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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘 | Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow | 2012 | The Lancet . 2012 (9850)2012，，9850： | 1 |
| 3 | Persistent activation of coagulation mechanism in unstable angina and myocardial infarction显示文摘 | Merlini P A Bauer K A Oltrona L | 1994 | Circulation1994，90，1： | 1 |
| 4 | Different quantitative apoptotic traits in coronary atherosclerotic plaques from patients with stable angi- na pectoris and acute coronary syndromes 显示文摘 | ROSSI M L MARZILIANO N MERLINI P A | 2004 | Circu- lation2004，110，： | 1 |
| 5 | Structure,conformational analysis and absolute configuration of the PerylenequinonePigments Elsinochromes B1,B2,C1 and C2显示文摘 | Arnone A Merlini L Mondelli R | 1993 | Gazzetta Chimica Italiana1993，123，3： | 1 |
| 6 | Noninflammatory fallopian tube pathology in children显示文摘 | Merlini L Anooshiravani M Vunda A | 2008 | Pediatr Radiol2008，38，12： | 1 |
| 7 | Vascular p-amy-loid and early astrocyte alterations impair cerebrovascular function andcerebral metobolism in transgenic arcA(3 mice 显示文摘 | Merlini M Meyer EP Ulmann-Schuler A | 2011 | Acta Neuropathol2011，122，3： | 1 |
| 8 | Amyloid-osis:pathogenesis and new therapeutic options显示文摘 | MERLINI G SELDIN D C GERTZ M A | 2011 | JClin Oncol2011，29，： | 1 |
| 9 | Clinical indications for plasma protein assays:transthyretin (prealbumin)in inflammation and malnutrition 显示文摘 | MYRON JOHNSON A MERLINI G SHELDON J | 2007 | Clin Chem Lab Med2007，45，3： | 1 |
| 10 | Flavonoids from Adenanthera pavonina显示文摘 | Gennaro A Merlini L Nasini G | 1972 | Phytochemistry1972，11，10： | 1 |
| 11 | International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders显示文摘 | Dispenzieri A Kyle R Merlini G | 2009 | Leukemia2009，23，2： | 1 |
| 12 | International Myeloma Working Group guidelines for serum free light chain analysis in multiple myeloma and related disordes 显示文摘 | Dispenzieri A Kyle R Merlini G | 2009 | Leukemia2009，23，2： | 1 |
| 13 | The structure of funicone, a new metabolite fromPenicillium funiculosum Thom 显示文摘 | Merlini L Nasini G Selva A | 1970 | Tetrahedron1970，26，： | 1 |
| 14 | Thrombocytopenia causedby abciximab or tirofiban and its association with clinical outcomein patients undergoing coronary stenting 显示文摘 | Merlini PA Rossi M Menozzi A | 2004 | Circulation2004，109，18： | 1 |
| 15 | C-reactive protein elevation and early outome in patients with unstable angina pectoris显示文摘 | Oltrona L Ardissino D Merlini P A | 1997 | Am J Cardiol1997，80，8： | 1 |
| 16 | Structures of the red sandalwood pigments,santalins A and B显示文摘 | Arnone A Camarda L Merlini L | 1975 | J Chem Soc Perkin Trans 11975，，2： | 1 |
| 17 | Sirolimus-eluting vs uncoated stents for prevention of restenosis in small coronary arteries: a randomized trial显示文摘 | Ardissino D Cavallini C Bramucci E Indolfi C Marzocchi A Manari A Angeloni G Carosio G Bonizzoni E Colusso S Repetto M Merlini PA SES-SMART Investigators | 2004 | JAMA2004，292，22： | 1 |
| 18 | Persistent activation of co?agulation mechanism in unstable angina and myocardial infarction 显示文摘 | Merlini P A Bauer KA Oltrona L | 1994 | Circulation1994，90，： | 1 |
| 19 | Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen V/ myopathies显示文摘 | Merlini L Angelin A Tiepolo T | 2008 | Proc Natl Acad Sci U S A2008，105，13： | 1 |
| 20 | C-reactive protein elevation and early outcome in patients with unstable angina pectoris 显示文摘 | Oltrona L Ardissino D Merlini P A | 1997 | Am J Cardiol1997，80，： | 1 |
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