|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand axis in nonalcoholic fatty liver disease显示文摘Concomitantly with the increase in the prevalences of overweight/obesity, nonalcoholic fatty liver disease(NAFLD) has worldwide become the main cause of chronic liver disease in both adults and children. Patients with fatty liver display features of metabolic syndrome(Met S), like insulin resistance(IR), glucose intolerance, hypertension and dyslipidemia. Recently, epidemiological studies have linked obesity, Met S, and NAFLD to decreased bone mineral density and osteoporosis, highlighting an intricate interplay among bone, adipose tissue, and liver. Osteoprotegerin(OPG), an important symbol of the receptor activator of nuclear factor-B ligand/receptor activator of nuclear factor kappa B/OPG system activation, typically considered for its role in bone metabolism, may also play critical roles in the initiation and perpetuation of obesityrelated comorbidities. Clinical data have indicated that OPG concentrations are associated with hypertension, left ventricular hypertrophy, vascular calcification, endothelial dysfunction, and severity of liver damage in chronic hepatitis C. Nonetheless, the relationship between circulating OPG and IR as a key feature of Met S as well as between OPG and NAFLD remains uncertain. Thus, the aims of the present review are to provide the existent knowledge on these associations and to discuss briefly the underlying mechanisms linking OPG and NAFLD. | Lucia Pacifico Gian Marco Andreoli Miriam D'Avanzo Delia De Mitri Pasquale Pierimarchi | 2018 | World Journal of Gastroenterology2018，24，19： | 11 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Immunogenicity of hepatitis B vaccine among hemodialysis patients: Effect of revaccination of non-responders and duration of protection显示文摘 | Sandra S. Chaves Danni Daniels Brian W. Cooper Susan Malo-Schlegel Susan MacArthur Karen C. Robbins John F. Kobetitsch Aimee McDaniel John F. D’Avella Miriam J. Alter | 2011 | Vaccine2011，，52： | 2 |
| 4 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A AlMazroa Miriam Alvara | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 5 | Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis显示文摘 | Simon IR Noble Mike D Shelley Bernadette Coles Susan M Williams Andrew Wilcock Miriam J Johnson | 2008 | Lancet Oncology2008，，6： | 2 |
| 6 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 7 | Assessment of lead, cadmium, and zinc contamination of roadside soils, surface films, and vegetables in Kampala City, Uganda 显示文摘 | Grace N Hannington O Miriam D | 2006 | Environmental Research2006，101，1： | 1 |
| 8 | Effects of agro- chemical treatments on the occurrence of Fusariurn ear rot andfumonisin contamination of maize in Southern Italy 显示文摘 | Filippo D C Vincenzo D C Miriam H | 2011 | Field Crops Research2011，123，2： | 1 |
| 9 | Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy eows显示文摘 | Miriam L K Julie R B Debra A D | 1998 | Journal of Nutrition1998，128，： | 1 |
| 10 | Validation of the 'International Consultation on Incontinence Questionnaire-Short Form' (ICIQ-SF) for Portuguese显示文摘 | Jose Tadeu Nunes Tamanini Miriam Dambros Carlos Arturo Levi D'Ancona | 2004 | Rev Saude Publica2004，38，3： | 1 |
| 11 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A AlMazroa Miriam Alvara | 2012 | The Lancet2012，，9859： | 1 |
| 12 | Assessment of lead, cadmium, and zinc contamination of roadside soils, surface films and vegetables in Kampala City, Uganda显示文摘 | Grace N Hannington O O Miriam D | 2006 | Environmental Research2006，101，1： | 1 |
| 13 | Assessment of Lead, Cadmium, and Zinc Contamination of Roadside Soils, Surface Films, and Vegetables in Kampala City, Uganda 显示文摘 | GRACE N HANNINGTON O O MIRIAM D | 2006 | Environmental Research2006，，101： | 1 |
| 14 | Influence of emulsion composition and inlet air temperature on the microencapsulation of flaxseed oil by spray drying显示文摘 | Renata V Tonon Carlos R F Grosso Miriam D Hubinger | | 0，，01： | 1 |
| 15 | Expression of adiponectin receptors in pancreatic β cells显示文摘 | Ilham Kharroubi Joanne Rasschaert Décio L Eizirik Miriam Cnop | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
| 16 | Extraction and Clean-up Preocedure for Analysis of Organochlorine Pesticide Residues in Ethoxylated Lanolin显示文摘 | LUCIANA P MIRIAM S ANA P d O S | 2000 | J II Farmaco2000，55，： | 1 |
| 17 | Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows 显示文摘 | Miriam L K Julie R B Debra A D | 1998 | Journal of Nutrition1998，128，： | 1 |
| 18 | Calciumantagonists and converting enzyme inhibitors reduce renal injury by different mechanisms显示文摘 | Dworkin L D Bensten J A Miriam Parker | 1993 | Kidney Int1993，43，4： | 1 |
| 19 | Influence of emulsion composition and inlet air temperature on the microencapsulation of flaxseed oil by spray drying 显示文摘 | Renata V Tonon Carlos R F Grosso Miriam D Hubinger | 2011 | Food Research International2011，，1： | 1 |
| 20 | Ice Ⅵ freezing of meat:supercooling and ultrastruetural studies显示文摘 | ANTONIO D M LAURA O MIRIAM N M | 2004 | Meat Science2004，66，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员