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	题名	作者	年代	出处	被引量
1	Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs:A case report显示文摘BACKGROUND Despite an expanding number of studies on intraductal papillary neoplasm of the bile duct(IPNB),distant metastasis remains unexplained especially in cases of carcinoma in situ.In the present study,we report a rare and interesting case of IPNB without invasive components that later metastasized to lungs and brain.CASE SUMMARY A 69-year-old male was referred to our hospital due to suspected cholangiocarcinoma.Laboratory tests on admission reported a mild elevation of alkaline phosphatase,γ-glutamyl transpeptidase,and total bilirubin in serum.Endoscopic retrograde cholangiography revealed a filling defect in the common bile duct(CBD)extending to the left hepatic duct.Peroral cholangioscopy delineated a tumor in the CBD that had a papillary pattern.Multidetector computed tomography and magnetic resonance cholangiopancreatography detected partial blockage ot interlude in the CBD leading to cholestasis without evidence of metastasis.Therefore,a diagnosis of IPNB cT1N0M0 was established.Left hepatectomy with bile duct reconstruction was performed.Pathological examination confirmed an intraepithelial neoplasia pattern without an invasive component and an R0 resection achievement.The patient was monitored carefully by regular examinations.However,at 32 mo after the operation,a 26 mm tumor in the lungs and a 12 mm lesion in the brain were detected following a suspicious elevated CA 19-9 level.Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated.In addition to histopathological results,a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer.CONCLUSION This case highlights the important role of genomic profiling analysis using whole exome sequencing in identifying the origin of metastasis in patients with IPNB.	Nguyen Hai Nam Kojiro Taura Masashi Kanai Keita Fukuyama Norimitsu Uza Hirona Maeda Yojiro Yutaka Toyofumi F Chen-Yoshikawa Manabu Muto Shinji Uemoto	2020	World Journal of Gastroenterology2020，26，3：	5
2	Methotrexate treatment in patients with adult onset Still's disease retrospective study of 13 Japanese cases显示文摘	Masashi A Hideto K	1997	Ann Rheum Dis1997，56，2：	1
3	c - Jun N - terminal kinase acti- vation in dorsal root ganglion contributes to pain hypersensitivity显示文摘	Hideo D Selji O Masashi F	2005	Biochemical and Biophysical Research Communications2005，434，2：	1
4	Development of local clustering organization (LCO) for solving TSP显示文摘	MASASHI F MICHIKO W	2005	Society of Mechanical Engineers2005，7，11：	1
5	Natriuretic peptides en- hance the production of adiponectin in human adipocytes and in pa- tients with chronic heart failure 显示文摘	Tsukamoto O Masashi F Kato M	2009	JACC2009，53，22：	1
6	Serpentine locomotion with robotic snakes 显示文摘	Masashi S Masakazu F Tetsuya I	2002	IEEE Control Systems Maga- zine2002，22，1：	1
7	An office--based prospective study of deafness in mumps显示文摘	Masashi F Hiroshi K	2009	The Pediatric Infectious Disease Jour- nal2009，28，：	1
8	Phosphorus accelerates the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure 显示文摘	Masashi D Jane F Eduardo S	1996	Am J Kidney Dis1996，28，4：	1
9	Prolonged transient ac- idosis during early reperfusion contributes to the cardiopro- tective effects of postconditioning 显示文摘	Masashi F Hireshi A Aldo H	2007	Am J Physiol Heart Circ Physiol2007，29，14：	1
10	A wide variety of dynamic contrast-enhanced MR apperances of breast cancer:pathologic correlation study显示文摘	Masayuki O Akira F Masashi T	2008	Euro J Radiol2008，65，：	1
11	Continuous production of phospholipase D using immobilized recombinant Streptomyces lividans 显示文摘	Chiaki O Masayuki K Masashi F	2005	Enzyme Microb Technol2005，41，12：	1
12	A novel catalytic synthesis of carbamates by oxidative alkoxycarbonylation of amines in the presence of palladium and iodide显示文摘	Shinsuke F Masazumi C Masashi K	1984	J Chem Soc Chem Commun1984，14，6：	1
13	A novel catalytic synthesis of carbamates by the oxidative alkoxycarbonylation of amines in the presence of platinum group metal and alkali metal halide or onium halide 显示文摘	Shinsuke F Masazumi C Masashi K	1984	J Org Chem1984，49，8：	1
14	Synthesis of Acetobacter xylinum bacteral cellulose composite and tis mechanical strength and biodegradability显示文摘	Kenji T Masashi F Mitsuo T	1995	Mokuzai Gakkaishi1995，41，8：	1
15	Osteoinduction of porous bioactive titanium metal 显示文摘	Shunsuke F Masashi N Kim H M	2004	Biomaterials2004，25，3：	1
16	Single dose toxicity study of ebastine in mice and rats显示文摘	Masashi Y Hideo N Akira F	1994	Jpn Pharmcol Ther1994，22，3：	1
17	Crystal growth of Ce2O(CO3)2 · H2O in aqueous solutions:Film formation and samarium doping显示文摘	MASASHI O SHINOBU F	2005	Journal of Solid State Chemistry2005，178，6：	1
18	Design of 'Tatara Bridge' 显示文摘	MASASHI Y TORU F KAZUO S	2003	Engineering Review2003，36，2：	1
19	SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cell显示文摘	Ryuji H Yoichi F Masashi M Yuko I Fabio P Silval	2004	Nature Cell Biology2004，7，6：	1
20	A novel catalytic synthesis of carbamates by oxidative alkoxycarbonylation of amines in the presence of palladium and iodide显示文摘	Shinsuke F Masazumi C Masashi K		0，，6：	1

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