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| 1 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 2 | Important source of marine secondary organic aerosol from biogenic amines 显示文摘 | Facchini M C Decesari S Rinaldi M Carbone C Finessi E Mircea M Fuzzi S Moretti F Tagliavini E Ceburnis D O'Dowd C D | 2008 | Environ Sci Technol2008，42，24： | 1 |
| 3 | Unbalanced magnetic pull due to asymmetry and low-level static rotor eccentricity in fractional-slot brushless permanent-magnet motors with surface-magnet and consequent-pole rotors显示文摘 | DAVID G D MIRCEA P DAN M I | | 0，，07： | 1 |
| 4 | Long and fast Up/Down counters 显示文摘 | Mircea R Stan Alexandre F Tenca Milos D Ercegovac | 1998 | IEEE Trans on Computers1998，47，7： | 1 |
| 5 | Analytical and numerical stu dy on the maximum force developed by a V-beam thermal actuator显示文摘 | Radu S C Mircea C D Marius P | 2014 | Procedia Technology2014，12，： | 1 |
| 6 | Adjuvant chemotherapy for radically resected non-small cell lung cancer:A retrospective analysis of 311 consectively treated patients显示文摘 | Teodor H Alin T | 2005 | Lung Cancer2005，47，1： | 1 |
| 7 | Long-termDurability of Reinforced and Prestressed Elements inAggressive Environments显示文摘 | MIRCEA D IOANI A FILIP M | 1994 | ACI Materials Journal1994，91，2： | 1 |
| 8 | Reliability-based design for transmission line structure foundations 显示文摘 | Phoon Kok-Kwang Kulhawy Fred H Grigoriu Mircea D | 2000 | Computers and Geoteehnics2000，26，34： | 1 |
| 9 | Development of a reliability-based design framework for transmission line structure foundations 显示文摘 | Phoon Kok-Kwang Kulhawy Fred H Grigoriu Mircea D | 2003 | Journal of Geotechnieal and Geoenvironmental Engineering2003，129，9： | 1 |
| 10 | Multiple resistance factor design for shallow transmis- sion line structure foundations 显示文摘 | Phoon Kok-Kwang Kulhawy Fred H Crrigoriu Mircea D | 2003 | Journal of Geoteehni- eal and Geoenvironmental Engineering2003，129，9： | 1 |
| 11 | Carbonic anhydrase activators: design of high affinity isozymes I , II , and IV activators, incorporating tri-/tetrasubstituted-pyridinium azole moieties显示文摘 | Monica I Mircea D B Marc A I | 2002 | J Med Chem2002，45，2： | 1 |
| 12 | Phase 2 HERALD study of patritumab(P)with erlotinib(E)in advanced NSCLC subjects(SBJs)显示文摘 | Joachim Von P Jennifer T Mircea D | 2014 | J Clin Oncol(Meeting Abstracts)2014，32，15： | 1 |
| 13 | Load carrying capacity of a heterogeneous surface bearing显示文摘It has been shown before that liquids can slip at a solid boundary,which prompted the idea that parallel-surfaces bearings can be achieved just by alternating slip and non-slip regions in the direction of fluid flow.The amount of slip at the wall depends on the surface tension at the liquid-solid interface,which in turn depends on the chemical state of the surface and its roughness.In the present study a heterogeneous surface was obtained by coating half of a circular glass disc with a coating repellant to glycerol.A rotating glass disc was placed at a known/calibrated distance and the gap was filled with glycerol.With the mobile surface moving from the direction of slip to non-slip region it can be theoretically shown that a pressure build up can be achieved.The pressure gradient in the two regions is constant,similar to that in a Rayleigh step bearing,with the maximum pressure at the separation line.The heterogeneous disc was placed on a holder supported by a load cell thus the force generated by this pressure increase can be measured accurately.Tests were carried out at different sliding speeds and gaps and the load carried was measured and subsequently compared with theoretical calculations.This allowed the slip coefficient to be evaluated. | Evan THOMAS Mircea D PASCOVICI Romeo P GLOVNEA | 2015 | Friction2015，3，4： | 1 |
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