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| 1 | Analysis of status and countermeasures of cancer incidence and mortality in China显示文摘Cancer is the leading cause of human deaths in the world and produces serious economic burdens. On September 12, 2018, the academic journal A Cancer Journal for Clinicians published an article about the latest statistics of cancers worldwide, which provided a status report on the global burden of 36 cancers in 185 countries worldwide. Cancer has also become a serious public health problem in China and caused more and more attention of the government and people in recent years. This review analyzes the incidence, mortality and prevalent trend of cancers in China, discusses the reasons behind this status, and reviews the potential countermeasures for cancer prevention and control in China. | Chunchun Wu Mengna Li Hanbing Meng Yukun Liu Weihong Niu Yao Zhou Ran Zhao Yumei Duan Zhaoyang Zeng Xiaoling Li Guiyuan Li Wei Xiong Ming Zhou | 2019 | Science China(Life Sciences)2019，62，5： | 175 |
| 2 | Characterization and Source Apportionment of Volatile Organic Compounds in Urban and Suburban Tianjin, China显示文摘Tianjin is the third largest megacity and the fastest growth area in China, and consequently faces the problems of surface ozone and haze episodes. This study measures and characterizes volatile organic compounds(VOCs), which are ozone precursors, to identify their possible sources and evaluate their contribution to ozone formation in urban and suburban Tianjin,China during the Ha Chi(Haze in China) summer campaign in 2009. A total of 107 species of ambient VOCs were detected,and the average concentrations of VOCs at urban and suburban sites were 92 and 174 ppbv, respectively. Of those, 51 species of VOCs were extracted to analyze the possible VOC sources using positive matrix factorization. The identified sources of VOCs were significantly related to vehicular activities, which specifically contributed 60% to urban and 42% to suburban VOCs loadings in Tianjin. Industrial emission was the second most prominent source of ambient VOCs in both urban and suburban areas, although the contribution of industry in the suburban area(36%) was much higher than that at the urban area(16%). We conclude that controlling vehicle emissions should be a top priority for VOC reduction, and that fast industrialization and urbanization causes air pollution to be more complex due to the combined emission of VOCs from industry and daily life, especially in suburban areas. | HAN Meng LU Xueqiang ZHAO Chunsheng RAN Liang HAN Suqin | 2015 | Advances in Atmospheric Sciences2015，32，3： | 16 |
| 3 | Fractional Fourier domain analysis of decimation and interpolation显示文摘The sampling rate conversion is always used in order to decrease computational amount and storage load in a system. The fractional Fourier transform (FRFT) is a powerful tool for the analysis of nonstationary signals, especially, chirp-like signal. Thus, it has become an active area in the signal processing community, with many applications of radar, communication, electronic warfare, and information security. Therefore, it is necessary for us to generalize the theorem for Fourier domain analysis of decimation and interpolation. Firstly, this paper defines the digital fre- quency in the fractional Fourier domain (FRFD) through the sampling theorems with FRFT. Secondly, FRFD analysis of decimation and interpolation is proposed in this paper with digital frequency in FRFD followed by the studies of interpolation filter and decimation filter in FRFD. Using these results, FRFD analysis of the sam- pling rate conversion by a rational factor is illustrated. The noble identities of decimation and interpolation in FRFD are then deduced using previous results and the fractional convolution theorem. The proposed theorems in this study are the bases for the generalizations of the multirate signal processing in FRFD, which can advance the filter banks theorems in FRFD. Finally, the theorems introduced in this paper are validated by simulations. | MENG XiangYi TAO Ran WANG Yue | 2007 | Science in China(Series F)2007，50，4： | 15 |
| 4 | Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells显示文摘Apigenin (4',5,7-trihydroxyflavone) is a member of the flavone subclass of flavonoids present in fruits and vegetables. The involvement of autophagy in the apigenin-induced apoptotic death of human breast cancer cells was investigated. Cell proliferation and viability were assessed by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) and clonogenic assays. Flow cytometry, fluorescent staining and Western blot analysis were employed to detect apoptosis and autophagy, and the role of autophagy was assessed using autophagy inhibitors. Apigenin dose- and time-dependently repressed the proliferation and clonogenic survival of the human breast cancer T47D and MDA-MB-231 cell lines. The death of T47D and MDA-MB-231 cells was due to apoptosis associated with increased levels of Caspase3, PARP cleavage and Bax/Bcl-2 ratios. The results from flow cytometry and fluorescent staining also verified the occurrence of apoptosis. In addition, the apigenin-treated cells exhibited autophagy, as characterized by the appearance of autophagosomes under fluorescence microscopy and the accumulation of acidic vesicular organelles (AVOs) by flow cytometry. Furthermore, the results of the Western blot analysis revealed that the level of LC3-II, the processed form of LC3-I, was increased. Treatment with the autophagy inhibitor, 3-methyladenine (3-MA), significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the level of PARP cleavage. Similar results were also confirmed by flow cytometry and fluorescence microscopy. These results indicate that apigenin has apoptosis-and autophagy-inducing effects in breast cancer cells. Autophagy plays a cyto-protective role in apigenin-induced apoptosis, and the combination of apigenin and an autophagy inhibitor may be a promising strategy for breast cancer control. | Xuchen Cao Bowen Liu Wenfeng Cao Weiran Zhang Fei Zhang Hongmeng Zhao Ran Meng Lin Zhang Ruifang Niu Xishan Hao Bin Zhang | 2013 | Chinese Journal of Cancer Research2013，25，2： | 12 |
| 5 | Annual 30-m land use/land cover maps of China for 1980–2015 from the integration of AVHRR, MODIS and Landsat data using the BFAST algorithm显示文摘Annual land use land cover(LULC)change information at medium spatial resolution(i.e.at 30 m)is required in numerous subjects,such as biophysical modelling,land management and global change studies.Annual LULC information,however,is usually not available at continental or national scale due to reasons such as insufficient remote sensing data coverage or lack of computational capabilities.Here we integrate high temporal resolution and coarse spatial resolution satellite images(i.e.,Moderate Resolution Imaging Spectroradiometer(MODIS)and Global Inventory Modelling and Mapping Studies(GIMMS)normalized difference vegetation index(NDVI))with high spatial resolution datasets(China’s Land-Use/cover Datasets(CLUDs)derived from 30-meter Landsat TM/ETM+/OLI)to generate reliable annual nominal 30 m LULC maps for the whole of China between 1980 and 2015.We also test the performance of a statistical based change detection algorithm(Breaks for Additive Seasonal and Trend),originally designed for tracking forest change,in classifying all-type LULC change.As a result,a nominal 30 m annual land use/land cover datasets(CLUD-A)from 1980 to 2015 was developed for the whole China.The mapping results were assessed with a change sample dataset,a regional annual validation sample set and a three-year China sample set.Of the detected change years,75.61%matched the exact time of conversion within±1 year.Annual mapping results provided a detail process of urbanization,deforestation,afforestation,water and cropland dynamics over the past 36 years.The consistent characterization of land change dynamics for China can be further used in scientific research and to support land management for policy-makers. | Yidi XU Le YU Dailiang PENG Jiyao ZHAO Yuqi CHENG Xiaoxuan LIU Wei LI Ran MENG Xinliang XU Peng GONG | 2020 | Science China Earth Sciences2020，63，9： | 12 |
| 6 | Geochronology and petrogenesis of the mafic dykes from the Purang ophiolite:Implications for evolution of the western Yarlung-Tsangpo suture zone,southwestern Tibet显示文摘The>2000 km Indus-Yarlung Tsangpo suture zone(IYSZ)is composed of the Neo-tethys oceanic remnants,flysch units and related continental rocks,which has been regarded as the boundary between the Eurasian and Indian terranes.Among the ophiolitic complexes,the Purang ophiolite is the biggest massif in the IYSZ,and many studies have been conducted on this ophiolite.However,previous studies have mainly focused on harzburgite,clinopyroxenite and dunite.Field observations show that mafic dykes were emplaced within the Purang ophiolite.However,petrogenetic evolutions of those mafic dykes are poorly understood.In this study,we present new LA-ICP-MS zircon U-Pb dating results,whole-rock geochemistry and Sr-Nd-Hf isotope analyses for microgabbro,gabbro and dolerite dykes from the Purang ophiolite of the southwestern IYSZ,respectively.Three samples yielded zircon U-Pb ages of144.2±2.1 Ma.127.9±2.3 Ma and 126.5±0.42 Ma,suggesting two different phases of magmatic activities distinctly.Whole-rock geochemical results suggest that the gabbro samples show alkaline features marked by enrichments of light rare earth elements(LREE)and large-ion lithophile elements(LILE),as well as Nb-Ta elements,suggesting an oceanic island basalt-like(OIB-like)geochemical affinity.However,the dolerite and microgabbro samples demonstrate sub-alkaline characteristics with normal mid-oceanic ridge basalt-like(N-MORB-like)geochemical features.Three distinct mafic dykes show significant Rb element depletion.The geochemical data and Sr-Nd-Hf isotopic features suggest that the microgabbro and gabbro rocks were derived from a depleted mantle that had been metasomatized by partial melts of sediments and enriched slab-derived fluids.The dolerite was also originated from a depleted mantle marked by significantly depleted Sr-Nd-Hf compositions,which was not influenced by enriched slab-derived fluids and sediments contamination during subsequent evolution.The isotope and geochemical data and tectonic diagrams suggest a tectonic transition from a within-plate to a midoceanic ridge basalt-like(MORB-like)setting during the period from ca.144 Ma to 127 Ma.Combined with regional background and this study,we propose that these mafic dykes were formed in an oceanic back-arc basin setting.Additionally,integrated with previous studies,we suggest that the geodynamic evolution of the southwestern and central parts of the Neo-Tethys oceanic basin is comparable in Early Cretaceous. | Fahui Xiong Yuanku Meng Jingsui Yang Zhao Liu Xiangzhen Xu Alireza Eslami Ran Zhang | 2020 | Geoscience Frontiers2020，11，1： | 10 |
| 7 | miR-93-5p Transferred by Exosomes Promotes the Proliferation of Esophageal Cancer Cells via Intercellular Communication by Targeting PTEN显示文摘Objective To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells,exerted through exosomes.Methods The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis. The effect of miR-93-5p on the biological function of recipient cells was investigated by establishing an in vitro donor cell co-culture model. The target gene of miR-93-5p was validated by luciferase reporter assay and Western Blotting.Results Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin D1.Conclusion Our study provides a reference for the identification of biomarkers for the diagnosis and prognosis of esophageal cancer. | LIU Meng Xin LIAO Juan XIE Ming GAO Zhi Kui WANG Xiang Hu ZHANG Ying SHANG Mu He YIN Li Hong PU Yue Pu LIU Ran | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 8 | Rationale and Study Design for a Single-Arm Phase Ila Study Investigating Feasibility of Preventing Ischemic Cerebrovascular Events in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events Using Remote Ischemic Conditioning显示文摘 | Shi-Meng Liu Wen-Le Zhao Hai-Qing Song Ran Meng Si-Jie Li Chang-Hong Ren Bruce Ovbiagele Xun-Ming Ji Wu-Wei Feng | 2018 | Chinese Medical Journal2018，，3： | 8 |
| 9 | CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6显示文摘睫是毛一般的细胞器从房间表面延长与重要感觉并且活动性功能。睫的缺点能导致作为 ciliopathies 知道的大量人的疾病。然而,控制 ciliogenesis 的分子的机制仍然保持糟糕定义。这里,我们显示出那 cylindromatosis (CYLD ) ,怀有 deubiquitinase 活动的肿瘤 suppressor 蛋白质,在多重机关在主要、能动的睫的集会起一个关键作用。CYLD 猛烈老鼠 polydactyly 展出并且各种各样的睫的缺点,例如在基础身体抛锚和基础身体和 axenomes 的组织的破坏的失败。CYLD 的睫的功能部分从 70 kDa (Cep70 ) 的 centrosomal 蛋白质被归因于它 polyubiquitin 链的 deconjugation,为 Cep70 到的一个要求与 γ 交往;导管素并且在中心体本地化。另外, histone deacetylase 的调停 CYLD 的抑制 6 (HDAC6 ) ,它支持导管素 acetylation,为 CYLD 的睫的功能组成另一机制。HDAC6 的小分子的禁止者能部分在 CYLD 猛烈老鼠救睫的缺点。这些调查结果在 ciliogenesis 的调整强调蛋白质 ubiquitination 的重要性,作为这个过程的一个关键管理者识别 CYLD,并且建议在 ciliopathies 的 CYLD 缺乏的参与。 | Yunfan Yang Jie Ran Min Liu Dengwen Li Yuanyuan Li Xingjuan Shi Dan Meng Junmin Pan Guangshuo Ou Rim Aneja Sbao-Cong Sun Jun Zhou | 2014 | Cell Research2014，24，11： | 8 |
| 10 | The role of non-coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential显示文摘Oral squamous cell carcinoma(OSCC),the eighth most prevalent cancer in the world,arises from the interaction of multiple factors including tobacco,alcohol consumption,and betel quid.Chemotherapeutic agents such as cisplatin,5-fluorouracil,and paclitaxel have now become the first-line options for OSCC patients.Nevertheless,most OSCC patients eventually acquire drug resistance,leading to poor prognosis.With the discovery and identification of non-coding RNAs(ncRNAs),the functions of dysregulated ncRNAs in OSCC development and drug resistance are gradually being widely recognized.The mechanisms of drug resistance of OSCC are intricate and involve drug efflux,epithelial-mesenchymal transition,DNA damage repair,and autophagy.At present,strategies to explore the reversal of drug resistance of OSCC need to be urgently developed.Nano-delivery and self-cellular drug delivery platforms are considered as effective strategies to overcome drug resistance due to their tumor targeting,controlled release,and consistent pharmacokinetic profiles.In particular,the combined application of new technologies(including CRISPR systems)opened up new horizons for the treatment of drug resistance of OSCC.Hence,this review explored emerging regulatory functions of ncRNAs in drug resistance of OSCC,elucidated multiple ncRNA-meditated mechanisms of drug resistance of OSCC,and discussed the potential value of drug delivery platforms using nanoparticles and self-cells as carriers in drug resistance of OSCC. | Xiang Meng Qiu-Yue Lou Wen-Ying Yang Yue-Rong Wang Ran Chen Lu Wang Tao Xu Lei Zhang | 2021 | Cancer Communications2021，41，10： | 8 |
| 11 | Novel Prognostic Models for Predicting the 180-day Outcome for Patients with Hepatitis-B Virus-related Acute-on-chronic Liver Failure显示文摘Background and Aims:It remains difficult to forecast the 180-day prognosis of patients with hepatitis B virus-acuteon-chronic liver failure(HBV-ACLF)using existing prognostic models.The present study aimed to derive novel-innovative models to enhance the predictive effectiveness of the 180-day mortality in HBV-ACLF.Methods:The present cohort study examined 171 HBV-ACLF patients(non-survivors,n=62;survivors,n=109).The 27 retrospectively collected parameters included the basic demographic characteristics,clinical comorbidities,and laboratory values.Backward stepwise logistic regression(LR)and the classification and regression tree(CART)analysis were used to derive two predictive models.Meanwhile,a nomogram was created based on the LR analysis.The accuracy of the LR and CART model was detected through the area under the receiver operating characteristic curve(AUROC),compared with model of end-stage liver disease(MELD)scores.Results:Among 171 HBV-ACLF patients,the mean age was 45.17 years-old,and 11.7%of the patients were female.The LR model was constructed with six independent factors,which included age,total bilirubin,prothrombin activity,lymphocytes,monocytes and hepatic encephalopathy.The following seven variables were the prognostic factors for HBV-ACLF in the CART model:age,total bilirubin,prothrombin time,lymphocytes,neutrophils,monocytes,and blood urea nitrogen.The AUROC for the CART model(0.878)was similar to that for the LR model(0.878,p=0.898),and this exceeded that for the MELD scores(0.728,p<0.0001).Conclusions:The LR and CART model are both superior to the MELD scores in predicting the 180-day mortality of patients with HBV-ACLF.Both the LR and CART model can be used as medical decision-making tools by clinicians. | Ran Xue Jun Yang Jing Wu Zhongying Wang Qinghua Meng | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 8 |
| 12 | A new panaxadiol from the acid hydrolysate of Panax ginseng显示文摘新 panaxadiol (化合物 1 ) 从人参属人参 C. 迈耶·阿(Araliaceae ) 的全部的人参皂甙的酸 hydrolysate 被获得。根据分光镜的数据和单个水晶的 X 光检查衍射数据,它的化学结构被阐明是马树脂 --(E)-20(22)-ene-3β,12β,25-triol。 | Li Na Tao Qin Meng Jian Yuan Yin Rui Xing Hao Ran Guo | 2009 | Chinese Chemical Letters2009，20，6： | 7 |
| 13 | Optimization design of prestressed concrete wind-turbine tower显示文摘Wind energy is a clean and renewable energy for which technology has developed rapidly in recent years.Wind turbines are commonly supported on tubular steel towers.As the turbine size is growing and the towers are rising in height,steel towers are required to be sufficiently strong and stiff,consequently leading to high construction costs.To tackle this problem,a new type of prestressed concrete tower was designed employing a novel tower concept having a regular octagon cross section with interior ribs on each side,which was optimized by comparing the natural frequency and stress difference under the same lateral load in different directions of the tower.The designed tower features a tapered profile that reduces the area subjected to wind;the tapered profile reduces the total weight,applied moment and the capital cost.An optimization method was developed employing ABAQUS software and a genetic algorithm.A target function was defined on the basis of the minimum cost of the concrete and prestressed tendon used,and constraints were applied by accounting for the stress,displacements and natural frequency of the tower.Employing the method,a 100 m prestressed concrete tower system for a 5 MW turbine was optimized and designed under wind and earthquake loads.The paper also reports a systematic design procedure incorporating the finite element method and the optimization method for the prestressed concrete wind-turbine towers. | MA HongWang MENG Ran | 2014 | Science China(Technological Sciences)2014，57，2： | 6 |
| 14 | Nonlinear regression model for peak-failure strength of rockfill materials in general stress space显示文摘A nonlinear regression model for peak-failure strength prediction of rockfill materials is proposed. It is based on the relationship between the peak-failure stress ratio and the normalized confining pressure as well as the relationship between the normalized peak-failure stress ratio and the exponent function of the intermediate principal stress ratio. This model can well predict the variations of the peak-failure stress ratio with the initial confining pressure and the intermediate principal stress ratio for different rockfill materials under different general stress paths. Comparisons of the measured and predicted results show that the peak-failure strength under the constant-p' and constant-b path is larger than that under the constant-σ'_3 and constant-b path. The predictive capacity of the proposed model for the peakfailure stress ratio is better than that for the peak-failure friction angle. | Yang Xiao Minqiang Meng Hui Chen Xiang He Jinyu Ran Weicheng Shi | 2018 | Geoscience Frontiers2018，9，6： | 6 |
| 15 | Direct growth of ordered N-doped carbon nanotube arrays on carbon fiber cloth as a free-standing and binder-free air electrode for flexible quasi-solid-state rechargeable Zn-Air batteries显示文摘The development of an air electrode that is flexible in physical property and highly active and durable at different geometric status for both oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is of crucial importance for the rational design of flexible rechargeable Zn-air batteries(ZABs).Considering their good elasticity,high conductivity,and superior thermal and chemical stability,carbon nanotubes have been widely used as a catalyst support in various electrocatalysts,while oxide or metal nanoparticles have been frequently deposited on the carbon nanotube substrate to perform as the active materials.Considering the poor contact between active materials and carbon nanotubes may introduce a challenge for long-term operating stability,in particular in flexible devices,pure carbon electrocatalyst is highly appreciated.Herein,a free-standing air electrode with cobalt nanoparticles encapsulated N-codoped carbon nanotube arrays uniformly grown on the surface of carbon fiber cloth is developed by a two-step in situ growth method.Such a carbon-based electrode shows outstanding activity for both ORR and OER.The flexible ZAB with such air electrode shows superior flexibility and stability working under extreme bending conditions.Moreover,the polarization and round-trip efficiency for the flexible battery is 0.67 V and 64.4%at 2 mA/cm2,respectively,even after being operated for 30 hours.This study provides a feasible way to design all carbon-based free-standing and flexible electrode and enlightens the electrode design for flexible energy conversion/storage devices. | Qian Lu Xiaohong Zou Kaiming Liao Ran Ran Wei Zhou Meng Ni Zongping Shao | 2020 | Carbon Energy2020，2，3： | 6 |
| 16 | Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2显示文摘AIM:To investigate the biological features of hepatitis B virus(HBV)-transfected HepG2.2.15 cells. METHODS:The cell ultrastructure,cell cycle and apoptosis,and the abilities of proliferation and invasion of HBV-transfected HepG2.2.15 and the parent HepG2 cells were examined by electron microscopy,flow cytometry, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and trans-well assay.Oncogenicity of the two cell lines was compared via subcutaneous injection and orthotopic injection or implantation in nude mice,and the pathological analysis of tumor formation was performed.Two cytoskeletal proteins were detected by Western blotting. RESULTS:Compared with HepG2 cells,HepG2.2.15 cells showed organelle degeneration and filopodia disappearance under electron microscope.HepG2.2.15 cells proliferated and migrated slowly in vitro,and hardly formed tumor and lung metastasis in nude mice.Flow cytometry showed that the majority of HepG2.2.15 cells were arrested in G1 phase,and apoptosis was minor in both cell lines.Furthermore,the levels of cytoskeletal proteins F-actin and Ezrin were decreased in HepG2.2.15 cells. CONCLUSION:HepG2.2.15 cells demonstrated a lower proliferation and invasion ability than the HepG2 cells due to HBV transfection. | Ran Zhao Tian-Zhen Wang Dan Kong Lei Zhang Hong-Xue Meng Yang Jiang Yi-Qi Wu Zu-Xi Yu Xiao-Ming Jin | 2011 | World Journal of Gastroenterology2011，17，9： | 5 |
| 17 | Tree of life for the genera of Chinese vascular plants显示文摘我们重建了使用的中国脉管的植物(Tracheophyta ) 的一棵种系发生的树叶绿体基因 atpB, matK, ndhF,和 rbcL 和 mitochondrial matR 定序。我们生产了包括 6098 种类并且包括 13 个 695 DNA 序列, 1803 最新被产生的一个矩阵。我们的分类采样跨越了代表中国脉管的植物的 323 个家庭的 3114 个类,盖住从中国知道的超过 93% 所有类。全面大发展史支持大多数关系在之中并且在最近的分子的种系发生的研究为 lycophytes,蕨纲植物(monilophytes ) ,裸子植物,和被子植物认出的家庭以内。为被子植物,在被子植物发展史组 IV 的大多数家庭作为 monophyletic 被养活,除了 paraphyletic Dipterocarpaceae 和 Santalaceae。一些大类的几个大家庭并且 monophyly 的 infrafamilial 关系被我们的稠密的分类采样很好支持。我们的结果证明 Eberhardtia 的二种是到 Sapotaceae 的所有另外的 taxa 形成的 clade 的姐妹,除了 Sarcosperma。我们经由 SoTree (http://gffzz52bf878016c04d01hboovpcc50vnv6p5f.ffgz.tsg.suse.edu.cn/flora/index.shtml ) 做了我们为子树的创造公开地可得到的中国脉管的植物的发展史,为生态学家的一个自动化发展史集会工具。 | Zhi-Duan Chen Tuo Yang Li Lin Li-Min Lu Hong-Lei Li Miao Sun Bing Liu Min Chen Yan-Ting Niu Jian-Fei Ye Zhi-Yong Cao Hong-Mei Liu Xiao-Ming Wang Wei Wang Jing-Bo Zhang Zhen Meng Wei Cao Jian-Hui Li Sheng-Dan Wu Hui-Ling Zhao Zhong-Jian Liu Zhi-Yuan Du Qing-Feng Wang Jing Guo Xin-Xin Tan Jun-Xia Su Lin-Jing Zhang Lei-Lei Yang Yi-Ying Liao Ming-He Li Guo-Qiang Zhang Shih-Wen Chung Jian Zhang Kun-Li Xiang Rui-qi Li Douglas E. Soltis Pamela S. Soltis Shi-Liang Zhou Jin-Hua Ran Xiao-quan Wang Xiao-Hua Jin You-Sheng Chen Tian-Gang Gao Jian-Hua Li Shou-Zhou Zhang An-Ming Lu China Phylogeny Consortium | 2016 | Journal of Systematics and Evolution2016，54，4： | 5 |
| 18 | Effects of different biochars on antibiotic resistance genes during swine manure thermophilic composting显示文摘Elimination of antibiotic resistance genes(ARGs)in animal manure from concentrated animal feeding operations by thermophilic composting has drawn increasing attention.This study investigated the effects of sawdust biochar,corn stover biochar and peanut hull biochar with three spiked levels on ARGs in swine manure during thermophilic composting.Thirteen ARGs corresponding to four classes of antibiotics(tetracyclines,sulfonamides,macrolides and quinolones)were determined in the composting piles.Results indicated that the ten tested composting groups became fully mature after 30-day thermophilic composting process.tetM,tetO and ermB were reduced in all tested groups;tetC and tetG,tetX,sul1,sul2,ermF,qnrD and aac(6’)-Ib were mostly reduced under low level biochar addition but increased under higher level biochar addition;gyrA increased under medium biochar addition and reduced in other groups;oqxB remained comparatively stable throughout the composting process.The addition levels of spiked biochar are more important than types of spiked biochar on the removal of ARGs in the composting pile.The average removal rates of ARGs in the control group,low,medium and high level biochar addition groups were 0.24 logs,0.52-0.72 logs,-0.52-0.18 logs and-0.19-0.21 logs,respectively.In summary,low level biochar addition could enhance the elimination of studied ARGs in swine manure during the composting process,while medium level biochar addition to the composting piles would increase the risk of ARGs’propagation. | Jian Wang Bin Sui Yujun Shen Haibo Meng Lixin Zhao Haibin Zhou Ran Li Jingtao Ding Hongsheng Cheng Xi Zhang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 5 |
| 19 | Bioinspired hierarchical helical nanocomposite macrofibers based on bacterial cellulose nanofibers显示文摘Bio-sourced nanocellulosic materials are promising candidates for spinning high-performance sustainable macrofibers for advanced applications.Various strategies have been pursued to gain nanocellulose-based macrofibers with improved strength.However,nearly all of them have been achieved at the expense of their elongation and toughness.Inspired by the widely existed hierarchical helical and nanocomposite structural features in biosynthesized fibers exhibiting exceptional combinations of strength and toughness,we report a design strategy to make nanocellulose-based macrofibers with similar characteristics.By combining a facile wet-spinning process with a subsequent multiple wet-twisting procedure,we successfully obtain biomimetic hierarchical helical nanocomposite macrofibers based on bacterial cellulose nanofibers,realizing impressive improvement in their tensile strength,elongation and toughness simultaneously.The achievement certifies the validity of the bioinspired hierarchical helical and nanocomposite structural design proposed here.This bioinspired design strategy provides a potential platform for further optimizing or creating many more strong and tough nanocomposite fiber materials for diverse applications. | Huai-Ling Gao Ran Zhao Chen Cui Yin-Bo Zhu Si-Ming Chen Zhao Pan Yu-Feng Meng Shao-Meng Wen Chuang Liu Heng-An Wu Shu-Hong Yu | 2020 | National Science Review2020，7，1： | 4 |
| 20 | Methodology to Evaluate Fatigue Damage of High-Speed Train Welded Bogie Frames Based on On-Track Dynamic Stress Test Data显示文摘The current method of estimating the fatigue life of railway structures is to calculating the equivalent stress amplitude based on the measured stress data. However, the random of the measured data is not considered. In this paper, a new method was established to compute the equivalent stress amplitude to evaluate the fatigue damage based on the measurable randomness, since the equivalent stress is the key parameter for assessment of structure fatigue life and load derivation. The equivalent stress amplitude of a high-speed train welded bogie frame was found to obey normal distribution under uniform operation route that verified by on-track dynamic stress data, and the proposed model is, in effect, an improved version of the mathematical model used to calculate the equivalent stress amplitude. The data of a long-term, on-track dynamic stress test program was analyzed to find that the normal distribution parameters of equivalent stress amplitude values differ across different operation route. Thus, the fatigue damage of the high-speed train welded bogie frame can be evaluated by the proposed method if the running schedule of the train is known a priori. The results also showed that the equivalent stress amplitude of the region connected to the power system is more random than in other regions of the bogie frame. | Guangxue Yang Meng Wang Qiang Li Ran Ding | 2019 | Chinese Journal of Mechanical Engineering2019，32，3： | 4 |
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