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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | A Selective Approach to the Resection of Cystic Lesions of the Pancreas显示文摘 | Peter JA Michael D Mithat G | 2006 | Ann Surg2006，244，4： | 1 |
| 3 | The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a celldeath pathway characterized by cleavage of Bid and production of reactive oxygen species显示文摘 | Astrid AR Michael JA David | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 4 | Randomized clinical trial comparing surgery with conservative treatment for uncomplicated varicose veins显示文摘 | MICHAELS JA BRAZIER JE CAMPBELL WB | 2006 | Br J Surg2006，93，2： | 1 |
| 5 | Posterior cruciate ligament retaining totalknee arthroplasty in patients with rheumatoid arthritis显示文摘 | Michael JA Richard AB Regina M | 2001 | J Bone Joint Surg2001，83，： | 1 |
| 6 | Serum and urine markers of bone metabolism during the year after hip fracture 显示文摘 | Yu -Yahiro JA Michael RH Dubin NH | 2001 | J Am Geriatr Soc2001，49，： | 1 |
| 7 | Effects of intravenous nesiritide on human coronary vasomotor regulation and myocardial oxygen uptake显示文摘 | Michaels AD Klein A Madden JA | 2003 | Criculation2003，107，： | 1 |
| 8 | Effects of intravenous nesiritide nn htlman eoronaD, vasonlolor regulation and myoearditl oxygen up take显示文摘 | Michaels AD Klein A Madden JA | 2003 | Circulation2003，107，21： | 1 |
| 9 | Effects of intravenousnesirit- ide on human coronary regulation and myocardial oxygen up take显示文摘 | Michaels AD Klein A Madden JA | 2008 | Circulation2008，107，2： | 1 |
| 10 | Effects of intravenous nesiritide on human coronary vasomotor regulation and myocardial oxygen uptake显示文摘 | Michaels AD Klein A Madden JA | 2003 | Circulation2003，107，： | 1 |
| 11 | Effects of intravenous nesiritide on human coronary vasomotor regulation and myocardial oxygen uptake显示文摘 | Michaels AD Klein A Madden JA | 2003 | Circulation2003，107，21： | 1 |
| 12 | What is new in adult reconstructive knee surgery 显示文摘 | Michael JA Richard EW | 2006 | J Bone Joint Surg Am2006，88，7： | 1 |
| 13 | Effects of intravenous nesiritide on human coronary vasomotor regulation and myocardial oxygen uptake显示文摘 | Michaels AD Andrew K Madden JA | 2003 | Circulation2003，107，21： | 1 |
| 14 | Effects of intravenous nesiritide on human coronary vasomotor regulation and myocardial oxygen uptake 显示文摘 | Michaels AD Klein A Madden JA | 2003 | Circulation2003，107，26： | 1 |
| 15 | Effects of intravenous nesirit-ide on human coronary vasomotor regulation and myocardial oxggen up-take显示文摘 | Michaels AD Andrew K Madden JA | 2003 | Circulation2003，107，21： | 1 |
| 16 | An uncommon cause of stroke in young adults显示文摘 | Bastiaan R Vincent TH | 1999 | Arch Neurol1999，56，： | 1 |
| 17 | Dressings for venous leg ulcers:systematic review and meta-analysis显示文摘 | Palfreyman S Nelson EA Michaels JA | 2007 | BMJ2007，335，7613： | 1 |
| 18 | Characterization of cerebral hemodynamic phases following severe head trauma:hypoperfusion,hyperemia,and vasospasm显示文摘 | Neil AM Ravish VP Michael JA | 1997 | J Neurosurg1997，87，： | 1 |
| 19 | Effects of intravenous nesiritide on human coronary vasomotor regulation and myocardial oxygen uptake显示文摘 | Michaels AD Klein A Madden JA | 2003 | Circulation2003，107，4： | 1 |
| 20 | Abfraction:separating fact from fiction显示文摘 | Michael JA Townsend GC Greewood LF | 2009 | Aust Dent J2009，54，1： | 1 |
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