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| 1 | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease显示文摘Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. | Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre | 2019 | Neural Regeneration Research2019，14，9： | 19 |
| 2 | Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association显示文摘 | Véronique L. Roger Alan S. Go Donald M. Lloyd-Jones Robert J. Adams Jarett D. Berry Todd M. Brown Mercedes R. Carnethon Shifan Dai Giovanni de Simone Earl S. Ford Caroline S. Fox Heather J. Fullerton Cathleen Gillespie Kurt J. Greenlund Susan M. Hailpern | 2011 | Circulation2011，，4： | 4 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | 羟基蛋氨酸螯合锰在肉仔鸡日粮中的应用效果显示文摘选用270只‘爱拔益加’(AA)雄性肉仔鸡,随机分成5组,每组设9个重复,每个重复6只鸡,分别饲喂玉米-豆粕基础日粮、60mg/kg硫酸锰日粮、基础日粮分别添加30、60、90mg/kg羟基蛋氨酸螯合锰日粮(试验组),试验期分为前期(0~3周)和后期(4~6周),研究了不同剂量羟基蛋氨酸鳌合锰对0~6周龄肉仔鸡生长性能、免疫力以及抗氧化能力的影响.结果表明:基础日粮中添加有机锰能够提高肉仔鸡饲料利用率,增强机体免疫力和抗氧化能力;日粮中有机锰水平与饲料利用率、胫骨锰含量、腹腔巨噬细胞吞噬指数和肝脏Mn-SOD酶活性呈一次线性关系,与新城疫抗体滴度呈二次曲线关系. | 马娅娅 Bun Sidoeun 刘丹 呙于明 曹宏 郭福存 郝正里 年芳 Mercedes V A | 2011 | 甘肃农业大学学报2011，46，4： | 2 |
| 5 | Risk factors of postictal generalized EEG suppression in generalized convulsive seizures显示文摘 | Alexandre V Mercedes B Valton L | 2015 | Neurology2015，85，18： | 1 |
| 6 | Determination of nickel, chromium and cobalt in wheat flour using slurry sampling electrothermal atomic absorption spectrometry显示文摘 | Mar G Mercedes G Miguel V | 1999 | Talanta1999，48，： | 1 |
| 7 | Characterization of selected spanish table wine samples according to their biogenic amine content from liquid chromatographic determination 显示文摘 | ROBERTO R MERCEDES S V DOMINGO G | 2002 | J Agric Food Chem2002，50，16： | 1 |
| 8 | Integrated biodiesel production: A comparison of different homogeneous catalysts systems 显示文摘 | Gemma V Mercedes M Jose A | 2004 | BioresourceTechnology2004，92，3： | 1 |
| 9 | Optimization of brassica carinata oil methanolysis for biodiesel production 显示文摘 | GEMMA V MERCEDES M JOS A | 2005 | Journal of American Oil Chemists''Society2005，82，： | 1 |
| 10 | A novel application of three phase hollow fiber based liquid phase microextraction (HF-LPME) for the HPLC determination of two endocrine disrupting compounds (EDCs), n-octylphenol and n-nonylphenol, in environmental waters显示文摘 | MERCEDES V MARIA R RUT F | 2013 | Sci Total Environ2013，443，： | 1 |
| 11 | Optimization of brassica carinata oil methanolysis for biodiesel production显示文摘 | Gemma V Mercedes M Jos A | 2005 | Journal of American Oil Chemists'' Society2005，82，： | 1 |
| 12 | Integrated biodiesel production : A comparison of different homogeneous catalysts systems 显示文摘 | Gemma V Mercedes M Jose A | 2004 | Bioresource Technology2004，92，3： | 1 |
| 13 | The Bacillus subtilis 168 csn gene encodes a chitosanase with similar properties to a Streptomyces enzyme显示文摘 | Rivas L A Parro V Mercedes M P | 2000 | Microbiology2000，146，： | 1 |
| 14 | Integrated biodiesel production:A comparison of different homogeneous catalysts systems显示文摘 | Gemma V Mercedes M Jose A | 2004 | Bioresource Technology2004，92，3： | 1 |
| 15 | Optimization of integrated biodiescl production(Ⅰ):A study of the biodiesel purity and yield显示文摘 | GEMMA V MERCEDES M JOSE A | 2007 | Bioresource Technology2007，98，： | 1 |
| 16 | Singleshot plasmid DNA intrasplenic immunization for the production of monoclonal antibodies persistent expression of DNA显示文摘 | CARLOS A V JULIANA C MERCEDES S | 2000 | Journal of immunological methods2000，244，： | 1 |
| 17 | On the role of water in peroxidase catalysis:a theoretical investigation of HRP compound I formation显示文摘 | Pietro V Giacomo F Mercedes A P | 2010 | Journal of Physical Chemistry B2010，114，： | 1 |
| 18 | HuR/ Methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation and carcinogenesis 显示文摘 | MERCEDES V C DAVID F R NIVEVS E | 2010 | Gas- troenterology2010，138，5： | 1 |
| 19 | Exposure of maize seeds to stationary magnetic fields:Effects on germination and early growth 显示文摘 | Mercedes F Carbonell M V Martinez E | 2007 | Environmental and Experimental Botany2007，59，： | 1 |
| 20 | H2O2,but not menadione,provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae显示文摘 | Hugo O Elisabete C Mercedes D V | | 0，，： | 1 |
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