|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Seasonal variation in body mass and energy budget in Chinese bulbuls (pycnonotus sinensis)显示文摘Background: Seasonal adjustments in body mass and energy budget are important for the survival of small birds in temperate zones. Seasonal changes in body mass, body temperature, gross energy intake(GEI), digestible energy intake(DEI), body fat content, as well as length and mass of the digestive tract, were measured in Chinese Bulbuls(Pycnonotus sinensis) caught in the wild at Wenzhou, China.Methods: Body mass was determined with a Sartorius balance. The caloric contents of the dried food and feces were then determined using a oxygen bomb calorimeter. Total fat was extracted from the dried carcasses by ether extraction in a Soxhlet apparatus. The digestive tract of each bird was measured and weighed, and was then dried to a constant mass.Results: Body mass showed a significant seasonal variation and was higher in spring and winter than in summer and autumn. Body fat was higher in winter than in other seasons. GEI and DEI were significantly higher in winter.The length and mass of the digestive tract were greatest in winter and the magnitude of both these parameters was positively correlated with body mass, GEI and DEI. Small passerines typically have higher daily energy expenditure in winter, necessitating increased food consumption.Conclusions: This general observation is consistent with the observed winter increase in gut volume and body mass in Chinese Bulbuls. These results suggest that Chinese Bulbuls adjust to winter conditions by increasing their body mass, body fat, GEI, DEI and digestive tract size. | Mengsi Wu Yuchao Xiao Fang Yang Limeng Zhou Weihong Zheng Jinsong Liu | 2014 | Chinese Birds2014，，1： | 6 |
| 2 | Source-sink System and Sedimentary Model of Progradational Fan Delta Controlled by Restricted Ancient Gully:An Example in the Enping Formation in the Southern Baiyun Sag,Pearl River Mouth Basin,Northern South China Sea显示文摘Tectonic activity occurred during the depositional period of the Enping Formation in the southern Baiyun Sag in the Pearl River Mouth Basin,with a series of synsedimentary faults and a set of large fan delta reservoir bodies developing.There is no data from drilling,cores,etc.for this area,so this paper applies three-dimensional seismic data to study the structural style of the steep slope zone,the seismic facies characteristics of fan deltas,and the source-sink system and sedimentary model of the Enping Formation.The control action of tectonic activity on fan deltaic sedimentary systems is studied by combining interpretation of fault systems,dissection of structural styles,seismic reflection structure,seismic facies geometry,and seismic attribute analysis,together with theoretical analysis of the source-sink deposition process.The Baiyun Sag has experienced tectonic activity since the Eocene,and a series of synsedimentary faults are developed in the southern steep slope zone.Under the common control of multiple large synsedimentary faults,a large ancient gully formed in the steep slope zone in the south,which gradually widened from south to north.The uplift area in the southern part of the sag was exposed for a long time during the deposition of the Enping Formation and consequently suffered weathering and erosion.The resulting sediments were transported through a system of provenance channels composed of slopes and an ancient gully to the depression area,where they were deposited and eventually converged to form a large fan delta.The fan delta presents the overall characteristics of NS strong wedge reflection and EW strong domal reflection—thick in the middle part and thin in the wings.It displays a lobe-shaped distribution on the plane,with the fan root pointing to the south slope.According to differences in reflection intensity from bottom to top,it can be subdivided into three stages of progradational sedimentary bodies—the southern uplift and denudation zone,the large ancient gully,and the fan delta—which together constitute a complete source-sink system.This represents a sedimentary model of progradational fan delta under the overall joint control of the re stricted ancient gully and syndepositional faults. | FENG Congjun YAO Xingzong YANG Haizhang LI Daming SUN Mengsi | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 4 |
| 3 | Data-Driven Heuristic Assisted Memetic Algorithm for Efficient Inter-Satellite Link Scheduling in the BeiDou Navigation Satellite System显示文摘Inter-satellite link(ISL)scheduling is required by the BeiDou Navigation Satellite System(BDS)to guarantee the system ranging and communication performance.In the BDS,a great number of ISL scheduling instances must be addressed every day,which will certainly spend a lot of time via normal metaheuristics and hardly meet the quick-response requirements that often occur in real-world applications.To address the dual requirements of normal and quick-response ISL schedulings,a data-driven heuristic assisted memetic algorithm(DHMA)is proposed in this paper,which includes a high-performance memetic algorithm(MA)and a data-driven heuristic.In normal situations,the high-performance MA that hybridizes parallelism,competition,and evolution strategies is performed for high-quality ISL scheduling solutions over time.When in quick-response situations,the data-driven heuristic is performed to quickly schedule high-probability ISLs according to a prediction model,which is trained from the high-quality MA solutions.The main idea of the DHMA is to address normal and quick-response schedulings separately,while high-quality normal scheduling data are trained for quick-response use.In addition,this paper also presents an easy-to-understand ISL scheduling model and its NP-completeness.A seven-day experimental study with 10080 one-minute ISL scheduling instances shows the efficient performance of the DHMA in addressing the ISL scheduling in normal(in 84 hours)and quick-response(in 0.62 hour)situations,which can well meet the dual scheduling requirements in real-world BDS applications. | Yonghao Du Ling Wang Lining Xing Jungang Yan Mengsi Cai | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，11： | 4 |
| 4 | Mobility in China,2020:a tale of four phases显示文摘2020 was an unprecedented year;with rapid and drastic changes in human mobility due to the COVID-19 pandemic.To understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun),to the exceptional calm of COVID-19 lockdown,and then to the recovery period.We observed that cross-city movements;which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of cities.Following the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large cities.Mobility network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in China.While the mass migration back to large cities was delayed,smaller cities connected more densely to form new clusters.During the recovery period after travel restrictions were lifted,the netflows of over 55%city pairs reversed in direction compared to before the lockdown.These findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others. | Suoyi Tan Shengjie Lai Fan Fang Ziqiang Cao Bin Sai Bing Song Bitao Dai Shuhui Guo Chuchu Liu Mengsi Cai Tong Wang Mengning Wang Jiaxu Li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao Jing Tan Xin Sun Tao Zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu | 2021 | National Science Review2021，8，11： | 3 |
| 5 | Chemical vapor deposition growth of phase-selective inorganic lead halide perovskite films for sensitive photodetectors显示文摘Inorganic lead halide perovskites are attractive optoelectronic materials owing to their relative stability compared to organic cation alternatives.The chemical vapor deposition(CVD) method offers potential for high quality perovskite film growth.The deposition temperature is a critical parameter determining the film quality owing to the melting difference between the precursors.Here,perovskite films were deposited by the CVD method at various temperatures between 500-800℃.The perovskite phase converts from CsPb_(2)Br_(5) to CsPbBr_(3) gradually as the deposition temperature is increased.The grain size of the perovskite films also increases with temperature.The phase transition mechanism was clarified.The photoexcited state dynamics were investigated by spatially and temporally resolved fluorescence measurements.The perovskite film deposited under 750℃ condition is of the CsPbBr_(3) phase,showing low trap-state density and large crystalline grain size.A photodetector based on perovskite films shows high photocurrent and an on/off ratio of ~2.5×10^(4). | Weilong Xu Mengsi Niu Xiaoyu Yang Haiyue Chen Xiaohong Cai Trevor A.Smith Kenneth PGhiggino Xiaotao Hao | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 6 | Decomposition of factors influencing carbon emissions in the region of Beijing-Tianjin-Hebei,based on the perspective of terminal energy consumption显示文摘In order to analyze the factors influencing carbon emissions in the region of Beijing-Tianjin-Hebei and to explore the pathways to developing a low-carbon economy,this paper begins with the terminal energy consumption of three industries and residential consumption,and constructs an identical equation which is composed of population size,level of economic development,energy intensity,the proportion of energy consumption,energy structure,and the coefficient of carbon emissions.Based on the data of terminal energy consumption during 2000-2012,various factors are analyzed and their contribution is measured by Logarithmic Mean Divisia Index(LMDI).The results show that the levels of population and economy have a positive driving effect while energy intensity,energy structure,and carbon intensity have a negative driving effect;the proportion of energy consumption had a negative driving effect prior to 2006,then changed to positive.Among suggestions for a low-carbon economy are controlling population size,improving the quality of economic development,supporting research into new energy technology,accelerating regional integration and optimizing industrial structure,and enhancing environmental protection and spreading the concept of a low-carbon economy. | Xiaohong Yu Mengsi Zhang | 2014 | Chinese Journal of Population,Resources and Environment2014，12，4： | 2 |
| 7 | WHIRLY1 recruits the histone deacetylase HDA15 repressing leaf senescence and flowering in Arabidopsis显示文摘Leaf senescence is controlled by a complex regulatory network in which robustness is ensured by the activity of transcription factors and epigenetic regulators.However,how these coordinate the process of leaf senescence remains poorly understood.We found that WHIRLY1 interacts with Histone Deacetylase(HDA)15,a Reduced Potassium Dependence3(RPD3)/HDA1-type HDA,by using green fluorescent protein-nanotrap-mass spectrum assays.The development-dependent interaction between WHIRLY1 and HDA15 was further confirmed by bimolecular fluorescence complementation assays and co-immunoprecipitation assays in Arabidopsis.Multi-omics genome-wide transcriptome and H3K9 acetylome enrichment analysis showed that HDA15 delays leaf senescence and flowering by repressing the expression of the positive regulators of leaf senescence and flowering,such as LOX2 and LARP1 C,and reducing H3K9 ac levels at these loci;WHIRLY1 and HDA15 co-target to the region near the transcription start site of a subset of nutrient recycling-related genes(e.g.,Glutathione S-transferases 10,non-coding RNA,and photosystem II protein D1 synthesizer attenuator PDIL1-2),as well as WRKY53 and ELF4,and co-repress their expression by removing H3K9 acetylation.Our study revealed a key transcription regulatory node of nutrient recycling and senescence-associated genes involved in leaf senescence and flowering via the recruitment of HDA15 by the single-stranded DNA/RNA-binding protein WHIRLY1. | Dongmei Huang Wei Lan Weibo Ma Rulin Huang Wenfang Lin Mengsi Li Chia-Yang Chen Keqiang Wu Ying Miao | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 8 | A pH-regulated promoter for the ex-pression of recombinant proteins in Escherichia coli 显示文摘 | TOLENTINOGJ MENGSY BENNETT GN | 1992 | Biotechnol Lett1992，14，： | 1 |
| 9 | Preparation of electrically enhanced forward osmosis(FO)membrane by two-dimensional MXenes for organic fouling mitigation显示文摘In this work,a conductive thin film composite forward osmosis(TFC-FO)membrane was firstly prepared via vacuum filtering MXenes nanolayer on the outer surface of polyethersulfone membrane followed by interfacial polymerization in the other side.Moreover,its feasibility of mitigating organic fouling under electric field was evaluated.Results indicated that the addition of MXenes greatly reduced the electric resistance of membrane from 2.1×10^(12)Ωto 46.8Ω,enhanced the membrane porosity and promoted the membrane performance in terms of the ratio of water flux to reverse salt flux.The modified TFC-FO membrane presented the optimal performance with 0.47 g/m^(2)loading amount of MXenes.Organic fouling experiments using sodium alginate(SA)and bovine serum albumin(BSA)as representative demonstrated that the introduction of MXenes could effectively enhance the anti-fouling ability of TFC-FO membrane under the electric field of 2 V.The interelectron repulsion hindered organic foulants attaching into membrane surface and thus effectively alleviated the membrane fouling.More importantly,the modified TFC-FO membrane showed good stability during the fouling experiment of 10 h.In all,our work proved that introducing MXenes into the porous layer of support is feasible to alleviate organic fouling of FO membrane. | Mengsi Xu Pin Zhao Chuyang Y.Tang Xiawen Yi Xinhua Wang | 2022 | Chinese Chemical Letters2022，33，8： | 1 |
| 10 | Prognostic tumor microenvironment gene and the relationship with immune infiltration characteristics in metastatic breast cancer显示文摘The aim of this study was to reveal genes associated with breast cancer metastasis,to investigate their intrinsic relationship with immune cell infiltration in the tumor microenvironment,and to screen for prognostic biomarkers.Gene expression data of breast cancer patients and their metastases were downloaded from the GEO,TCGA database.R language package was used to screen for differentially expressed genes,enrichment analysis of genes,PPI network construction,and also to elucidate key genes for diagnostic and prognostic survival.Spearman’s r correlation was used to analyze the correlation between key genes and infiltrating immune cells.We screened 25 hub genes,FN1,CLEC5A,ATP8B4,TLR7,LY86,PTGER3 and other genes were differentially expressed in cancer and paraneoplastic tissues.However,patients with higher expression of CD1C,IL-18 breast cancer had a better prognosis in the 10 years survival period,while patients with high expression of FN1,EIF4EBP1 tumors had a worse prognosis.In addition,TP53 and HIF1 genes are closely related to the signaling pathway of breast cancer metastasis.In this study,gene expression of ATP8B4 and CD1C were correlated with cancer tissue infiltration of CD8^(+)T lymphocytes,while GSE43816,GSE62327 and TCGA databases showed that CD8^(+)T lymphocytes were closely associated with breast cancer progression.Functional enrichment analysis of genes based on expression differences yielded key genes of prognostic value in the breast cancer microenvironment. | LU YANG YUN LIU BOKE ZHANG MENGSI YU FEN HUANG YANG WEN JIANGZHENG ZENG YANDA LU CHANGCHENG YANG | 2022 | BIOCELL2022，46，5： | 1 |
| 11 | Daily variation in body mass and thermoregulation in male Hwamei(Garrulax canorus) at different seasons显示文摘Background: Acclimatization to winter conditions is an essential prerequisite for survival of small passerines of the northern temperate zone. In the present study, we measured diurnal variations in body mass, body temperature and basal metabolic rate(BMR) for seasonally acclimatized Hwameis(Garrulax canorus).Methods: Body mass was determined with a Sartorius balance. Metabolic rates of Hwameis were measured with an open-circuit respirometry system.Results: Body masses varied with time of day and were higher in daytime for Hwameis in both summer and winter, and body masses in winter were higher compared to that in summer. Body temperatures of Hwameis were higher in daytime, and the summer acclimatized birds had significantly higher body temperatures compared to the winter acclimatized birds. BMRs of Hwameis were significantly higher during the daytime compared to the nighttime of the daily cycle in both summer and winter, and Hwameis in winter had significantly higher BMRs than that in summer.Conclusions: This result showed that Hwameis rely mostly on metabolic capacity to maintain their body temperature in cold weathers, and Hwameis exhibited daily and seasonal flexibility in morphology and physiology which is important under changing environmental conditions. | Lidan Zhao Runmei Wang Yunan Wu Mengsi Wu Weihong Zheng Jinsong Liu | 2015 | Chinese Birds2015，，1： | 1 |
| 12 | Efficient degradation of atrazine through in-situ anchoring NiCo_(2)O_(4) nanosheets on biochar to activate sulfite under neutral condition显示文摘Sulfite (S(IV)) is a promising substitute for sulfate radical-based advanced oxidation processes.Here,a composite of in-situ anchoring Ni Co_(2)O_(4)nanosheets on biochar (BC) was firstly employed as a heterogeneous activator for sulfite (Ni Co_(2)O_(4)@BC-sulfite) to degrade atrazine (ATZ) in the neutral environment.The synergistic coupling of BC and Ni Co_(2)O_(4)endows the resulting composite excellent catalytic activity.82% of the degradation ratio of ATZ (1 mg/L) could be achieved within 10 min at initial concentrations of 0.6 g/L Ni Co_(2)O_(4)@BC,3.0 mmol/L sulfite in neutral environment.When further supplementing sulfite into the system at 20 min (considering the depletion of sulfite),outstanding degradation efficiency (100%) were achieved in the next 10 min without any other energy input by the Ni Co_(2)O_(4)@BC-sulfite system.The features of the prepared catalysts and the effects of some key parameters on ATZ degradation were systematically examined.A strong inner-sphere complexation (≡Co_(2)+/Ni^(2+)-SO_(3)^(2-)) was explored between sulfite and the metal sites on the Ni Co_(2)O_(4)@BC surface.The redox cycle of the surface metal efficiently mediated sulfite activation and triggered the series radical chain reactions.The generated radicals,in particular the surface-bound radicals were involved in ATZ degradation.High performance liquid chromatography-tandem mass spectrometry (LC-MS) technique was used to detect the degradation intermediates.Density functional theory (DFT) calculations were performed to illustrate the possible degradation pathways of ATZ.Finally,an underlying mechanism for ATZ removal was proposed.The present study offered a low-cost and sustainable catalyst for sulfite activation to remove ATZ in an environmentally friendly manner from wastewater. | Lizhen Feng Yijin Yuan Xianqin He Mengsi Wu Lizhi Zhang Jingming Gong | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 13 | Decomposition for Influence Factors of Carbon Emissions in the Region of Beijing, Tianjin and Hebei --Based on the Perspective of Terminal Energy显示文摘 | Xiaohong Yu Mengsi Zhang | 2014 | 环境科学前沿(中英文版)2014，3，2： | 1 |
| 14 | 异色暹罗 泰国珠宝和当代艺术之旅显示文摘2016年春,应泰国旅游局所邀,《缤纷SPACE》随同中国媒体团对泰国进行了为期一周的深度文化之旅。沿着色彩斑斓,星浪璀璨的东海岸,一路从序他武里到芭提雅,最后又回到天空之城的曼谷。这既是一条风光旎丽的地理概念的路线,也是一条串联了泰国经济文化脉络的旅途。 | mengsi | 2016 | 缤纷2016，0，8： | 0 |
| 15 | Effects of various donor:acceptor blend ratios on photophysical properties in non-fullerene organic bulk heterojunctions显示文摘The composition ratio of donor and acceptor materials in organic bulk heterojunction (BHJ) is one of the key parameters to govern the performance in organic solar cells (OSCs). Therefore, high-performance non-fullerene organic bulk heterojunction consisting of poly[(2,6-(4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b' ]dithiophene))-co-(1,3-di(5-thiophene-2-yl)–5,7-bis(2-ethylhexyl) benzo[1,2-c:4,5-c']dithiophene-4,8-dione)] (PBDB-T) and 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone))–5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2' ,3'-d' ]-s-indaceno[1,2-b:5,6-b' ]-dithio-phene (ITIC) are used to investigate the correlation among various donor: acceptor (D:A) ratios, photophysical properties and photovoltaic performance. Interestingly, the function of short-circuit current (Jsc) and D:A ratios demonstrates an axisymmetric trend. When the blending ratio of D:A deviates from the optimal ratio, the symmetrically decreased Jsc is derived from a reduction in the D:A interface or amorphous region. Research on the steady-state photoluminescence (PL), the time-resolved fluorescence spectroscopy measurements, atomic force microscopic (AFM) and grazing-incidence small angle X-rays scattering (GIWAXS) indicates no significant variation in energy loss in the process of changing D:A ratios in BHJs. With high donor or acceptor content, the domain size improves significantly, but the distance of π-π stacking corresponding to molecular packing has not changed significantly, and the bi-continuous percolation pathways were not obviously influenced. | Zhenchuan Wen Xuejian Ma Xiaoyu Yang Pengqing Bi Mengsi Niu Kangning Zhang Lin Feng Xiaotao Hao | 2019 | Chinese Chemical Letters2019，30，5： | 0 |
| 16 | Pharmacological effects of denervated muscle atrophy due to metabolic imbalance in different periods显示文摘Denervation-induced skeletal muscle atrophy can potentially cause the decline in the quality of life of patients and an increased risk of mortality.Complex pathophysiological mechanisms with dynamic alterations have been documented in skeletal muscle atrophy resulting from innervation loss.Hence,an in-depth comprehension of the key mechanisms and molecules governing skeletal muscle atrophy at varying stages,along with targeted treatment and protection,becomes essential for effective atrophy management.Our preliminary research categorizes the skeletal muscle atrophy process into four stages using microarray analysis.This review extensively discusses the pathways and molecules potentially implicated in regulating the four stages of denervation and muscle atrophy.Notably,drugs targeting the reactivare oxygen species stage and the inflammation stage assume critical roles.Timely intervention during the initial atrophy stages can expedite protection against skeletal muscle atrophy.Additionally,pharmaceutical intervention in the ubiquitin-proteasome pathway associated with atrophy and autophagy lysosomes can effectively slow down skeletal muscle atrophy.Key molecules within this stage encompass MuRF1,MAFbx,LC3II,p62/SQSTM1,etc.This review also compiles a profile of drugs with protective effects against skeletal muscle atrophy at distinct postdenervation stages,thereby augmenting the evidence base for denervation-induced skeletal muscle atrophy treatment. | JIAYING QIU YAN CHANG WENPENG LIANG MENGSI LIN HUI XU WANQING XU QINGWEN ZHU HAIBO ZHANG ZHENYU ZHANG | 2023 | BIOCELL2023，47，11： | 0 |
| 17 | miR-182-5p attenuates Schistosoma japonicum-induced hepatic fibrosis by targeting tristetraprolin显示文摘Egg granuloma formation in the liver is the main pathological lesion caused by Schistosoma japonicum infection,which generally results in liver fibrosis and may lead to death in advanced patients.MicroRNAs(miRNAs)regulate the process of liver fibrosis,but the putative function of miRNAs in liver fibrosis induced by S.japonicum infection is largely unclear.Here,we detect a new miRNA,miR-182-5p,which shows significantly decreased expression in mouse livers after stimulation by soluble egg antigen(SEA)of S.japonicum or S.japonicum infection.Knockdown or overexpression of miR-182-5p in vitro causes the increased or decreased expression of tristetraprolin(TTP),an important immunosuppressive protein in the process of liver fibrosis.Furthermore,knockdown of miR-182-5p in vivo upregulates TTP expression and significantly alleviates S.japonicum-induced hepatic fibrosis.Our data demonstrate that downregulation of miR-182-5p increases the expression of TTP in mouse livers following schistosome infection,which leads to destabilization of inflammatory factor mRNAs and attenuates liver fibrosis.Our results uncover fine-tuning of liver inflammatory reactions related to liver fibrosis caused by S.japonicum infection and provide new insights into the regulation of schistosomiasis-induced hepatic fibrosis. | Xuejun Zhao Zijie Xia Ziang Wang Mengsi Zhou Xuebing Qiu Cheng Wang Tian Xu Qian Fang Zhenping Ming Huifen Dong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 0 |
| 18 | Light polarization and color from guided‐mode resonance filter显示文摘The characteristics of reflected light of a 1-D guided-mode resonance filter(GMRF)are studied in this paper.A triple-layer GMRF is designed by using the finite difference time domain method under non-polarized light illumination.Numerical results show that the reflectance spectra of TE and TM polarizations can be changed by altering the fill factor f of the GMRF.Moreover,by calculating the color of the reflected light with the chromaticity theory,we find that the color of reflected light becomes pure when f is 0.9.The results show that the color and polarization degree of the reflected light of a GMRF are tunable by altering the fill factor. | Zhibin Ren Yahui Sun Jiasheng Hu Mengsi Li Kaipeng Zhang | 2017 | 光电工程2017，44，11： | 0 |
| 19 | Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas显示文摘Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical outcomes.Unlike WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options.The recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH entity.In the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling pathway.Disruption of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in mice.Moreover,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the patients.Thus,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH MBs.Our findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs. | Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan Qinghua Ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 20 | High-end equipment customer requirement analysis based on opinion extraction显示文摘Acquisition and analysis of customer requirements are the essential steps in high-end equipment design.Considering that Internet and big data technologies are integrated into the manufacturing industry, we propose a method of analyzing customer requirements based on open-source data. First, online data are collected with focused crawlers and preprocessed to filter noise and duplicate. Then, user opinions are extracted based on the defined template, and users' sentiments are analyzed.Based on the relationship between user sentiments and attribute parameters, the parameter range that satisfies customers can be obtained. The proposed method is evaluated by using an example of new energy vehicle to verify its availability and feasibility. | Yuejin TAN Yuren WANG Xin LU Mengsi CAI Bingfeng GE | 2018 | Frontiers of Engineering Management2018，5，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员