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| 1 | Aquaporins in the central nervous system显示文摘 | Venero J L Vizuete M L Machado A | 2001 | Prog Neurobiol2001，63，3： | 1 |
| 2 | Floating photocatalysts based on TiO2 supported on high surface area exfoliated vermiculite for water decontamination显示文摘 | Machado L C R Torchia C B Lago R M | 2006 | Catal Com2006，7，： | 1 |
| 3 | Effect of milk fatand total solids concentration on the kinetics of moistureuptake by ready-to-eat breakfast cereal 显示文摘 | Machado M F Oliveira FAR Cunha L M | 1999 | InternationalJournal of Food Science and Technology1999，34，1： | 1 |
| 4 | Evaluation of insecticidal activity of diterpenes and lignans from Aristolochia malmeana against Anticarsia gemmatalis 显示文摘 | Messiano G B Vieira L Machado M B | 2008 | JAgric Food Chem2008，56，： | 1 |
| 5 | Cardiovascular risk in peritoneal dialysis-a Portuguese multicenter study显示文摘 | Neves M Machado S Rodrigues L | 2014 | Nefrologia2014，34，2： | 1 |
| 6 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 7 | Below -ground resourceslimit seedling growth in forest understories but do not alterbiomass distribution显示文摘 | Machado J L Walters M B | 2003 | Annual Forestry Science2003，60，： | 1 |
| 8 | Gain -of- function mutations of ARHGAP31, a Cdc42/Racl GTPase regulator, cause syndromic curls aplasia and limb anomalies 显示文摘 | Southgate L Machado R D Snape K M | 2011 | Am J Hum Genet2011，88，5： | 1 |
| 9 | Effect of light and temperature on the formation of glyeoalkaloids in potato tubers 显示文摘 | Machado R M D Toledo M C F Garcia L C | 2007 | Food Control2007，18，5： | 1 |
| 10 | Oil analysis of Guazuma ulmifolia leaves显示文摘 | Arriaga A M Machado M I L Craveiro A A | 1996 | Rev Brasile Farm1996，77，19： | 1 |
| 11 | Accompanying of parameters of color, gloss and hardness on polymeric films coated with pigmented inks cured by different radiation doses of ultraviolet light 显示文摘 | Bardi M A G Machado L D B | 2012 | Radiation Physics and Chemistry2012，81，9： | 1 |
| 12 | Constitutive Model for Municipal Solid Waste 显示文摘 | Machado S L Carvalho M F Vilar O M | 2002 | Journal of Geotechnical and Geoenviron-mental Engineering2002，128，11： | 1 |
| 13 | Regeneration of transgenic plants of Prunus armeniaca containing the coat protein gene of Plum Pox Virus显示文摘 | da CAMARA MACHADO M L da CAMARA MACHADO A HANZER V WEISS H REGNER F STEINKELINER H | 1992 | Plant Cell Rep1992，11，： | 1 |
| 14 | Application of a Meshless Method in Electromagnetic 显示文摘 | Yang S L Ho Machado J M Wong H C | 2001 | IEEE Trans Mag2001，，5： | 1 |
| 15 | Prog- nostic score in gastric cancer:the importance of a conjoint anal- ysis of clinical, pathologic, and therapeutic factors显示文摘 | Costa M L de Cassia Braga Ribeiro K Machado M A | 2006 | Ann Surg 0ncol2006，13，6： | 1 |
| 16 | A study of the influence of the synthesis conditions upon the catalytic properties of silicoaluminophosphate molecular sieves显示文摘 | L'opez C M Machado F J Mendez B | 2000 | Topics in Catalysis2000，，10： | 1 |
| 17 | Effects of storing pig ovaries at 4 or 20°C for different periods of time on the morphology and viability of pre-antral follicles显示文摘 | Lucci C M Schreier L L Machado G M | 2007 | Reprod Dom Anim2007，42，1： | 1 |
| 18 | A Modified Ant Colony Optimization Algorithm Modeled on Tabu-Search Methods 显示文摘 | Ho S L Yang S Ni G Machado J M | 2006 | IEEE Transactions on Magnetics (S0018-9464)2006，42，2： | 1 |
| 19 | Oil analysis of Guazuma ulmifolia leaves显示文摘 | ARRIAGA A M MACHADO M I L CRAVEIRO A A | 1996 | Rev Brasile Farm1996，77，： | 1 |
| 20 | Antimicrobial peptides and immunolocalization of a LTP in vigna unguiculata seeds 显示文摘 | CARVALHO A O MACHADO O L T da CUNHA M | 2001 | Plant Physiogy and Biochemistry2001，39，： | 1 |
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