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| 1 | Beyond tumorigenesis: cancer stem cells in metastasis显示文摘在肿瘤开始的癌症干细胞(CSC ) 的重要性坚定地在白血病被建立了并且最近为许多稳固的肿瘤报导了。然而,特别地关于转移,在多级式的癌症前进的 CSC 的角色有不定义 beenwell。癌症转移要求在远机关播种和 specializedCSCs 的成功的殖民。正常干细胞和 CSC 的生物学分享显著类似并且当适用于癌症的学习时,可以有重要含意转移。而且,重叠分子和小径的集合最近被识别了调整干细胞移植和癌症转移。这些分子组成两个都为移植 CSC 由主要肿瘤和养育的机关微型环境的形成便于转移前壁龛的开始的细胞的相互作用的一个复杂网络。在这评论,我们在这个动态领域里调查了最近的进展并且建议 CSC 在 tumorigenesis 和转移在假定一个中央角色的癌症前进的一个统一模型。更好作为变形串联的一个基本部件理解 ofCSCs 将对变形癌症导致新奇治疗学的策略。 | Feng Li Benjamin Tiede Joan Massague Yibin Kang | 2007 | Cell Research2007，17，1： | 85 |
| 2 | Roles of TGFβ in metastasis显示文摘表明小径的 TGF 尾从苍蝇被保存到人并且被显示了调整象房间增长,区别,活动性,粘附,组织,和规划房间死亡的如此的多样的过程。在 vitro 并且在 vivo,实验建议 TGF 尾能利用这些改变的程序在有免疫力的房间功能的肿瘤微型环境,提高的侵略性质,和抑制上通过它的效果支持癌症转移。表明在 TGF 尾发信号和癌症前进之间的一个连接的最近的临床的证据作为一个治疗学的目标在这条发信号的小径正在培养兴趣。Anti-TGF 尾治疗当前在现出症状之前的潜的研究正在被开发并且测试。当这条小径在多重 homeostatic 过程被含有并且也被知道有 tumor-suppressor 功能,然而,指向 TGF 尾带实质的风险。另外,临床、试验性的结果证明 TGF 尾甚至在一样的肿瘤类型以内在肿瘤前进有多样、经常冲突的角色。为临床的使用的 TGF 尾禁止者的发展将要求 TGF 尾在它在哪个行动发信号,它的后果,和上下文的更深的理解。 | David Padua Joan Massague | 2009 | Cell Research2009，19，1： | 52 |
| 3 | Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus显示文摘 | Yigong Shi Joan Massagué | 2003 | Cell2003，，6： | 5 |
| 4 | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma显示文摘Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. | Esther Llop Pedro E Guerrero AdriàDuran Sílvia Barrabés Anna Massaguer María JoséFerri Maite Albiol-Quer Rafael de Llorens Rosa Peracaula | 2018 | World Journal of Gastroenterology2018，24，24： | 4 |
| 5 | Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus显示文摘 | Yigong Shi Joan Massagué | 2003 | Cell2003，，6： | 4 |
| 6 | Cancer Metastasis: Building a Framework显示文摘 | Gaorav P. Gupta Joan Massagué | 2006 | Cell2006，，4： | 3 |
| 7 | TGF-beta SIGNAL TRANSDUCTION显示文摘 | J. Massague | 1998 | Annual Review of Biochemistry1998，，： | 2 |
| 8 | OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways显示文摘 | Hata A Seoane J Lagna G Montalvo E Hemmati Brivanlou A Massague J | | 0，，： | 2 |
| 9 | The logic of TGFβ signaling显示文摘 | Joan Massagué Roger R. Gomis | 2006 | FEBS Letters2006，，12： | 2 |
| 10 | Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways显示文摘 | Claudio Alarcón Alexia-Ileana Zaromytidou Qiaoran Xi Sheng Gao Jianzhong Yu Sho Fujisawa Afsar Barlas Alexandria N. Miller Katia Manova-Todorova Maria J. Macias Gopal Sapkota Duojia Pan Joan Massagué | 2009 | Cell2009，，4： | 2 |
| 11 | TGFβ in Cancer显示文摘 | Joan Massagué | 2008 | Cell2008，，2： | 2 |
| 12 | Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation显示文摘 | Alexandre Calon Elisa Espinet Sergio Palomo-Ponce Daniele V.F. Tauriello Mar Iglesias María Virtudes Céspedes Marta Sevillano Cristina Nadal Peter Jung Xiang H.-F. Zhang Daniel Byrom Antoni Riera David Rossell Ramón Mangues Joan Massagué Elena Sancho Edua | 2012 | Cancer Cell2012，，5： | 2 |
| 13 | Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway显示文摘 | Ulloa L Doody J Massague J | 1999 | Nature1999，397，： | 2 |
| 14 | TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders显示文摘 | Joan Massagué Stacy W Blain Roger S Lo | 2000 | Cell2000，，2： | 2 |
| 15 | Cloning of p57Kip2 ,a cyclin dependent kinase inhibitor with unique domain structure and tissue distribution显示文摘 | Lee MH Reynisdottir I Massague J | 1995 | Genes Dev1995，9，6： | 2 |
| 16 | TGF - β signaling in growth control, cancer, and heritable disorders 显示文摘 | Massague J Blain S W Lo R S | 2000 | Cell2000，103，2： | 1 |
| 17 | TGF-β signaling:receptors,transducers and Mad proteins显示文摘 | | 1996 | Cell1996，85，： | 1 |
| 18 | Epithelial-mesenchymal transitions:twist in development and metastasis显示文摘 | Kang Y Massague J | 2004 | Cell2004，118，3： | 1 |
| 19 | SMADs: Mediators and regula - tors of TGF - beta signaling 显示文摘 | KretzschmarM Massague J | 1998 | Curr Opin Genet Dev1998，8，1： | 1 |
| 20 | TGF- β signal transduction显示文摘 | Massague J | 1998 | Annu Rev Biochem1998，67，7： | 1 |
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