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| 1 | Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome显示文摘 | MantovaniG MadedduC MacciòA | 2013 | Drug Des Devel Ther2013，7，： | 1 |
| 2 | Inflammation and ovarian cancer显示文摘 | Antonio Macciò Clelia Madeddu | 2012 | Cytokine2012，，2： | 1 |
| 3 | Inflammation and ovarian cancer显示文摘 | Antonio Macciò Clelia Madeddu | 2012 | Cytokine2012，，2： | 1 |
| 4 | Correlation of body mass index and leptin with tumor size and stage of disease in hormone-dependent postmenopausal breast cancer:preliminary results and therapeutic implications显示文摘 | Macciò A Madeddu C Gramignano G | 2010 | J Mol Med (Berl)2010，88，7： | 1 |
| 5 | Comparison of granisetron,ondansetron and tropisetron in the prophylaxis of acute nausea and vomiting induced by cisplatin for the treatment of head and neck cancer:a randomised controlled trial显示文摘 | Mantovani G Macciò A Bianchi A | 1996 | Cancer1996，77，5： | 1 |
| 6 | Randomized phaseⅢclinical trial of five different arms of treatment in 332 patients with cancer cachexia显示文摘 | Mantovani G MacciòA Madeddu C | 2010 | Oncologist2010，15，2： | 1 |
| 7 | Laparoscopic management of a giant mucinous benign ovarian mass weighing 10150 grams:A case report显示文摘BACKGROUND Giant ovarian cysts(≥15 cm in diameter)are rare.The size limit of cysts and the methodology for a safe and successful minimally invasive surgery has not been established.Here we report a case of a large 10-kg multi-locular ovarian mass,which was successfully laparoscopically removed:Our aim was to innovate the surgical practice in this field by providing a safe,effective,and minimally invasive management method for such complex and rare cases.CASE SUMMARY A 49-year-old nulliparous woman presented with abdominal distension,lasting from six Mo prior to admission;she reported worsening abdominal pain,abdominal swelling,and mild dyspnea.Imaging showed a presumed benign multi-locular(>10 locules)left ovarian cyst that measured about 30 cm in diameter.Based on the IOTA-ADNEX model the mass had a 27.5%risk of being a borderline or malignant tumor.The patient was successfully treated via a direct laparoscopic approach with salpingo-oophorectomy,followed by the external drainage of the cyst.Tumor spillage was successfully avoided during this procedure.The final volume of the drained mucinous content was 8950 L;the cyst wall,extracted through the minilaparotomy,weighed about 1200 g.The pathologic gross examination revealed a 24 cm×15 cm×10 cm mass;the histologic examination diagnosed a mucinous cystoadenoma.To our knowledge,this is the first case of a giant multi-locular ovarian cyst treated with a direct laparoscopy with salpingo-oophorectomy followed by external decompression.CONCLUSION Choosing the appropriate technique and surgeon skill are necessary for a safe and effective minimally-invasive approach of unique cases involving giant ovarian cysts. | Elisabetta Sanna Clelia Madeddu Luca Melis Sonia Nemolato Antonio Macciò | 2020 | World Journal of Clinical Cases2020，8，16： | 1 |
| 8 | Novel technique of extracorporeal intrauterine morcellation after total laparoscopic hysterectomy: Three emblematic case reports显示文摘BACKGROUND In the presence of a large uterus,total laparoscopic hysterectomy(TLH),always requires morcellation to allow removal of the tissues from the abdominal cavity.However,uncontained morcellation has been scrutinized because of the possible spread of occult leiomyosarcoma.Therefore,in-bag extracorporeal morcellation has been developed.However,tissue containment and extraction are extremely challenging,especially when considering the increasing uterine size to be removed through minimally invasive surgery.CASE SUMMARY Herein,we describe a novel technique for extracorporeal intrauterine morcellation using the uterus outermost layer as a bag to achieve tissue extraction of very large uteri with suspected occult leiomyosarcoma after TLH.The study enrolled patients who were planned for TLH for large uteri(weight>500 g).TLH was performed following the procedure reported in our previous studies.The novel technique has been described step-by-step in a video,which representatively describes the preoperative imaging and morcellation procedure of three very large uteri weighing 1500 g,1700 g,and 3700 g,respectively.The procedures were performed without any complications.The patients had an uneventful postoperative course,and in all cases,the pathology was benign leiomyoma.CONCLUSION Extracorporeal intrauterine morcellation using the uterus outmost layer as a bag was found to be a feasible technique that allows a careful diagnosis and safe removal of suspected occult malignancies.The technique herein presented may be adopted in surgical practice,by adding it to the other available techniques of contained morcellation.It may represent a valid and feasible alternative,especially useful in cases of very large uteri exceeding the capacity of specimen retrieval bags. | Antonio Macciò Elisabetta Sanna Fabrizio Lavra Piergiorgio Calò Clelia Madeddu | 2021 | World Journal of Clinical Cases2021，9，20： | 1 |
| 9 | In vitro corrosion behaviour of Ti–Nb–Sn shape memory alloys in Ringer’s physiological solution显示文摘 | F. Rosalbino D. Macciò G. Scavino A. Saccone | 2012 | Journal of Materials Science: Materials in Medicine2012，，4： | 1 |
| 10 | Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel Disease显示文摘 | Marzena Komraus Halina Wos Sabina Wiecek Maciej Kajor Urszula Grzybowska-Chlebowczyk Antonio Macciò | 2012 | Mediators of Inflammation2012，，： | 1 |
| 11 | Laparoscopic hysterectomy as optimal approach for 5400 grams uterus with associated polycythemia: A case report显示文摘BACKGROUND Uterine myomas are the most common benign gynecological soft tissue tumors in women but polycythemia associated with these tumors is rare.Polycythemia is significantly associated with risk of venous thromboembolism(VTE),which is further increased in case of a large pelvic mass and obesity.Here we report the surgical challenges in the case of an obese patient with a giant fibromatous uterus and associated polycythemia.CASE SUMMARY A 42-year-old obese woman was referred to our department for treatment for a huge fibromatous uterus.She suffered of pelvic pressure and abdominal distension and reported severe dyspnea from several months.Laboratory analyses including hemoglobin(Hb)19.2 g/dL and hematocrit(Hct)59.7%were indicative of polycythemia.Arterial blood gas analysis showed arterial oxygen pressure(pO2)of 81.5 mmHg.Abdominal computed tomography confirmed a giant fibromatous uterus measuring 28.2 cm×17 cm×25 cm.To reduce the thromboembolic risk,the patient underwent low molecular weight heparin,phlebotomy twice before surgery,and we opted for a laparoscopic hysterectomy.The uterus weighed 5400 g and the histology confirmed a diagnosis of leiomyoma.We did not find increased erythropoietin levels in the supernatant of the myomatous uterine tissue.There were no complications.On postoperative day 1,the Hb and the Hct levels normalized to 13.3 g/dL and 41.7%,respectively.Arterial blood gas analysis after surgery showed a pO2 of 144.7 mmHg.These results suggested the diagnosis of myomatous erythrocytosis syndrome.The patient was discharged on the second postoperative day in very good condition with no symptoms.CONCLUSION We believe this is the first reported laparoscopic hysterectomy in a patient with a giant uterus,polycythemia and obesity.Multiple VTE risk factors warranted a laparoscopic approach. | Antonio Macciò Giacomo Chiappe Fabrizio Lavra Elisabetta Sanna Romualdo Nieddu Clelia Madeddu | 2019 | World Journal of Clinical Cases2019，7，19： | 5 |
| 12 | Multifaceted relationship between diabetes and kidney diseases:Beyond diabete显示文摘Diabetes mellitus is one of the most common causes of chronic kidney disease.Kidney involvement in patients with diabetes has a wide spectrum of clinical presentations ranging from asymptomatic to overt proteinuria and kidney failure.The development of kidney disease in diabetes is associated with structural changes in multiple kidney compartments,such as the vascular system and glomeruli.Glomerular alterations include thickening of the glomerular basement membrane,loss of podocytes,and segmental mesangiolysis,which may lead to microaneurysms and the development of pathognomonic Kimmelstiel-Wilson nodules.Beyond lesions directly related to diabetes,awareness of the possible coexistence of nondiabetic kidney disease in patients with diabetes is increasing.These nondiabetic lesions include focal segmental glomerulosclerosis,IgA nephropathy,and other primary or secondary renal disorders.Differential diagnosis of these conditions is crucial in guiding clinical management and therapeutic approaches.However,the relationship between diabetes and the kidney is bidirectional;thus,new-onset diabetes may also occur as a complication of the treatment in patients with renal diseases.Here,we review the complex and multifaceted correlation between diabetes and kidney diseases and discuss clinical presentation and course,differential diagnosis,and therapeutic opportunities offered by novel drugs. | Pasquale Esposito Daniela Picciotto Francesca Cappadona Francesca Costigliolo Elisa Russo Lucia Macciò Francesca Viazzi | 2023 | World Journal of Diabetes2023，14，10： | 0 |
| 13 | 显示文摘 | Giovanni Mantovani Antonio Macciò Loredana Mura Elena Massa Maria Caterina Mudu Carlo Mulas Maria Rita Lusso Clelia Madeddu Annita Dessì | 2000 | Journal of Molecular Medicine2000，，10： | 1 |
| 14 | Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib ± megestrol acetate for patients with cancer-related anorexia/cachexia syndrome显示文摘 | Clelia Madeddu Mariele Dessì Filomena Panzone Roberto Serpe Giorgia Antoni Maria Chiara Cau Lorenza Montaldo Quirico Mela Marco Mura Giorgio Astara Francesca Maria Tanca Antonio Macciò Giovanni Mantovani | 2011 | Clinical Nutrition2011，，2： | 1 |
| 15 | Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results显示文摘 | Giovanni Mantovani Antonio Macciò Clelia Madeddu Giulia Gramignano Roberto Serpe Elena Massa Mariele Dessì Francesca Maria Tanca Eleonora Sanna Laura Deiana Filomena Panzone Paolo Contu Carlo Floris | 2008 | Nutrition2008，，4： | 1 |
| 16 | Effectiveness and safety of antithrombotic strategies in elderly patients with acute myocardial infarction显示文摘BACKGROUND Elderly patients represent a rapidly growing part of the population more susceptible to acute coronary syndromes and their complications.However,literature evidence is lacking in this clinical setting.AIM To describe the clinical features,in-hospital management and outcomes of“elderly”patients with myocardial infarction treated with antiplatelet and/or anticoagulation therapy.METHODS This study was a retrospective analysis of all consecutive patients older than 80 years admitted to the Division of Cardiology of St.Andrea Hospital of Vercelli from January 2018 to December 2018 due to ST-elevation myocardial infarction(STEMI)or non-ST elevation myocardial infarction(NSTEMI).Clinical and laboratory data were collected for each patient,as well as the prevalence of previous or in-hospital atrial fibrillation(AF).In-hospital management,consisting of an invasive or conservative strategy,and the anti-thrombotic therapy used are described.Outcomes evaluated at 1 year follow-up included an efficacy ischemic endpoint and a safety bleeding endpoint.RESULTS Of the 105 patients enrolled(mean age 83.9±3.6 years,52.3%males),68(64.8%)were admitted due to NSTEMI and 37(35.2%)due to STEMI.Among the STEMI patients,34(91.9%)underwent coronary angiography and all of them were treated with percutaneous coronary intervention(PCI);among the NSTEMI patients,42(61.8%)were assigned to an invasive strategy and 16(38.1%)of them underwent a PCI.No significant difference between the groups was found concerning the prevalence of previous or in-hospital de-novo AF.10.5%of the whole population received triple antithrombotic therapy and 9.5%single antiplatelet therapy plus oral anticoagulation(OAC),with no significant difference between the subgroups,although a higher number of STEMI patients received dual antiplatelet therapy without OAC as compared with NSTEMI patients.A low rate of in-hospital death(5.7%)and 1-year cardiovascular death(3.3%)was registered.Seven(7.8%)patients experienced major adverse cardiovascular events,while the rate of minor and major bleeding at 1-year follow-up was 10%and 2.2%,respectively,with no difference between NSTEMI and STEMI patients.CONCLUSION In this real-world study,a tailored evaluation of an invasive strategy and antithrombotic therapy resulted in a low rate of adverse events in elderly patients hospitalized with acute myocardial infarction. | Elisa Rondano Marzia Bertolazzi Alessandro Galluzzo Ludovica Maltese Paolo Caccianotti Sergio Macciò Stefano Mazza Maria Virginia Di Ruocco Serena Favretto Eraldo Occhetta Francesco Rametta | 2020 | World Journal of Cardiology2020，12，11： | 1 |
| 17 | l -Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer显示文摘 | Sílvia Busquets Roberto Serpe Míriam Toledo Angélica Betancourt Enrica Marmonti Marcel Orpí Fabrizio Pin Eva Capdevila Clelia Madeddu Francisco J. López-Soriano Giovanni Mantovani Antonio Macciò Josep M. Argilés | 2012 | Clinical Nutrition2012，，6： | 2 |
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