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| 1 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 2 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 3 | Distal Pancreatectomy: Risk Factors for Surgical Failure in 302 Consecutive Cases显示文摘 | J?rg Kleeff Markus K. Diener Kaspar Z?graggen Ulf Hinz Markus Wagner Jeannine Bachmann J?rg Zehetner Michael W. Müller Helmut Friess Markus W. Büchler | 2007 | Annals of Surgery2007，，4： | 3 |
| 4 | Endothelial vasodilator production by ovine uterine and systemic arteries:ovarian steroid and pregnancy control of ERα and ER β levels显示文摘 | Michael J B Amy Z Terrance M | 2005 | The Journal of Physiology2005，565，： | 1 |
| 5 | Genetic diversity in five Iranian native chicken populations estimated by microsatellite markers 显示文摘 | Shahbazi S Seyed Z M and Michael N R | 2007 | Biochemical Genetics2007，，45： | 1 |
| 6 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z O' Connor S M van Holst Pellekaan N G | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 7 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z O'Connor S M van Hoist Pellekaan N G | 2003 | Mol Cancer Res2003，1，： | 1 |
| 8 | Survival factor-mediated Bad phosphorylation raises the mito-chondrial threshold for apoptsis显示文摘 | Sandeep Robert Datta Ann M Ranger Michael Z Lin | 2002 | Dev Cell2002，3，5： | 1 |
| 9 | Re- duced accumulation of specific microRNAs in colorectal 显示文摘 | Michael M Z O'Connor S M van Hoist Pellekaan N G | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 10 | Automatic reconstruction of personalized avatars显示文摘 | Michael Z Michael M Günther G | 2011 | Computer Animation Virtual Worlds2011，22，1： | 1 |
| 11 | Automated residue analysis of tetracyclines and their metabolites in whole egg,egg white,egg yolk and hen's plasma utilizing a modified ASTED system显示文摘 | GEORG Z ERIKA M S MICHAEL | 2000 | Journal of Chromatography B:Biomedical Sciences and Applications2000，739，： | 1 |
| 12 | Renal Fibrosis: Extracellu- lar Matrix Mi t Regulates Migratory Behavior of Acti- vated Tubular Epithelial Cells 显示文摘 | Michael Z Yohei M Barbara M | 2002 | Am J Pathol2002，160，6： | 1 |
| 13 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z O′ C S van Holst P N | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 14 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | MICHAEL M Z O' CONNOR S M VAN-HOLST-PELLEKAAN N G | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 15 | Reduced accumulation of specific microRNAs in colorectal neoplasia 显示文摘 | MICHAEL M Z | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 16 | FGF23 induces left ventricular hypertrophy显示文摘 | Faul Christian Amaral Ansel P Oskouei Behzad Hu Ming-Chang Sloan Alexis Isakova Tamara Gutiérrez Orlando M Aguillon-Prada Robier Lincoln Joy Hare Joshua M Mundel Peter Morales Azorides Scialla Julia Fischer Michael Soliman Elsayed Z Chen J | 2011 | Journal of Clinical Investigation2011，，11： | 1 |
| 17 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z SM O C van Holst Pel ekaan N G | | 0，，12： | 1 |
| 18 | Reduced accumulation of specific microRNAs in colorectal neoplasia 显示文摘 | Michael Z M O' Connor S M van Hoist Pellekaan N G | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 19 | Stability of networked control systems显示文摘 | Michael S B Philips S M | 2001 | IEEE Control Systems Magazine2001，21，2： | 1 |
| 20 | Marketing R&D marketing integration in the new product devel- opment process 显示文摘 | MICHAEL S SABRINA M N YUZHEN Z | 1996 | Industrial Marketing Management1996，，25： | 1 |
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