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| 1 | 3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances显示文摘3D printing,an additive manufacturing based technology for precise 3D construction,is currently widely employed to enhance applicability and function of cell laden scaffolds.Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering.Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting.Other important factors include but are not limited to printing fidelity,stability,crosslinking time,biocompatibility,cell encapsulation and proliferation,shear-thinning properties,and mechanical properties such as mechanical strength and elasticity.In this review,we recite recent promising advances in bioink development as well as bioprinting methods.Also,an effort has been made to include studies with diverse types of crosslinking methods such as photo,chemical and ultraviolet(UV).We also propose the challenges and future outlook of 3D bioprinting application in medical sciences and discuss the high performance bioinks. | Soroosh Derakhshanfar Rene Mbeleck Kaige Xu Xingying Zhang Wen Zhong Malcolm Xing | 2018 | Bioactive Materials2018，3，2： | 21 |
| 2 | Viscosity and degradation controlled injectable hydrogel for esophageal endoscopic submucosal dissection显示文摘Endoscopic submucosal dissection(ESD)is a common procedure to treat early and precancerous gastrointestinal lesions.Via submucosal injection,a liquid cushion is created to lift and separate the lesion and malignant part from the muscular layer where the formed indispensable space is convenient for endoscopic incision.Saline is a most common submucosal injection liquid,but the formed liquid pad lasts only a short time,and thus repeated injections increase the potential risk of adverse events.Hydrogels with high osmotic pressure and high viscosity are used as an alternate;however,with some drawbacks such as tissue damage,excessive injection resistance,and high cost.Here,we reported a nature derived hydrogel of gelatin-oxidized alginate(G-OALG).Based on the rheological analysis and compare to commercial endoscopic mucosal resection(EMR)solution(0.25%hyaluronic acid,HA),a designed G-OALG hydrogel of desired concentration and composition showed higher performances in controllable gelation and injectability,higher viscosity and more stable structures.The G-OALG gel also showed lower propulsion resistance than 0.25%HA in the injection force assessment under standard endoscopic instruments,which eased the surgical operation.In addition,the G-OALG hydrogel showed good in vivo degradability biocompatibility.By comparing the results acquired via ESD to normal saline,the G-OALG shows great histocompatibility and excellent endoscopic injectability,and enables create a longer-lasting submucosal cushion.All the features have been confirmed in the living both pig and rat models.The G-OALG could be a promising submucosal injection agent for esophageal ESD. | Chaoqiang Fan Kaige Xu Yu Huang Shuang Liu Tongchuan Wang Wei Wang Weichao Hu Lu Liu Malcolm Xing Shiming Yang | 2021 | Bioactive Materials2021，6，4： | 3 |
| 3 | Textiles and human skin, microclimate, cutaneous reactions: an overview 显示文摘 | WEN Zhong XING Malcolm M Q PAN Ning | 2006 | Cutaneous and Ocular Toxicology2006，，25： | 1 |
| 4 | Hydrophobic aerogel-modified hemostatic gauze with thermal management performance显示文摘Current hemostatic agents or dressings are not efficient under extremely hot and cold environments due to deterioration of active ingredients,water evaporation and ice crystal growth.To address these challenges,we engineered a biocompatible hemostatic system with thermoregulatory properties for harsh conditions by combining the asymmetric wetting nano-silica aerogel coated-gauze(AWNSA@G)with a layer-by-layer(LBL)structure.Our AWNSA@G was a dressing with a tunable wettability prepared by spraying the hydrophobic nano-silica aerogel onto the gauze from different distances.The hemostatic time and blood loss of the AWNSA@G were 5.1 and 6.9 times lower than normal gauze in rat’s injured femoral artery model.Moreover,the modified gauze was torn off after hemostasis without rebleeding,approximately 23.8 times of peak peeling force lower than normal gauze.For the LBL structure,consisting of the nano-silica aerogel layer and a n-octadecane phase change material layer,in both hot(70℃)and cold(-27℃)environments,exhibited dual-functional thermal management and maintained a stable internal temperature.We further verified our composite presented superior blood coagulation effect in extreme environments due to the LBL structure,the pro-coagulant properties of nano-silica aerogel and unidirectional fluid pumping of AWNSA@G.Our work,therefore,shows great hemostasis potential under normal and extreme temperature environments. | Xiaoli Jia Chao Hua Fengbo Yang Xiaoxiao Li Peng Zhao Feifan Zhou Yichi Lu Hao Liang Malcolm Xing Guozhong Lyu | 2023 | Bioactive Materials2023，，8： | 1 |
| 5 | Bridging wounds:tissue adhesives’essential mechanisms,synthesis and characterization,bioinspired adhesives and future perspectives显示文摘Bioadhesives act as a bridge in wound closure by forming an effective interface to protect against liquid and gas leakage and aid the stoppage of bleeding.To their credit,tissue adhesives have made an indelible impact on almost all wound-related surgeries.Their unique properties include minimal damage to tissues,low chance of infection,ease of use and short wound-closure time.In contrast,classic closures,like suturing and stapling,exhibit potential additional complications with long operation times and undesirable inflammatory responses.Although tremendous progress has been made in the development of tissue adhesives,they are not yet ideal.Therefore,highlighting and summarizing existing adhesive designs and synthesis,and comparing the different products will contribute to future development.This review first provides a summary of current commercial traditional tissue adhesives.Then,based on adhesion interaction mechanisms,the tissue adhesives are categorized into three main types:adhesive patches that bind molecularly with tissue,tissuestitching adhesives based on pre-polymer or precursor solutions,and bioinspired or biomimetic tissue adhesives.Their specific adhesion mechanisms,properties and related applications are discussed.The adhesion mechanisms of commercial traditional adhesives as well as their limitations and shortcomings are also reviewed.Finally,we also discuss the future perspectives of tissue adhesives. | Kaige Xu Xiaozhuo Wu Xingying Zhang Malcolm Xing | 2022 | Burns & Trauma2022，10，1： | 0 |
| 6 | 对氨基苯甲酸掺杂的微槽结构碳纤维用于改善PLA-PEG的强度及生物相容性(英文)显示文摘本文利用一种叶酸代谢产物,对氨基苯甲酸(PABA),来改性碳纤维(CFs),通过在其表面形成微槽结构以达到改善其亲水性的目的.采用溶液浇注/粒子沥滤法制备了CFs/PLA-PEG复合生物支架.研究发现,引入小的PABA疏水分子可以在CFs和聚乳酸-聚乙二醇(PLA-PEG)基体之间形成良性结合界面.CFs/PLA-PEG生物支架的抗压强度从3.98MPa提高到5.48MPa.由于PABA的改性,低毒性的CFs/PLA-PEG复合材料显著加速了预成骨细胞的粘附,对细胞增殖没有明显影响.通过比较支架上的L929细胞和MC_3T_3细胞的生物相容性,可以认为PABA-CFs不仅克服了PLA-PEG强度差的缺陷,而且可以促进细胞的生长,证明了PABA-CFs增强PLA-PEG生物复合材料可作为一种潜在的组织工程支架材料. | 史燕妮 李敏 王宁 Malcolm xing 吴琪琳 | 2016 | Science China Materials2016，59，11： | 0 |
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