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| 1 | Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution显示文摘AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1 solution supplemented with or without IGF-1 and then perfused 'ex vivo ' for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.RESULTS: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.CONCLUSION: IGL-1 enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion. | Mohamed Amine Zaouali Susagna Padrissa-Altés Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 2 | Influence of deposition temperature on structural, optical and electrical properties of sputtered A1 doped ZnO thin films 显示文摘 | Mosbah A Aida M S | 2012 | J Alloy Compd2012，515，： | 1 |
| 3 | TSP1 and MMP9 genetic variants in sporadic prostate cancer显示文摘 | Sfar S Saad H Mosbah F Gabbouj S Chouchane L | 2007 | Cancer Genet Cytogenet2007，172，： | 1 |
| 4 | Preparation of Higly Textured Surface ZnO Thin Films显示文摘 | Mosbah A Abed S Bouhssira N | 2006 | Materials Science and Engineering B:Solid-State Materials for Advanced Technology2006，129，13： | 1 |
| 5 | Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggres- siveness显示文摘 | Sfar S Saad H Mosbah F | 2009 | Mol Biol Rep2009，36，1： | 1 |
| 6 | Experimental and numerical modeling of equiaxed solidification in metallic alloys 显示文摘 | GANDIN C A MOSBAH S VOLKMANN T HERLACH D M | 2008 | Acta Materialia2008，56，： | 1 |
| 7 | Trans-urethral bladder lithotripsy using the Lithoclast in children:Apropos of 7cases 显示文摘 | Mosbah A Krid M Baccouche S | 1995 | Prog Urol1995，5，1： | 1 |
| 8 | TSP1 and MMP9 genetic variants in sporadic prostate cancer 显示文摘 | SFAR S SAAD H MOSBAH F | 2007 | Cancer Genet Cytogenet2007，172，： | 1 |
| 9 | Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggressiveness显示文摘 | S#ar S Saad H Mosbah F | 2009 | Mol Biol Rep2009，36，： | 1 |
| 10 | Powder Compaction Modelling Via the Discrete and Finite Element Method显示文摘 | Ransingu R S Gethin D T Khoei A R P Mosbah R W Lewis | 2000 | Materials and Design2000，21，4： | 1 |
| 11 | Cobatoxin 1 from Centruroides noxius scorpion venom:chemical synthesis,three-dimensional structure in solution,pharmacology and docking on K+ channels显示文摘 | Jouirou B Mosbah A Visan V Grissmer S | 2004 | Biochem J2004，377，1： | 1 |
| 12 | Convex drawing of 3 - connected plane grsphs显示文摘 | BONICHON N FELSNER S MOSBAH M | 2007 | Algorithmica2007，47，4： | 1 |
| 13 | Diversity of folds in animal toxins acting on ion channels 显示文摘 | MOUHAT S JOUIROU B MOSBAH A | 2004 | Biochemical Journal2004，378，： | 1 |
| 14 | TSP1 and MMP9 genetic variants in sporadic prostate cancer显示文摘 | Sfar S Saad H Mosbah F | 2007 | Cancer Genet Cytogenet2007，172，1： | 1 |
| 15 | Biochemical and molecular characterization of a lipase produced by Rhizo- pus oryzae显示文摘 | S/~LAH R B MOSBAH H FENDRI A | 2006 | FEMS Mierobiol Lett2006，260，2： | 1 |
| 16 | Association of VEGF genetic polymorphisms with prostate carcinoma risk and clinical outcome显示文摘 | Sfar S Hassen E Saad H Mosbah F | | Cytokine0，35，12： | 1 |
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