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| 1 | Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy显示文摘Although the aetiology of inflammatory bowel disease (IBD) remains unknown, the pathogenesis is gradually being unravelled, seeming to be the result of a combination of environmental, genetic, and immunological factors in which an uncontrolled immune response within the intestinal lumen leads to inflammation in genetically predisposed individuals. Multifactorial evidence suggests that a defect of innate immune response to microbial agents is involved in IBD. This editorial outlines the immunopathogenesis of IBD and their current and future therapy. We present IBD as a result of dysregulated mucosal response in the intestinal wall facilitated by defects in epithelial barrier function and the mucosal immune system with excessive production of cytokines growth factors, adhesion molecules, and reactive oxygen metabolites, resulting in tissue injury. Established and evolving therapies are discussed in the second part of this editorial and at the end of this section we review new therapies to modulate the immune system in patients with IBD. | MI Torres A Ríos | 2008 | World Journal of Gastroenterology2008，14，13： | 18 |
| 2 | New aspects in celiac disease显示文摘Celiac disease (CD) is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA- DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance (oral tolerance) to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis. | MI Torres MA López Casado A Ríos | 2007 | World Journal of Gastroenterology2007，13，8： | 10 |
| 3 | Organizing,educating,and advocating for health and human rights in vieques,Puerto rico显示文摘 | Torres MI | 2005 | Am J Public Health2005，95，1： | 1 |
| 4 | Experimental colitis induced by trinitrobenzene sulfonic acid: an ultrastructural and histochemical study显示文摘 | TORRES MI FERNANDEZ MI NIETO N | 1999 | Dig Dis Sci1999，44，12： | 1 |
| 5 | Ran- domized clinical trial: nasoenteric tube or jejunostomy as a route for nutrition after major upper gastrointestinal operations 显示文摘 | Torres Jrnior LG de Vasconcellos Santos FA Correia MI | 2014 | World J Surg2014，38，9： | 1 |
| 6 | A new approachusing tissue alkaline phosphatase histochemistry to identifyCrohn′s disease显示文摘 | Torres MI Lorite P Lpez-Casado MA | 2007 | Pathol Res Pract2007，203，6： | 1 |
| 7 | Potential role of the IL-33/ST2 axis in celiac disease显示文摘IL-33/ST2 轴在几织物特定的自体免疫的疾病的致病被含有。腹的疾病(CD ) 是主要基因因素(HLA-DQ2/DQ8 ) 和为危险性的 etiologic (饮食的面筋) 在被知道的唯一的自体免疫的疾病。我们测量了浆液层次和 IL-33 和它的受体的坚定的肠的织物表示在病人与的可溶的 ST2 与疾病活动调查他们的协会的 CD。没有 CD, IL-33 和 sST2 的浆液和织物层次与在控制病人的那些相比在有 CD 的病人是显著地更高的。我们证明显著地从大麦和小麦麦胶蛋白质提取的有毒的肽从腹的病人在有教养的外部血 mononuclear 房间刺激 IL-33 和 ST2 的生产,强烈含有在 CD 的致病的 IL-33/ST2 轴。在织物和浆液的 IL-33 和它的受体 ST2 的高水平反映一个活跃煽动性的状态并且可以为疾病活动代表潜在的 biomarker。IL-33/ST2 版本,行动的模式,和规定的更好的理解将是关键的开发治疗学指向 IL-33/ST2 小径到对待 CD。 | Lopez-Casado MA Lorite P Palomeque T Torres MI | 2017 | Cellular & Molecular Immunology2017，14，3： | 1 |
| 8 | Does opening a milk bank in a neonatal unit change infant feeding practices? A before and after study显示文摘 | Utrera Torres MI Medina López C Vázquez Román S | 2010 | IntBreastfeed2010，8，5： | 1 |
| 9 | Effect of material properties on long-term deflections of GFRP reinforced concrete beams显示文摘 | MIàS C TORRES L TURON A | 2013 | Construction and Building Materials2013，41，4： | 1 |
| 10 | Experimental study of immediate and time-dependent deflections of GFRP reinforced concrete beams显示文摘 | MIàS C TORRES L TURON A | 2013 | Composite Structures2013，96，2： | 1 |
| 11 | Dietary nucleotides modulate mitochondfial function of intestinal mucosa in weanling rats with chronic diarrhea 显示文摘 | Arnaud A Lopez-Pedrosa JM Torres MI | 2003 | J Pediatr Gastroenterol Nutr2003，37，2： | 1 |
| 12 | Soluble HLA-G in heart transplantation: their relationship to rejection episodes and immunosuppressive therapy 显示文摘 | Luque J Torres MI Aumente MD | 2006 | Hum lmmunol2006，67，： | 1 |
| 13 | Soluble HLA-G in heart transplantation: their relationship to rejection episodes and immunosuppressive therapy 显示文摘 | Luque J Torres MI Aumente MD | 2006 | Hum Immunol2006，67，45： | 1 |
| 14 | High- resolution computed tomography patterns of organizing pneumonia 显示文摘 | Bravo Sober6n A Torres Snchez MI Garcla Rio F | 2006 | Arch Brenconeumol2006，42，8： | 1 |
| 15 | Experimental ulcerative colitis impairs antioxidant defense system in rat intestine 显示文摘 | Nieto N Torres MI Fernandez MI | 2000 | Dig Dis Sci2000，45，： | 1 |
| 16 | Dietary nucleotides modulate mitochondrial function of intestinal mucosa in weanling rats with chronic diarrhea显示文摘 | Amaud A Lopez Pedrosa JM Torres MI | 2003 | Journal of Pediatric Gastroenterology and Nutrition2003，2，37： | 1 |
| 17 | Experimental ulcerative colitis impairs antioxidant defense system in rat intestine显示文摘 | Nieto N Torres MI Fernandez MI | 2000 | Dig Dis Sci2000，45，9： | 1 |
| 18 | Dietary nucleotides modulate mitochondrial function of intestinal mucosa in weanling rats with chronic diarrhea显示文摘 | Arnaud A López-Pedrosa JM Torres MI | | 0，，02： | 1 |
| 19 | Myofibroblatic inflammatory tumor of the lung显示文摘 | Pinilla I Herrero Y Torres MI | 2007 | Radiologa2007，49，1： | 1 |
| 20 | Oral findings and dental treatment in a child with williams-beuren syndrome显示文摘 | Torres CP Valadares G Martins MI | 2015 | Braz Dent J2015，26，3： | 1 |
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