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| 1 | Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes显示文摘AIM: To investigate the influence of proton pump inhibitors(PPIs) exposure on the diagnosis of Helicobacter pylori(H. pylori) gastritis and intestinal metaplasia.METHODS: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma. Three hundred patients diagnosed with gastritis between January 2008 and April 2010 were included in our study. The computerized medical database of these patients was reviewed retrospectively in order to assess whether the type of gastritis diagnosed(H. pylori vs non-H. pylori gastritis) is influenced by PPI exposure. H. pylori density was graded as low, if corresponding to mild density following the Updated Sydney System, or high, if corresponding to moderate or severe densities in the Updated Sydney System.RESULTS: Patients were equally distributed between males and females with a median age at the time of diagnosis of 50 years old(range: 20-87). The histological types of gastritis were classified as H. pylori gastritis(n = 156, 52%) and non-H. pylori gastritis(n = 144, 48%). All patients with non-H. pylori gastritis had inactive chronic gastritis. Patients with no previous PPI exposure were more likely to be diagnosed with H. pylori gastritis than those with previous PPI exposure(71% vs 34.2%, P < 0.001). Intestinal metaplasiawas more likely to be detected in the latter patients(1.4% vs 6.5%, P = 0.023). Multivariate analysis has also demonstrated that in the presence of previous PPI exposure(OR = 0.217, 95%CI: 0.123-0.385), GERD(OR = 0.317, 95%CI: 0.132-0.763, P = 0.01), alcohol intake(OR = 0.396, 95%CI: 0.195-0.804, P = 0.01), the detection of H. pylori was less likely. Chronic use of PPIs may mask H. pylori infections promoting the diagnosis of non-H. pylori gastritis and leads to a significant drop in H. pylori densities and to an increased risk of intestinal metaplasia.CONCLUSION: The use of PPIs masks H. pylori infection, promotes the diagnosis of non-H. pylori inactive chronic gastritis diagnosis, and increases the incidence of intestinal metaplasia. | Soumana C Nasser Mahmoud Slim Jeanette G Nassif Selim M Nasser | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 2 | Enzymatic hydrolysis of casein: effect of degree of hydrolysis on antigenicity and physical properties 显示文摘 | MAHMOUD M MALONE W CORDLE C | 1992 | Joumai of Food Science1992，57，5： | 1 |
| 3 | A new catalytically active colloidal platinum nanocatalyst: the multi- armed nanostar single crystal显示文摘 | MAHMOUD M A TABOR C E EL-SAYED M A | 2008 | Journal of the American Chemi- cal Society2008，130，14： | 1 |
| 4 | Response of the Posterior Corneal Surface to Laser in Situ Keratomileusis for Myopia显示文摘 | Twa M D Roberts C Mahmoud A M | 2005 | Journal of Cataract & Refractive Surgery2005，31，1： | 1 |
| 5 | Enzymatic hydrolysis of casein: Effect of degree of hydrolysis on antigenicity and physical properties 显示文摘 | Mahmoud M Malone W Cordle C | 1992 | Journal of Food Science1992，57，5： | 1 |
| 6 | Investigation of Mn-ferrite films produced by pulsed laser deposition显示文摘 | MAHMOUD M H WILLIAMS C M CAI J | 2003 | Journal of Magnetism and Magnetic Materials2003，261，3： | 1 |
| 7 | Observer-based positive real control of uncertain linear systems显示文摘 | Mahmoud M S Soh Y C Xie L H | 1999 | Automatica1999，35，4： | 1 |
| 8 | Multiobjective Output-Feedback Control Via LMI Optimization显示文摘 | Carsten S Pascal G Mahmoud C | 1997 | IEEE Trans on Automatic Control1997，42，7： | 1 |
| 9 | Enzymatic hydrolysis of casein, effect of degree of hydrolysis on antigenicity and physical properties显示文摘 | MAHMOUD M I MALONE W COROLLE C T | 1992 | J Food Sd1992，57，5： | 1 |
| 10 | Design with Pole Placement Constrains:an LMI Approach显示文摘 | Mahmoud C Pascal G | 1996 | IEEE Trans on Automatic Control1996，41，3： | 1 |
| 11 | Observer-based positive real control for uncertain linear systems显示文摘 | Mahmoud M S Soh Y C Xie L H | 1995 | Automatica1995，35，4： | 1 |
| 12 | Pharmacological characterization of the chemokine receptor, CCR5显示文摘 | Mueller A Mahmoud N G Goedecke M C Mckeating J A Strange P G | 2002 | Br J Pharmacol2002，135，： | 1 |
| 13 | Enzymatic hydrolysis of casein:effect of degree of hydrolysis on antigenicity and physical properties显示文摘 | Mahmoud M L Malone W I Cordle C T | 1992 | J Food Science1992，57，5： | 1 |
| 14 | Current methods of non-invasive ventilator support for neonates显示文摘 | MAHMOUD R A ROEHR C C SCHMALISCH G | 2011 | Paediatric Respiratory Reviews2011，12，： | 1 |
| 15 | Enzymatic hydrolysis of casein: effect of degree of hydrolysis on antigenicity and physical properties 显示文摘 | MAHMOUD M I MALONE W T CORDLE C T | 1992 | J Food Sci1992，57，： | 1 |
| 16 | Robust kalman filtering for discrete state-delay systems显示文摘 | Mahmoud M S Xie L Soh Y C | 2000 | IEE Proc Control Theory Appication2000，147，6： | 1 |
| 17 | Screening of forme fruste keratoconus with the ocular response analyzer显示文摘 | Schweitzer C Roberts C J Mahmoud AM | 2010 | Invest Ophthal- mol Vis Sci2010，51，5： | 1 |
| 18 | Response of the posterior corneal surface to laser in situ keratomileusis for myopia显示文摘 | Twa MD Roberts C Mahmoud AM | 2005 | J Cataract Refract surg2005，31，1： | 1 |
| 19 | Normal embryonic stages of the western painted turtle,Chrysemyspicta bellii显示文摘 | MAHMOUD I HESS C KLICKA J | 1973 | Journal of Morphology1973，141，： | 1 |
| 20 | Robust pole placement in LMI regions显示文摘 | Mahmoud C Pascal G Pierre A | 1999 | IEEE Transaction on Automatic Control1999，44，12： | 1 |
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