Yang Seung Cheol Kim Tao Yu Young-Su Yi Man Hee Rhee Gi-Ho Sung Byong Chul Yoo Jae Youl Cho Pham My-Chan Dang | 2014 | Mediators of Inflammation2014，，： | 1 |
| 7 | Serum Adipocyte Fatty Acid-Binding Protein Is Associated Independently with Vascular Inflammation: Analysis with 18F-Fluorodeoxyglucose Positron Emission Tomography显示文摘 | Hye Jin Yoo Sungeun Kim Man Sik Park Hae Yoon Choi Sae Jeong Yang Ji A. Seo Sin Gon Kim Nan Hee Kim Sei Hyun Baik Dong Seop Choi Kyung Mook Choi | 2011 | Clinical Endocrinology and Metabolism2011，，3： | 1 |
| 8 | Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea显示文摘 | Ja Young Lee Hak Yang Kim Kyung Ho Kim Seong Man Kim Myoung Kuk Jang Joon Yong Park Jin Heon Lee Jin-Ho Kim Jae Young Yoo | 2004 | Cancer Letters2004，，2： | 1 |
| 9 | Steatosis Among Living Liver Donors Without Evidence of Fatty Liver on Ultrasonography: Potential Implications for Preoperative Liver Biopsy显示文摘 | Joon Seong Ahn Dong Hyun Sinn Geum-Youn Gwak Jong Man Kim Choon Hyuck Kwon Jae Won Joh Yong-Han Paik Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2013 | Transplantation Journal2013，，11： | 1 |
| 10 | Unmethylation of the CHRNB4 gene is an unfavorable prognostic factor in non-small cell lung cancer显示文摘 | Seung Soo Yoo Su Man Lee Sook Kyung Do Won Kee Lee Dong Sun Kim Jae Yong Park | 2014 | Lung Cancer2014，，1： | 1 |
| 11 | Effects of prostaglandin F_(2α) on small intestinal interstitial cells of Cajal显示文摘AIM:To explore the role of prostaglandin F2α(PGF2α) on pacemaker activity in interstitial cells of Cajal(ICC)from mouse small intestine. METHODS:In this study,effects of PGF2αin the cultured ICC cells were investigated with patch clamp technology combined with Ca 2+ image analysis. RESULTS:Externally applied PGF2α(10μmol/L)produced membrane depolarization in current-clamp mode and increased tonic inward pacemaker currents in voltage-clamp mode.The application of flufenamic acid(a non-selective cation channel inhibitor)or niflumic acid(aCl channel inhibitor)abolished the generation of pacemaker currents but only flufenamic acid inhibited the PGF2α-induced tonic inward currents.In addition,the tonic inward currents induced by PGF2αwere not inhibited by intracellular application of 5’-[-thio]diphosphate trilithium salt.Pretreatment with Ca 2+ free solution, U-73122,an active phospholipase C inhibitor,and thapsigargin,a Ca 2+ -ATPase inhibitor in endoplasmic reticulum,abolished the generation of pacemaker currents and suppressed the PGF2α-induced tonic inward currents.However,chelerythrine or calphostin C,protein kinase C inhibitors,did not block the PGF2α-induced effects on pacemaker currents.When recording intracellular Ca 2+ ([Ca 2+ ]i)concentration using fluo-3/AM,PGF2α broadly increased the spontaneous[Ca 2+ ]i oscillations. CONCLUSION:These results suggest that PGF2αcan modulate pacemaker activity of ICC by acting non-selective action channels through phospholipase C-dependent pathway via[Ca2+]i | Chan Guk Park Young Dae Kim Man Yoo Kim Jae Woong Koh Jae Yeoul Jun Cheol Ho Yeum Insuk So Seok Choi | 2011 | World Journal of Gastroenterology2011，17，9： | 1 |
| 12 | 8-(Tosylamino)quinoline inhibits macrophage-mediated inflammation by suppressing NF-KB signaling显示文摘 | Yongwoo JUNG Se Eun BYEON Dae Sung YOO Yong Gyu LEE Tao YU Yanyan YANG Ji Hye KIM Eunji KIM Deok JEONG Man Hee RHEE Eui Su CHOUNG Sungyoul HONG Jae Youl CliO | 2012 | Acta Pharmacologica Sinica2012，33，8： | 0 |
| 13 | Novel extended C-m models of flow stress for accurate mechanical and metallurgical calculations and comparison with traditional flow models显示文摘Here,we developed novel extended piecewise bilinear power law(C-m)models to describe flow stresses under broad ranges of strain,strain rate,and temperature for mechanical and metallurgical calculations during metal forming at elevated temperatures.The traditional C-m model is improved upon by formulating the material parameters C and m,defined at sample strains and temperatures as functions of the strain rate.The coefficients are described as a linear combination of the basis functions defined in piecewise patches of the sample strain and temperature domain.A comparison with traditional closed-form function flow models revealed that our approach using the extended piecewise bilinear C-m model is superior in terms of accuracy,ease of use,and adaptability;additionally,the extended C-m model was applicable to numerical analysis of mechanical,metallurgical,and microstructural problems.Moreover,metallurgy-related values can be calculated directly from the flow stress information.Although the proposed model was developed for materials at elevated temperatures,it can be applied over a broad temperature range. | Man Soo Joun Mohd Kaswandee Razali Jae Dong Yoo Min Cheol Kim Jeong Muk Choi | 2022 | Journal of Magnesium and Alloys2022，10，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员