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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Low-frequency Dilational Elasticity of the Nematic 4'-Pentyl-4-biphenylcarbonitrile (5CB)/Water Interface显示文摘 | E1-Sadek R I Roushdy M Magda J J | 2007 | Langmuir2007，23，15： | 1 |
| 3 | Group classification and exact solutions of nonlinear wave equations显示文摘 | Lahno V I Zhdanov R Z Magda O | 2006 | Acta Appl Math2006，91，3： | 1 |
| 4 | Group classification and exact solations of nonlinear wave equations 显示文摘 | LAHNO V I ZHDANOV R Z MAGDA O | 2006 | Acta Appl Math2006，91，： | 1 |
| 5 | Molecular dynamics of flow in micro-pores显示文摘 | BITSANIS I MAGDA J | 1987 | J Chem Phys1987，87，3： | 1 |
| 6 | Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma显示文摘 | Staquicini Fernanda I Ozawa Michael G Moya Catherine A Driessen Wouter H P Barbu E Magda Nishimori Hiroyuki Soghomonyan Suren Flores Leo G Liang Xiaowen Paolillo Vincenzo Alauddin Mian M Basilion James P Furnari Frank B Bogler Oliver Lang F | 2011 | Journal of Clinical Investigation2011，，1： | 1 |
| 7 | The effect of mature broodstock origin on the spawning efficiency of grey mullet, Mugil cephalus 显示文摘 | Mostfa A M Noba A K Magda I Z | 2013 | Egyp J Histol2013，36，2： | 1 |
| 8 | Molecular dynamics of flow in micropores 显示文摘 | Bitsanis I Magda J J Tirrell M | 1987 | Journal of Chemical Physics1987，87，3： | 1 |
| 9 | Impact of landfill leachate on the groundwater quality:a case study in Egypt显示文摘 | MAGDA M A GABER I A | 2015 | Journal of Ad vanced Research2015，6，4： | 1 |
| 10 | Phytosterols:Physiologic and metabolic aspects related tocholesterol-lowering properties显示文摘 | Gemma B Miguel I A C Magda R | 2008 | Nutrition Research2008，28，： | 1 |
| 11 | Group classification and exact solations of nonlinear wave equations显示文摘 | Lahno V I Zhdanov R Z Magda O | 2006 | Acta Appl Math2006，91，： | 1 |
| 12 | Catalase effects on glucose-sensitive hydrogels显示文摘 | Jung D Y Magda J J Han I S | | 0，，09： | 1 |
| 13 | Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and AP- CI LC/MS/MS for chlorpheniramine in humanplasma and the importance of multiple source ma trix effect evaluations显示文摘 | OMNIA I A MATTHEW H S MAGDA E Y | 2008 | J Chromatogr B2008，875，2： | 1 |
| 14 | Room-temperature magnetic order on zigzag edges of narrow graphene nanorib- bons显示文摘 | MAGDA G Z JIN X HAGYMASI I | 2014 | Nature2014，514，7524： | 1 |
| 15 | Wage differentials across sectors in Europe显示文摘 | Magda I Rycx F | 2011 | Economics of Transition2011，19，4： | 1 |
| 16 | Design,synthesis,and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors:Molecular docking study显示文摘 | Magda A-A El-Sayed Naglaa I Abdel-Aziz Alaa A-M AbdelAziz | 2011 | Bioorg Med Chem2011，19，： | 1 |
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