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| 1 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 2 | Expression of bone mor- phogenetie protein messenger RNAs by normal rat and human pros- tate and prostate cancer cells 显示文摘 | Harris S E Harris M A Mahy P | 1994 | Prostate1994，24，4： | 1 |
| 3 | Imaging features of CNS tuberculosis显示文摘 | Semlali S E1 Kharras A Mahi M | 2008 | J Radio|2008，89，2： | 1 |
| 4 | Calculation of color gamuts based on the Neugebauer model显示文摘 | Mahy M | 1997 | Col Res Appl1997，22，： | 1 |
| 5 | Calculationof Color Gamuts Based on the Neugebauer Model 显示文摘 | MAHY M | 1997 | Color Research and Application1997，22，6： | 1 |
| 6 | Les aspects en imagerie de la tuberculose du systeme nerveux central 显示文摘 | Semlali S E1 Kharras A Mahi M | 2008 | J Radiol2008，89，2： | 1 |
| 7 | New case of abdominal pregnancy显示文摘 | Mahi M Boumdin H Chaouir S | 2002 | J Radiol2002，83，728： | 1 |
| 8 | Hoffa diease显示文摘 | Mahi M Brance A Bucca C | 1991 | Ital J Orthop Traumatol1991，17，2： | 1 |
| 9 | Preclinical validation of the hypoxla tracer 2- (2-nitroimidazol-1-yl)-N-( 3,3,3- trifluoropropyl) acetamide, EF3 显示文摘 | Mahy P De Bast M Leveque PH | 2004 | Eur J Nucl Med Mol Imaging2004，31，： | 1 |
| 10 | Modeling the flexural behavior of sandwich composite materials under cyclic fatigue 显示文摘 | Mahi E A Khawar F M Sahraoui S | 2009 | Materials & Design2009，25，3： | 1 |
| 11 | Imaging features of CNS tu- berculosis显示文摘 | Sem lali S EI Kharras A Mahi M | 2008 | J Radiaol2008，89，： | 1 |
| 12 | Decision support system for selecting theproper project delivery method using analytical hierarchy pro-cess 显示文摘 | Mahi I M Alreshaid K | 2005 | Intemational Journal of Project Management2005，23，7： | 1 |
| 13 | A case report of Sandhoff disease显示文摘 | Saouab R Mahi M Abilkacem R | 2011 | Clin Neuroradiol2011，21，： | 1 |
| 14 | Stiffness reduction and energy release rate of cross-ply laminates during fatigue tests显示文摘 | El Mahi A Berthelot J M Brillaud J | 1995 | Composite Structures1995，30，2： | 1 |
| 15 | Decision support system for selecting the proper project delivery method using analytical hierarchy process显示文摘 | Mahi I M Alreshaid K | 2005 | International Journal of Project Management2005，23，7： | 1 |
| 16 | Analysis of duration of risk behaviour for key populations: a literature review 显示文摘 | Fazito E Cuchi P Mahy M | 2012 | Sex Transm Infect2012，882，： | 1 |
| 17 | Modeling the flexural behavior of sandwich composite materials under cyclic fatigue 显示文摘 | Mahi A E Farooq M K Sahraoui S | 2004 | Materials and Design2004，25，2： | 1 |
| 18 | New case of abdominal pregnancy显示文摘 | Mahi M Boumdin H Chaouir S | 2002 | J Radiol2002，83，： | 1 |
| 19 | Does wage dispersion make all firms productive? 显示文摘 | MAHY B RYCX F VOLRAL M | 2011 | Scottish Journal of Political Economy2011，58，4： | 1 |
| 20 | Imaging features of CNS tuberculosis显示文摘 | Semlali S El Kharras A Mahi M | 2008 | J Radiol2008，89，2： | 1 |
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