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| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | The first documented case of brucello- sis manifested with pancytopenia and capillary leak syndrome 显示文摘 | Erkurt MA Sail I Gul HC | 2008 | In- tern Med2008，47，： | 1 |
| 3 | Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term-potentiation in rats显示文摘 | Wang HL Wu HC | 1998 | Neuroscience1998，82，4： | 1 |
| 4 | Dual suppression with oral contraceptives and gonadotrophin releasing-hormone agonists improves in-vitro fertilization outcome in high responder patients显示文摘 | Damario MA Barmat L Liu HC | 1997 | Hum Reprod1997，12，11： | 1 |
| 5 | Bioaugmented cellulosic hydrogen production from cornstalk by integrating dilute acid-enzyme hydrolysis and dark fermentation显示文摘 | Pan CM Ma HC Fan YT | 2011 | International Journal of Hydrogen Energy2011，36，8： | 1 |
| 6 | Agenesis of the cor- pus callosum in California 1983-2003 : A population - based study 显示文摘 | Glass HC Shaw GM Ma C | 2008 | Am J Med Genet A2008，146，19： | 1 |
| 7 | Hyperpolarization and slowing of the rate of contraction in human uterus in pregnancy by prostaglandins E2 and F2a; involvement of the Na~ pump显示文摘 | Parking'ton HC Tonta MA Davies NK | 1999 | J Physiol1999，514，1： | 1 |
| 8 | Comparison of corneal wavefront aberrations after photorefractive keratectomy and laser in situ keratomileusis显示文摘 | Oshika T Klyce SD Applegate RA Howland HC El Danasoury MA | 1999 | Am J Ophthalmol1999，127，1： | 1 |
| 9 | Experimental models of traumatic axonal injury 显示文摘 | Wang HC Ma YB | 2010 | Journal of Clinica| Neuroscience2010，17，2： | 1 |
| 10 | Elevated plasma endothelin in patient with diabetes mellitus 显示文摘 | Takahashi K Ghatei MA Lam HC | 1990 | Diabetologia1990，33，5： | 1 |
| 11 | Medical genetictest reporting in molecular cystic fibrosis and factor Ⅴ Leiden in North American laboratories显示文摘 | Andersson HC Krousel-Wood MA Jackson K | 2002 | Cenet Med2002，4，： | 1 |
| 12 | High - dose vs non - high - dose proton pump inhibitors after endoscopic treatment in patients with bleeding peptic ulcer: a systematic review and meta - analysis of ran- domized controlled trims 显示文摘 | Wang CH Ma MH Chou HC | 2010 | Arch Intern Med2010，170，9： | 1 |
| 13 | Antinociceptive and sedative effects induced by carbachol and oxycodone into brain stem potine reticular formation in rats显示文摘 | Ma HC Dohi Si Wang YF | 2001 | Anesth Analg2001，92，： | 1 |
| 14 | PI3K and RAC signalling in leukocyte and cancer cell migration显示文摘 | Barber MA Welch HC | 2006 | Bull Cancer2006，93，5： | 1 |
| 15 | Prevalence and predictors of depression and anxiety-related disorders during the year after heart transplantation 显示文摘 | DEW MA ROTH LH SCHULBERG HC | 1996 | Gen Hosp Psychiatry1996，18，6： | 1 |
| 16 | Overpowering the Crankshaft Mechanism:The Effect of Posterior Spinal Fusion With and Without stiff Transpedicular Fixation on Anterior Spinal Column Growth in Immature Canines显示文摘 | Asher MA Lark RG | 1996 | Spine1996，21，10： | 1 |
| 17 | Brain derived neurotrophic factor antisens oligonucleotide impairs memory retention and inhibits long- term potentiation in rat 显示文摘 | Ma YL Wang HL Wu HC | 1998 | Neuroaci1998，82，： | 1 |
| 18 | Aberrant regulation and function of Src family tyrosine kinases: their potential contributions to glutamate-induced neurotoxicity 显示文摘 | Hossain MI Kamamddin MA Cheng HC | 2012 | Clin Exp Pharmacol Physiol2012，39，8： | 1 |
| 19 | Removing endotoxin from plasmid samples by Triton X-114 isothermal extraction显示文摘 | Ma R Zhao J Du HC | 2012 | Anal Biochem2012，424，2： | 1 |
| 20 | Joint replacement for anky- losed hips显示文摘 | Kilgus DJ Amstutz HC Wolgin MA | 1990 | J Bone Joint Surg Am1990，72，： | 1 |
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