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| 1 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 2 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 3 | Characterization of brain tumors by MRS,DWI and Ki-67 labeling index显示文摘 | Calvar JA Meli FJ Romero C | 2005 | J Neurooncol2005，72，3： | 1 |
| 4 | Neuronal injury in multiple sclerosis显示文摘 | Correale J Meli F Ysrraelit C | 2006 | Medicina (B Aires)2006，66，： | 1 |
| 5 | Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity显示文摘 | Rubera I Duranton C Melis N | 2013 | Cell Death Dis2013，10，4： | 1 |
| 6 | Multidisciplinary care of the patient with chronic obstructive pulmonary disease 显示文摘 | Kuzma AM Meli Y Meldrum C | 2008 | Proc Am Thorac Soc2008，5，4： | 1 |
| 7 | Oli- gomerisation of Ethylene to Linear α - Olefins by New C - and C - Symmetric - 2,6 - Bis ( imino ) pyridyl - i- ron and - Cobalt Dichloride Complexes 显示文摘 | BIANCHIN C MANTOVANI G MELI A | 2003 | European Journal of Inorganic Chemistry2003，，8： | 1 |
| 8 | Localization and function of SulP,a nuclear-encoded chloroplast sulfate permease in Chlamydomonas reinhardtii显示文摘 | Chen H C Melis A | 2004 | Planta2004，220，： | 1 |
| 9 | Multidisciplinary care of the patient with chronic obstructive pulmonary disease显示文摘 | Kuzma AM Meli Y Meldrum C | | 0，，： | 1 |
| 10 | Atypical odontalgia: A review of the literature显示文摘 | Melis M Lobo SL Ceneviz C | 2003 | Headache2003，43，10： | 1 |
| 11 | Ahernating copolymerization of carbon monoxide and olefins by single-site metal catalysis 显示文摘 | Bianchini C Meli A | 2002 | Coordination Chemistry Reviews2002，225，12： | 1 |
| 12 | Characterization of brain tumors by MRS, DWI and Ki-67 labeling index显示文摘 | Calvar JA Meli FJ Romero C | 2005 | J Neurooncol2005，72，3： | 1 |
| 13 | Methylphenidate for pervasive developmental disorders:safety and efficacy of acute single dose test and ongoing therapy:an open-pilot study显示文摘 | DiMartino A Melis G Cianchetti C | 2004 | J Child Adolesc Psychopharmacol2004，14，2： | 1 |
| 14 | Autism and phenylketonuria显示文摘 | Baieli S Pavone L Meli C | 2003 | J Autism Dev Disord2003，33，2： | 1 |
| 15 | Muhidisciplinary care of the patient with chronic obstructive pulmonary disease 显示文摘 | Kuzma AM Meli Y Meldrum C | 2008 | Proc Am Thorac Soc2008，5，4： | 1 |
| 16 | Temperature-dependent changes in the antenna size of photosystem Ⅱ :Reversible conversion of photosystem Ⅱα to photo-system 11β 显示文摘 | Sundby C Melis A Maenpaa P | 1986 | Biochimica et Biophysica Acta (BBA)- Bioenergetics1986，，851： | 1 |
| 17 | A carbohydrate-rich beverage prior to surgery prevents surgery-induced immunodepression:a randomized,controlled,clinical trial显示文摘 | MELIS G C van LEEUWEN P A von BLOMBERG-Van der FLIER B M | 2006 | JPEN J Parenter Enteral Nutr2006，30，： | 1 |
| 18 | Moon and sun compasses in sandhoppers rely on two separate ehronometric mechanisms显示文摘 | UGOLINI A MELIS C INNOCENTI R | 1999 | Proceedings of the Royal Society of London1999，266，： | 1 |
| 19 | Clinical manifestations and management of four children with Pearson syndrome显示文摘 | Tumino M Meli C Farruggia P | 2011 | AmJ Med Genet A2011，155，12： | 1 |
| 20 | A carbohydrate-rich beverage prior to surgery prevents surgery-induced immunodepression:A randomized,controlled,clinical trial显示文摘 | Melis G C van Leeuwen P A von Blomberg-van der Flier B M | | 0，，01： | 1 |
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