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| 1 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 2 | Comparative study on skin temperature response to menstruation at acupuncture points in healthy volunteers and primary dysmenorrhea patients显示文摘OBJECTIVE:To assess skin temperature response to menstruation at acupuncture points in primary dysmenorrhea(PD) patients and healthy volunteers so as to explore acupuncture point specificity in reflecting diseases in the light of skin temperature.METHODS:Fifty-two PD patients and 49 healthy volunteers were recruited.Skin temperature measurements were performed with a skin temperature assessment device at 10 points.Absolute difference between skin temperature of the same point on the left and right side is used as main outcome measure.RESULTS:On the first day of menstruation, when menstrual pain attacking in PD patients, a significant increase in skin temperature difference was detected at Taixi(KI 3) compared with the healthy group(P < 0.01).A significant reduction in skin temperature difference was detected at Taixi(KI 3) in the first day of menstruation compared with those values in the third day after menstruation(P < 0.01)in the healthy group.On the third day after menstruation, a significant reduction in skin temperature difference was found at Zhongdu(LR 6) in PD group compared with the healthy group(P < 0.05).No significant differences of skin temperature were detected at other points(P > 0.05).CONCLUSION:The skin temperature difference at menstruation-relevant points in PD patients did not all change significantly more than those in women without PD.Significant difference was only found in Taixi(KI 3), the Yuan-source point of Kidney meridian. | She Yanfen Ma Liangxiao Zhu Jiang Qi Conghui Wang Yanxia Tang Ling Li Chunhua Yuan Hongwen Liu Yuqi Song Jiashan | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 8 |
| 3 | Hospital-Based Phenotypic Features and Treatment Outcomes of Chinese Women with Polycystic Ovary Syndrome: The Effect of Body Mass Index and Geographic Distribution显示文摘Genetic,lifestyle,and environmental factors contribute to the etiology of polycystic ovary syndrome(PCOS).Increased body mass index(BMI)exacerbates the reproductive and metabolic parameters and reduces the fecundity of women with PCOS.This is a secondary analysis of a large-sample,multicenter,randomized controlled trial conducted at 21 sites in Chinese mainland.A total of 1000 women diagnosed with PCOS were enrolled in this trial.Of these,998 women with PCOS were included in the analysis.Increased BMI was associated with more severe menstrual irregularities,elevated testosterone level,higher prevalence of metabolic syndrome,and poorer quality of life.The rates of ovulation per woman for the normal,overweight,and obese BMI groups were 83.0%,78.2%,and 63.6%,respectively(P<0.001),and the rates of live birth were 23.6%,18.1%,and 15.3%(P=0.030).Northern PCOS patients showed more severe reproductive,glucose,and lipid profiles;less exercise;and lower total ovulation rates compared with PCOS patients from Southern China(74.8%vs 81.2%,absolute difference 6.4%,95%confidence interval 1.2%–11.5%).The results show the typical phenotypic features of Han women with PCOS in Northern and Southern China.The women living in Northern China showed a higher BMI,more severe glycolipid metabolism profiles,and subsequently worse clinical outcomes by the same interventions than those living in Southern China.The difference in phenotypic features can be explained mostly by differences in BMI and the resulting difference in ovulation. | Jingshu Gao Hongli Ma Yu Wang Xinming Yang Yijuan Cao Bei Zhang Conghui Han Xiaoke Wua | 2021 | Engineering2021，7，2： | 3 |
| 4 | The impact of sample processing on the rapid antigen detection test for SARS-CoV-2: Virus inactivation, VTM selection, and sample preservation显示文摘Many factors have been identified as having the ability to affect the sensitivity of rapid antigen detection(RAD)tests for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).This study aimed to identify the impact of sample processing on the sensitivity of the RAD tests.We explored the effect of different inactivation methods,viral transport media(VTM)solutions,and sample preservation on the sensitivity of four RAD kits based on two SARS-CoV-2 strains.Compared with non-inactivation,heat inactivation significantly impacted the sensitivity of most RAD kits;however,β-propiolactone inactivation only had a minor effect.Some of the VTM solutions(VTM2,MANTACC)had a significant influence on the sensitivity of the RAD kits,especially for low viral-loads samples.The detection value of RAD kits was slightly decreased,while most of them were still in the detection range with the extension of preservation time and the increase of freeze–thaw cycles.Our results showed that selecting the appropriate inactivation methods and VTM solutions is necessary during reagent development,performance evaluation,and clinical application。 | Haiwei Zhou Conghui Wang Jian Rao Lan Chen Tingting Ma Donglai Liu Lili Ren Sihong Xu | 2021 | Biosafety and Health2021，3，5： | 3 |
| 5 | Evidence for the paternal mitochondrial DNA in the crucian carp-like fish lineage with hybrid origin显示文摘In terms of taxonomic status,common carp(Cyprinus carpio,Cyprininae)and crucian carp(Carassius auratus,Cyprininae)are different species;however,in this study,a newborn homodiploid crucian carp-like fish(2n=100)(2nNCRC)lineage(F1–F3)was established from the interspecific hybridization of female common carp(2n=100)×male blunt snout bream(Megalobrama amblycephala,Cultrinae,2n=48).The phenotypes and genotypes of 2 n NCRC differed from those of its parents but were closely related to those of the existing diploid crucian carp.We further sequenced the whole mitochondrial(mt)genomes of the 2n NCRC lineage from F1 to F3.The paternal mt DNA fragments were stably embedded in the mt-genomes of F1–F3 generations of 2n NCRC to form chimeric DNA fragments.Along with this chimeric process,numerous base sites of F1–F3 generations of 2 n NCRC underwent mutations.Most of these mutation sites were consistent with the existing diploid crucian carp.Moreover,the mt DNA organization and nucleotide composition of 2n NCRC were more similar to those of the existing diploid crucian carp than those of the parents.The inheritable chimeric DNA fragments and mutant loci in the mt-genomes of different generations of 2nNCRC provided important evidence of the mt DNA change process in the newborn lineage derived from hybridization of different species.Our findings demonstrated for the first time that the paternal mt DNA were transmitted into the mt-genomes of homodiploid lineage,which provided new insights into the existence of paternal mt DNA in the mt DNA inheritance. | Shi Wang Ni Jiao Lu Zhao Meiwen Zhang Pei Zhou Xuexue Huang Fangzhou Hu Conghui Yang Yuqin Shu Wuhui Li Chun Zhang Min Tao Bo Chen Ming Ma Shaojun Liu | 2020 | Science China(Life Sciences)2020，63，1： | 2 |
| 6 | Asymmetric Regulation System Fit for Chinese Telecom Market显示文摘After the new round of restructuring of Chinese telecom sector,it's pressing to formulate and implement asymmetric regulation policies so as to shape an effectively competitive market structure in a relatively short term.This paper reviewed the asymmetric regulation policies and practices carried out in foreign telecom market,and then according to the specific situations of Chinese telecom market,proposed the principles and corresponding policies for establishing an asymmetric regulation system fit for Chinese telecom market. | Shi Wei Zhao Xuefeng Ma Conghui | 2008 | China Communications2008，5，3： | 2 |
| 7 | Analysis of the formation process and performance of magnetic Fe_3O_4@Poly(4-vinylpyridine) absorbent prepared by in-situ synthesis显示文摘The morphology evolution of the mesoporous magnetic composite nanospheres Fe_3O_4@Poly(4-vinylpyridine) during the formation process and its absorption property of Congo red were studied in this study. A simple solvothermal method was applied for the fabrication of Fe_3O_4@Poly(4-vinylpyridine)composites with regular structure and uniform size distribution in the presence of 4-vinylpyridine as the structure inducer. The morphology, structure and magnetism performance were characterized and the adsorption model and mechanism were discussed. The results showed that the Fe_3O_4@Poly(4-vinylpyridine) composites were efficient adsorbent for the removal of Congo red from water and it could be reused by a magnetic separation. The adsorption isotherm of Congo red on Fe_3O_4@Poly(4-vinylpyridine) composites was fitted well with the Langmuir adsorption model. | Birong Zeng Li Yang Wei Zheng Jihong Zhu Xiaojun Ma Xinyu Liu Conghui Yuan Yiting Xu Lizong Dai | 2018 | Journal of Materials Science & Technology2018，34，6： | 1 |
| 8 | Implications of the U.S.Financial Crisis for the Development of China's Telecom Sector显示文摘The financial turbulence caused by the U.S.subprime crisis has a far-reaching impact on the global financial system and economic development.Based on an in-depth analysis of the cause of U.S.subprime crisis and its effects on China and global economy,in combi-nation with the current status of China's telecom sector,this article puts forward policy suggestions for the de-velopment and regulation of China's telecom sector. | Shi Wei,Ma Conghui,Zhao Xuefeng Institute of Economic System and Management,National Development and Reform Commission,Beijing,100035,P.R.C | 2008 | China Communications2008，5，4： | 1 |
| 9 | Monitoring study on technology of the cooling roadbed in permafrost region of Qinghai Tibet plateau 显示文摘 | Ma Wei Shi Conghui Wu Qingbai | 2006 | Cold Regions Science and Technology2006，44，1： | 1 |
| 10 | Selection of reference genes for reverse transcription quantitative real- time PCR normalization in black rockfish (Sebastes schlegeli)显示文摘 | MA Liman WANG Wenji LIU Conghui | 2013 | Marine Genomics2013，11，： | 1 |
| 11 | Strain transfer behavior and crystallographic mechanism of crack initiation during cyclic deformation in zirconium显示文摘Fully-reversed cyclic deformation of a pure Zr(a thickness of 17 mm)was conducted at two different strain amplitudes(0.4%and 0.8%)to investigate the deformation and crack initiation behaviors based on slip trace analysis.It was found that prismaticaslip with a higher Schmid Factor(m>0.4)was the dominant deformation mode.The grains containing persistent slip bands(PSBs)tended to go towards[1210]pole and the Schmid Factor had a critical value of 0.4 above which prismatic and pyramidal slip were dominant.Fatigue cracks were mainly initiated at PSBs and grain boundaries(GBs).It showed that 61.1%of the cracks were PSB cracks under a strain amplitude of 0.4%,while it decreased to 53.5%at a strain amplitude of 0.8%.PSB cracks were mainly parallel to prismaticaslip with higher Schmid Factor while some cracks tended to be initiated at GBs with higher misorientation angles.The interaction of PSBs with GBs would result in strain transferring to the neighboring grain.Strain transfer was more likely to occur at the condition of the higher geometrical compatibility factor m,and lower residual Burgers vectorb,which could reduce strain localization. | Xiangkang Zeng Conghui Zhang Wenguang Zhu Mingliang Zhu Tongguang Zhai Chi Ma Tingchuang Shu KangKai Song | 2023 | Journal of Materials Science & Technology2023，，31： | 0 |
| 12 | A secreted catalase contributes to Puccinia striiformis resistance to host-derived oxidative stress显示文摘Plants can produce reactive oxygen species(ROS)to counteract pathogen invasion,and pathogens have also evolved corresponding ROS scavenging strategies to promote infection and pathogenicity.Catalases(CATs)have been found to play pivotal roles in detoxifying H_(2)O_(2)formed by superoxide anion catalyzed by superoxide dismutases(SODs).However,few studies have addressed H_(2)O_(2)removing during rust fungi infection of wheat.In this study,we cloned a CAT gene PsCAT1 from Puccinia striiformis f.sp.tritici(Pst),which encodes a monofunctional heme-containing catalase.PsCAT1 exhibited a high degree of tolerance to pH and temperature,and forms high homopolymers.Heterologous complementation assays in Saccharomyces cerevisiae reveal that the signal peptide of PsCAT1 is functional.Overexpression of PsCAT1 enhanced S.cerevisiae resistance to H_(2)O_(2).Transient expression of PsCAT1 in Nicotiana benthamiana suppressed Bax-induced cell death.Knockdown of PsCAT1 using a host-induced gene silencing(HIGS)system led to the reduced virulence of Pst,which was correlated to H_(2)O_(2)accumulation in HIGS plants.These results indicate that PsCAT1 acts as an important pathogenicity factor that facilitates Pst infection by scavenging host-derived H_(2)O_(2). | Pu Yuan Wenhao Qian Lihua Jiang Conghui Jia Xiaoxuan Ma Zhensheng Kang Jie Liu | 2021 | Stress Biology2021，1，1： | 0 |
| 13 | A Study on Corpus Content Display and IP Protection显示文摘 | Jingyi Ma Muyun Yang Haoyong Wang Conghui Zhu Bing Xu | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 0 |
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