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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber显示文摘Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–4.Advances in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–7.We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications.The volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core MMF.Here,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+responses.These results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo. | Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin J.Booth TomášČižmár Nigel J.Emptage | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 3 | Infrared, blue and ultraviolet upconversion emissions in Yb3+:Tm3+-doped fluoroindate glasses 显示文摘 | Martin I R Rodriguez V D Lavin V | 1999 | Spectrochimica Acta Part A1999，55，： | 2 |
| 4 | Macroporous polymer foams by hydrocarbon templating显示文摘 | Shastri VP Martin I Langer R | 2000 | Pro Nat Acad Sci USA2000，97，5： | 2 |
| 5 | Engineering of a- Si : H device stability by suitable design of interface 显示文摘 | Martins R Ferreira I Silva V | 2002 | Solar Energy Material & Solar Cells2002，，： | 1 |
| 6 | N-type emitter surface passivation in c-Si solar cells by means of antireflective amorphous silicon carbide layers显示文摘 | Ferre R Martin I Ortega P | 2006 | Journal of Applied Phycology2006，100，73： | 1 |
| 7 | 显示文摘 | MARTIN P D JONES G R STRINGER F WILSON I D | 2003 | Analyst2003，128，： | 1 |
| 8 | Ceftriaxone-induced acute reversible encephalopathy in a patient treated for a urinary tract infec- tion显示文摘 | Roncon-Albuquerque R Jr Pires I Martins R | 2009 | Neth J Med2009，67，2： | 1 |
| 9 | Layer-bylayer assembly of ultrathin composite films from micron-sized graphite oxide sheets and polycations显示文摘 | Kovtyukhova N I Ollivier P J Martin B R | | 0，，03： | 1 |
| 10 | Pulse-receiving Characteristics of V-dipole Antennas with Resistive Loading 显示文摘 | GARCIA I S BRETONES A R MARTIN R G | 1998 | IEEE Trans Antennas Propagation1998，40，2： | 1 |
| 11 | Defensins and other endogenous peptide of vertebrates显示文摘 | Martin E Ganz T Lehrer R I | 1995 | Journal of Leukocyte Biology1995，58，： | 1 |
| 12 | Technological Diffusion, Con - vergencc, and Growth 显示文摘 | Barro R Sala I - Martin X | 1997 | Journal of Economic Growth1997，，2： | 1 |
| 13 | Enhanced cartilage tissue engineering by sequential exposure of chondrocytes to FGF 2 during 2D expansion and BMP-2 during 3D cultivation显示文摘 | Martin I Suetterlin R Baschong W | | J Cell Biochem0，83，12： | 1 |
| 14 | Global Income Divergence, Trade, and Industrialization: The Geogra phy of Growth Take-offs显示文摘 | Baldwin R E Martin P Ottaviano G I P | 2001 | Journal of Economic Growth2001，6，1： | 1 |
| 15 | Pulmonary arterial hypertension:new insights and new hope 显示文摘 | Martin K B Klinger J R Rounds S I | 2006 | Respirology2006，11，1： | 1 |
| 16 | Layer-by-Layer Assembly of Ultrathin Composite Films from Micron-Sized Graphite Oxide Sheets and Polycations显示文摘 | Kovtyukbova N I Ollivier P J Martin B R | | 0，，03： | 1 |
| 17 | Ceftriax-one-induced acute reversible encephalopathy in a patient treated for a urinary tract infection显示文摘 | Roncon-Albuquerque R Jr Pires I Martins R | | 0，，02： | 1 |
| 18 | Layer-by-layer assembly of ultrathin composite films from micron-sized graphite oxide sheets and polycations显示文摘 | Kovtyukhova N I Ollivier P J Martin B R | 1999 | Chem Mater1999，11，3： | 1 |
| 19 | Color-coded ultrasound diagnosis of vascular occlusion in acute ischemic stroke显示文摘 | Martin P Pye I Abbott R | 1995 | J Neuroimaging1995，5，： | 1 |
| 20 | Surface oxida- tion effects on the optical properties of silicon nanocrystals 显示文摘 | Vasiliev I Chelikowsky J R Martin R M | 2002 | Physical Review2002，65，12： | 1 |
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