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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Penetration of ambient fine particles into the indoor environment显示文摘 | MOSLEY R B GREENWELL D J SPARKS L E | | 0，，01： | 1 |
| 3 | Effects of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | Eldredge E P Holmes Z A Mosley A R Shock C C Stieber T D | | 0，，： | 1 |
| 4 | Sequence variations in PCSK9,low LDL,and protection against coronary heart disease显示文摘 | Cohen JC Boerwinkle E Mosley TH Jr | | 0，，： | 1 |
| 5 | Sequence variations in PCSK9, low LDL, and protection against coronary heart disease显示文摘 | Cohen JC Boerwinkle E Mosley TH Jr | 2006 | N Engl J Med2006，354，： | 1 |
| 6 | Cis-9, trans-ll coniugated linoleic acid is synthesized directly from vaccenic acid in lactating dairy cattle显示文摘 | Mosley E E Shafii B Moate P J | 2006 | Nutr2006，136，： | 1 |
| 7 | 'Recent warming': ice core evidence from tropical ice cores with emphasis on Central Asia显示文摘 | THOMPSON L G MOSLEY T E DAVIS Me | 1993 | Global Planet Change1993，7，13： | 1 |
| 8 | Sequence variations in PCSK9, low LDL, and protec- tion against coronary heart disease 显示文摘 | COHEN J C BOERWINKLE E MOSLEY JR T H | 2006 | New England Journal of Medicine2006，354，12： | 1 |
| 9 | Reflective tomography recon- struction of satellite features-field results 显示文摘 | Matson C L Mosley D E | 2011 | Appl Opt2011，40，14： | 1 |
| 10 | Microbial biohydrogenation of oleic acid to trans isomers in vitro显示文摘 | Mosley E E Powell G L Riley M B | 2002 | J Lipid Res2002，43，： | 1 |
| 11 | Isomerization of stable isotopically labeled elaidic acid to cis and trails monoenes by ruminal microbes显示文摘 | PROELL J M MOSLEY E E POWELL G L | 2002 | J Lipid Res2002，43，12： | 1 |
| 12 | Sequence variations in PCSK9, low ldl, and protection against coronary heart disease显示文摘 | COHEN J BOERWINKLE E MOSLEY TH JR | 2006 | N Engl J Med2006，354，12： | 1 |
| 13 | Sequence variations in PCSK9, low LDL, and protection against coronary heart disease显示文摘 | Cohen JC Boerwinker E Mosley TH | 2006 | N Engl J Med2006，354，： | 1 |
| 14 | Sodium-Glucose Linked Transporter 2(SGLT2)Inhibitors in the Management of Type-2Diabetes:A Drug Class Overview显示文摘 | Mosley JF 2nd Smith L Everton E | 2015 | P T2015，40，7： | 1 |
| 15 | Neuroinflammation,oxidative stress,and the pathogenesis of Parkinson's disease显示文摘 | Mosley R L Benner E J Kadiu I | 2006 | Clin Neurosci Res2006，6，： | 1 |
| 16 | Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease显示文摘 | Benner E J Mosley R L Destache C J | 2004 | Pro Natl Acad Sci USA2004，101，： | 1 |
| 17 | Coherent supercontinuum generation in photonic crystal fiber with all- normal group velocity dispersion显示文摘 | Hooper L E Mosley P J Muir A C | 2011 | Optics Express2011，19，6： | 1 |
| 18 | Microbial biohydrogenation of oleic acid to trans isomers in vitro 显示文摘 | E E Mosley G L Powell M B Riley | 2002 | Lipid Research2002，43，： | 1 |
| 19 | Microbial biohydrogenation of oleic acid to trans isomers in vitro显示文摘 | Mosley E E Powell G L Riley M B | 2002 | Journal of Lipid Research2002，43，： | 1 |
| 20 | The effects of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | ELDREDGE E P HOLMES Z A MOSLEY A R | 1996 | Am Potato J1996，73，： | 1 |
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