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| 1 | Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology显示文摘BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is limited.Early recognition of metastases is important to avoid futile locoregional treatments.Furthermore,knowledge on metastatic patterns is necessary for further development of personalized treatment modalities.AIM To gain insight into the metastatic pattern of gastroesophageal cancer.METHODS A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was performed.Only patient with metastases were included for analysis.The metastatic pattern was analyzed according to the primary tumor location and histological subtype.RESULTS Metastatic disease was found in 268 esophageal and 331 gastric cancer patients.In esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal SCC.In gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric AC.CONCLUSION This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. | Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel Rosman Rachel S van der Post | 2020 | World Journal of Gastroenterology2020，26，39： | 9 |
| 2 | Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury显示文摘Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable condition.It is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic cavitation.Previously,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue integration.Here,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal cord.Immunohistochemistry demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host interface.Few reactive astroglial or regenerating axonal profiles could be seen traversing this layer.Such encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the implant.Characterization of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine. | Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook | 2019 | Regenerative Biomaterials2019，6，2： | 4 |
| 3 | Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention显示文摘 | Pascalle S Monraats Yue Fang Douwe Pons Nuno MM Pires Huibert AP Pols Aeilko H Zwinderman Moniek PM de Maat Pieter AF Doevendans Robbert J deWinter René A Tio Johannes Waltenberger Rune R Frants Paul HA Quax Arnoud van der Laarse Ernst E van der Wall Andr | 2010 | Expert Opinion on Therapeutic Targets2010，，： | 1 |
| 4 | Transition to Ecological Urban Agriculture; a Challenge显示文摘 | Moniek van Hirtum Eric Goewie Yilma Getachew & Pene van Veenhuizen | 2002 | Urban Agriculture Magazine2002，，6： | 1 |
| 5 | Relationship between CRP and clinical course of unstable angina depends on assay method显示文摘 | MONIEK P M FRITS H C K | 2002 | Vascul Pharma2002，39，3： | 1 |
| 6 | Remodeling of the cardiac sodium channel, connexin 43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy显示文摘 | Maartje Noorman Sara Hakim Elise Kessler Judith Groeneweg Moniek G.P.J. Cox Angeliki Asimaki Harold V.M. van Rijen Leonie van Stuijvenberg Halina Chkourko Marcel A.G. van der Heyden Marc A. Vos Nicolaas de Jonge Jasper J. van der Smagt Dennis Dooijes Arya | 2013 | Heart Rhythm2013，，： | 1 |
| 7 | Association of Novel Genetic Loci With Circulating Fibrinogen Levels: A Genome-Wide Association Study in 6 Population-Based Cohorts显示文摘 | Abbas Dehghan Qiong Yang Annette Peters Saonli Basu Joshua C. Bis Alicja R. Rudnicka Maryam Kavousi Ming-Huei Chen Jens Baumert Gordon D.O. Lowe Barbara McKnight Weihong Tang Moniek de Maat Martin G. Larson Susana Eyhermendy Wendy L. McArdle Thomas Lumley | 2009 | Circulation: Cardiovascular Genetics2009，，2： | 1 |
| 8 | Early Detection of Regional Functional Abnormalities in Asymptomatic ARVD/C Gene Carriers显示文摘 | Arco J. Teske Moniek G.P.J. Cox Anneline S.J.M. te Riele Bart W. De Boeck Pieter A. Doevendans Richard N.W. Hauer Maarten J.M. Cramer | 2012 | Journal of the American Society of Echocardiography2012，，9： | 1 |
| 9 | C-Reactive Protein Predicts Progression of Atherosclerosis Measured at Various Sites in the Arterial Tree: The Rotterdam Study显示文摘 | Irene M. van der Meer Moniek P.M. de Maat A. Elisabeth Hak Amanda J. Kiliaan Antonio Iglesias del Sol Deirdre A.M. van der Kuip Rogier L.G. Nijhuis Albert Hofman Jacqueline C.M. Witteman | 2002 | Stroke: Journal of the American Heart Association2002，，12： | 1 |
| 10 | C- reactive protein in atherosclerosis:A causal factor? 显示文摘 | Elaine P Moniek PM | 2006 | cardiovascular Research2006，71，1： | 1 |
| 11 | Distinguishing Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia–Associated Mutations From Background Genetic Noise显示文摘 | Jamie D. Kapplinger Andrew P. Landstrom Benjamin A. Salisbury Thomas E. Callis Guido D. Pollevick David J. Tester Moniek G.P.J. Cox Zahir Bhuiyan Hennie Bikker Ans C.P. Wiesfeld Richard N.W. Hauer J. Peter van Tintelen Jan D.H. Jongbloed Hugh Calkins Dani | 2011 | Journal of the American College of Cardiology2011，，23： | 1 |
| 12 | Activation Delay and VT Parameters in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Toward Improvement of Diagnostic ECG Criteria显示文摘 | MONIEK G.P.J.COX MARCEL R.NELEN ARTHUR A.M.WILDE ANS C.WIESFELD JASPER JvdSMAGT PETERLOH MAARTEN J.CRAMER PIETER A.DOEVENDANS J. PETER vTINTELEN JACQUES M.T.De BAKKER RICHARD N.W.HAUER | 2008 | Journal of Cardiovascular Electrophysiology2008，，8： | 1 |
| 13 | Prognostic markers in young patients with premature coronary heart disease显示文摘 | Janine E. van Loon Moniek P.M. de Maat Jaap W. Deckers Ron T. van Domburg Frank W.G. Leebeek | 2012 | Atherosclerosis2012，，1： | 1 |
| 14 | Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Pathogenic Desmosome Mutations in Index-Patients Predict Outcome of Family Screening: Dutch Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Genotype-Phenotype Follow-Up Study显示文摘 | Moniek G.P.J. Cox Paul A. van der Zwaag Christian van der Werf Jasper J. van der Smagt Maartje Noorman Zahir A. Bhuiyan Ans C.P. Wiesfeld Paul G.A. Volders Irene M. van Langen Douwe E. Atsma Dennis Dooijes Arthur van den Wijngaard Arjan C. Houweling Jan D | 2011 | Circulation2011，，23： | 1 |
| 15 | Prognostic markers in young patients with premature coronary heart disease显示文摘 | Janine E. van Loon Moniek P.M. de Maat Jaap W. Deckers Ron T. van Domburg Frank W.G. Leebeek | 2012 | Atherosclerosis2012，，1： | 1 |
| 16 | Nucleos(t)ide Analogues Only Induce Temporary Hepatitis B e Antigen Seroconversion in Most Patients With Chronic Hepatitis B显示文摘 | Jurri?n G.P. Reijnders Moniek J. Perquin Ningping Zhang Bettina E. Hansen Harry L.A. Janssen | 2010 | Gastroenterology2010，，2： | 1 |
| 17 | Both Erk and p38 kinases are necessary for eytokine gene transcription 显示文摘 | Carter A B Moniek M M Hunninghake G W | 1999 | Am J Respir Cell Mol Biol1999，20，4： | 1 |
| 18 | C-reactive protein in atherosclerosis:A causal factor?显示文摘 | Paffen E Moniek PM | 2006 | Cardiovascular Research2006，71，： | 1 |
| 19 | C-reactive protein in atherosclero8is: A causal factor 显示文摘 | Elaine P Moniek PM | 2006 | cardiov cular Research2006，71，1： | 1 |
| 20 | C-reactive protein in atherosclerosis:A causal factor?显示文摘 | Elaine P Moniek PM | 2006 | cardiovascular Research2006，71，1： | 1 |
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