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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Predictors of poor outcome in gastrointestinal bleeding in emergency department显示文摘AIM: To determine the prognostic risk factors of gastrointestinal bleeding in emergency department cases.METHODS: The trial was a retrospective single-center study involving 600 patients over 18-years-old and carried out with approval by the Institutional Ethics Committee. Patient data included demographic characteristics, symptoms at admission, past medical history, vital signs, laboratory results, endoscopy and colonoscopy results, length of hospital stay, need of intensive care unit(ICU) admission, and mortality. Mortality rate was the principal endpoint of the study, while duration of hospital stay, required interventional treatment, and admission to the ICU were secondary endpoints.RESULTS: The mean age of patients was 61.92-yearsold. Among the 600 total patients, 363(60.5%) underwent upper gastrointestinal endoscopy and the most frequent diagnoses were duodenal ulcer(19.2%) and gastric ulcer(12.8%). One-hundred-and-fifteen(19.2%) patients required endoscopic treatment, 20(3.3%) required surgical treatment, and 5(0.8%) required angiographic embolization. The mean length of hospital stay was 5.21 ± 5.85 d. The mortality rate was 6.3%. The ICU admission rate was 5.3%. Patients with syncope, higher blood glucose levels, and coronary artery disease had significantly higher ICU admission rates(P = 0.029, P = 0.043, and P = 0.002, respectively). Patients with low thrombocyte levels, high creatinine, high international normalized ratio, and high serum transaminase levels had significantly longer hospital stay(P = 0.02, P = 0.001, P = 0.019, and P = 0.005, respectively). Patients who died had significantly higher serum blood urea nitrogen and creatinine levels(P = 0.016 and P = 0.038), and significantly lower mean blood pressure and oxygen saturation(P = 0.004 and P = 0.049). Malignancy and low Glasgow coma scale(GCS) were independent predictive factors of mortality.CONCLUSION: Prognostic factors for gastrointestinal bleeding in emergency room cases are malignancy, hypotension on admission, low GCS, and impaired kidney function. | Ender Kaya Mehmet Ali Karaca Deniz Aldemir M Mahir Ozmen | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Staging laparoscopy for gastric cancer, surgical laparoscopy显示文摘 | Ozmen M Mahir MD MS | 2003 | Endoscopy & Percu taneous Techniques2003，13，4： | 1 |
| 4 | A Simple Finite Element to Consider the Non-linear Influence of the Ballast on Vibrations of Railway Bridges 显示文摘 | BATTINI J M MAHIR U K | 2011 | Engineering Structures2011，33，9： | 1 |
| 5 | Fate of the patient with chronic leg ischaemia:a review article显示文摘 | Dormandy J Mahir M Ascady G | 1989 | J Cardiovasc Surg (Torino)1989，30，1： | 1 |
| 6 | A Simple Finite Element toConsider the Non-linear Influence of the Ballast on Vibra-tions of Railway Bridges显示文摘 | BATTINI J M MAHIR U K | 2011 | Engineering Structures2011，33，9： | 1 |
| 7 | A simple finite element toconsider the non-linear influence of the ballast on vi-brations of railway bridge显示文摘 | Battini J M Mahir U K | 2011 | Engineering Struc-tures2011，33，9： | 1 |
| 8 | Lymph nodes in gastric cancer显示文摘 | M Mahir Ozmen Fusun Ozmen Baris Zulfikaroglu | 2008 | J Surg Oncol2008，98，6： | 1 |
| 9 | A Simple Finite Element to Consider the Non-Linear Influence of the Ballast on Vi- brations of Railway Bridges 显示文摘 | Battini J M Mahir U K | 2011 | Engineering Struc- tures2011，33，9： | 1 |
| 10 | Solubility of chlorine in aqueous hydrochloric acid solutions 显示文摘 | Mahir Alkan Munir Oktay M Muhtar Koeakerime Mehmet Copur | 2005 | Journal of Hazardous Materials2005，9，： | 1 |
| 11 | A simple finite element to consider the non-linear influence of the ballast on vibrations of railway bridges显示文摘 | BATTINI J M MAHIR U K | 2011 | Engineering Structures2011，33，9： | 1 |
| 12 | Reconstruction of the anterior crueiate ligament using bone-patellar tender-bone graft with double biodegrdable femoral pin fixation显示文摘 | Mahir M Yucel O Huceyin O | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，5： | 1 |
| 13 | Fate of the patient with chronic leg ischaemia: A review article显示文摘 | Dormandy J Mahir M Ascady G | 1989 | J Cardiovasc Surg1989，30，1： | 1 |
| 14 | Comparison of seldinger and trocar techniques in the percutaneous treatment of hydatid cysts显示文摘AIM To comparatively evaluate Seldinger and Trocar techniques in the percutaneous treatment of hydatid disease. METHODS Trocar and Seldinger techniques were used for 49 and 56 cysts, respectively, among 106 hydatid cysts in 88 patients. The number of males and females were 22 and 66, respectively with a mean age of 44.9 years(range, 15-87). Follow-up studies included cyst diameter, cyst contents, and morphological changes inthe cyst wall, local recurrence, and secondary invasion, using ultrasound, computerized tomography and chest X-rays. RESULTS The positive criteria of healing were a decrease in cyst diameter, progressive solidification of the cyst contents, and disappearance of the cyst. Local recurrence was defined as an increase in the cyst diameter and contents, and appearance of daughter cysts in the primary cavity, while secondary dissemination was defined as the appearance of new cysts outside the treated cyst. Mean duration of follow-up was 19.23 mo(range, 18-26 mo). Follow-up results demonstrated that no significant differences were present between the Trocar and Seldinger techniques in the percentage of decrease in the cyst volume, rate of early complications, local recurrence and secondary dissemination(P = 0.384, 0.069, 0.215 and 0.533, respectively). CONCLUSION There are no differences between the Seldinger and Trocar techniques that gain entry to the cyst cavity in terms of the efficacy of the treatment and the rates of early and late complications. | Hilal Gülsüm Turan Mustafa Ozdemir Rusen Acu Fahrettin Kücükay Fatma Ayca Edis Ozdemir Baki Hekimoglu Utku Mahir Yildirim | 2017 | World Journal of Radiology2017，9，11： | 1 |
| 15 | Fate of the patient with chronic leg ischaemia显示文摘 | Dormandy J Mahir M Ascady G | 1989 | J Cardiovasc Surg1989，30，： | 1 |
| 16 | A simple finite element to consider the non-linear influence of the ballast on vibrations of railway bridges显示文摘 | BATTINI J M MAHIR U K | 2011 | Engineering Structures2011，33，9： | 1 |
| 17 | Reconstruction of the anterior crucate ligament using bone-patellar tenderbone graftwith double biodegradable femoral pin fixation显示文摘 | Mahir M Yucel O Huceyin O | | 0，，05： | 1 |
| 18 | 非角膜地形图引导PRK联合角膜胶原交联术治疗圆锥角膜(英文)显示文摘目的:评估非角膜地形图引导圆锥角膜患者行光折变角膜切除术(PRK)和角膜胶原交联术(CXL)的视力、屈光度和临床疗效。方法:术后1mo, 3mo, 6mo and 12mo对34例患者未矫正视力(UDVA)和矫正距离视力(CDVA),平、陡角膜测量读数以及并发症进行评估。结果:共34例患者平均年龄为23.3±4.0岁。UDVA和CDVA显著提高,且术后1a恢复平稳。通过超过1a的定期随访,T检验显示术前术后值有显著不同(P<0.05)包括视力,球面和柱面变化。Fourier术后图像分析显示轴向位移垂直于术前轴。结论:非角膜地形图引导PRK联合CXL对于治疗圆锥角膜是一种安全有效的手术选择,能够提高UDVA,CDVA和屈光状态。术后3mo达到稳定状态,与非角膜地形图引导PRK相比,地形图引导的唯一优势可能是通过Fourier术后分析,在某些患者中,球镜和柱镜轴位漂移。 | Suzan Amana Rattan Seif Alshamarti Khalil M Al-Salem Mahir kadhim Mutashar | 2019 | 国际眼科杂志2019，19，3： | 0 |
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