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| 1 | Comparison of efficacy of folic acid and silymarin in the management of antiepileptic drug induced liver injury:a randomized clinical trial显示文摘BACKGROUND: Liver injury associated with antiepileptic drugs accounts for a large proportion of drug-induced liver injuries(DILI) in children. Although withdrawal of the causative agent is the only proved treatment for DILI, in some clinical situations it is not possible. Recent studies have reported promising results of using hepatoprotective drugs with antioxidant actions for the management of DILI. This study aimed to evaluate the efficacy of folic acid versus silymarin treatment in relation to decreasing liver enzymes in patients with DILI due to antiepileptic therapy.METHODS: This randomized, open-label, clinical trial evaluated 55 children with epilepsy who were on antiepileptic treatment and experienced DILI. The children were randomized to receive either silymarin(5 mg/kg per day) or folic acid(1 mg per day) for one month and were followed up for three months.RESULTS: Liver enzymes significantly decreased in both groups. The decrease trend in alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were stronger in the folic acid group compared to silymarin group(P=0.04 and P=0.007, respectively). At the end of the study patients in the folic acid group had significantly lower ALT(P=0.04), AST(P=0.02), and gamma-glutamyl transferase(GGT)(P<0.001) levels and also higher percentage of normal ALT(30.7% vs 3.4%, P=0.009) and AST(42.3% vs 0%, P<0.001), and GGT(23.1% vs 0%, P=0.008) values compared to the patients in the silymarin group. No rebound elevations in ALT, AST and GGT levels or adverse reactions were noted in neither of the study groups.CONCLUSION: Although both treatments were safe and effective in decreasing liver enzymes, folic acid seems to be superior to silymarin in the management of DILI. | Masoumeh Asgarshirazi Mamak Shariat Mahdi Sheikh | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 2 |
| 2 | Electroactive mesoporous ynria stabilized zirconia containing platinmn or nickel oxide nanoclusters: a new class of solid oxide tuel cell electrode materials 显示文摘 | Mamak M Coombs N Ozin G A | 2001 | Ad- vanced Functional Materials2001，11，1： | 1 |
| 3 | The synthesis, characterization and electrochemical behavior of the layered LiNi04Mn04Co0zO2 compound 显示文摘 | NGALA J K CHERNOVA N A MA M MAMAK M ZAVALIJ P Y WHITTINGHAM M S | 2004 | J Mater Chem2004，14，： | 1 |
| 4 | Quality of life assessment with the use of the SF-36 in patients with nasal polyposis: correlations with clinical and laboratory findings 显示文摘 | Derekoylu L Canakeioglu S Mamak A | 2003 | Kulak Bunm Bogaz Ihtis Derg2003，11，3： | 1 |
| 5 | Novel approaches in NIR curing technology显示文摘 | Knischka R Lehmann U Stadler U Mamak M Benkhoff J | 2009 | Pro-gress in Organic Coatings2009，64，23： | 1 |
| 6 | A study of prognostic factors in sudden heating loss 显示文摘 | Mamak A Yilmaz S Cansiz H | 2005 | Ear Nose Throat J2005，84，10： | 1 |
| 7 | Thermally Stable Two-Dimensional Hexagonal Mesoporous Nanocrystalline Anatase, Meso-nc-TiO2:Bulk and Crack-Free Thin Film Morphologies 显示文摘 | Choi S Y Mamak M | 2004 | Advanced Functional Materials2004，14，4： | 1 |
| 8 | Environ- mental carbon monoxide related to pregnancy hypertension 显示文摘 | Mohsen Vigeh Masoud Yunesian Mamak Shariat | 2011 | Women Amp Health2011，51，8： | 1 |
| 9 | Mesoporous Bragg stack color tunable sensors显示文摘 | Choi S Y Mamak M von Freymann G | 2006 | Nano letters2006，6，11： | 1 |
| 10 | Thermally stable two-dimensional hexagonal mesoporous nanocrystal- line anatase, meso-nc-TiO2 : bulk and crack-free thin film morphologies显示文摘 | Sung Yeun Choi Marc Mamak Neil Coombs | 2004 | Adv Funet Mater2004，14，4： | 1 |
| 11 | Electrochromic performance of viologen-medified periodic mesoporous nanocrystalline anatase electrodes显示文摘 | Choi S Y Mamak M Coombs N | 2004 | Nano letters2004，4，7： | 1 |
| 12 | 查看详情显示文摘 | Halla J.D Mamak M Williams D.E Ozin G.A | | 0，，2： | 1 |
| 13 | The METFORS Fitness Questionnaire(MFQ): A self-report measure for screening competency to stand trial 显示文摘 | Nussbaum D Mamak M Tremblay H | 1998 | American Journal of Forensic Psychology1998，16，3： | 1 |
| 14 | Mesoporous Yttria-Zirconia and Metal-Yttria-Zirconia Solid Solutions for Fuel Cells 显示文摘 | Mamak M Coombs N Ozin G | 2000 | Adv Mater2000，12，3： | 1 |
| 15 | Thermally stable two- dimensional hexagonal mesoporous nanocrystalline anatase, meso-nc-TiO2 :Bulk and crack-free thin film morphoiogies显示文摘 | Choi S Y Mamak M Coombs N | 2004 | Adv Funct Mater2004，15，2： | 1 |
| 16 | A study of prognostic factors in sudden hearing loss 显示文摘 | MAMAK A YILMAZ S CANSIZ H | 2005 | Ear Nose Throat2005，84，： | 1 |
| 17 | A study of prognostic factors in sudden hearing loss显示文摘 | Mamak A Yilmaz S Cansiz H | 2005 | Ear Nose Throat2005，84，10： | 1 |
| 18 | Content pre- sentation personalisation and media adaptation in tourism websites using fuzzy delphi method and fuzzy cogni- tive Maps显示文摘 | Kardaras D K Karakostas B Mamakou X J | 2013 | Expert Systems with Applications2013，40，6： | 1 |
| 19 | Electrochromic performance of viologen-modified periodic mesoporous nanocrystalline anatase electrodes显示文摘 | Choi S Y Mamak M Coombs N Ozin G A | 2004 | Nano letters2004，4，7： | 1 |
| 20 | Thermally stable two-dimensional hexagonal mesoporous nanocrystalline anatase, meso-nc-TiOz: Bulk and crack-free thin film morphologies 显示文摘 | CHOI S MAMAK M COOMBS N OZIN G | 2004 | Adv Funct Mater2004，14，： | 1 |
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