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| 1 | Percutaneous closure of secundum type atrial septal defects:More than 5-year follow-up显示文摘AIM: To investigate long-term efficacy of two different devices more than five years after percutaneous atrial septal defect(ASD) closure in adults.METHODS: All patients who underwent percutaneous closure of an ASD in the St. Antonius Hospital, Nieuwegein, The Netherlands, between February 1998 and December 2006 were included. Percutaneous closure took place under general anaesthesia and transesophageal echocardiographic moni toring. Transthoracic echocardiography(TTE) was performed 24 h post-procedure to visualize the device position and to look for residual shunting using color Doppler. All complications were registered. All patients were invited for an outpatient visit and contrast TTE more than 5-years after closure. Efficacy was based on the presence of a residual right-to-left shunt(RLS), graded as minimal, moderate or severe. The presence of a residual left-to-right shunt(LRS) was diagnosed using color Doppler, and was not graded. Descriptive statistics were used for patients' characteristics. Univariate analysis was used to identify predictors for residual shunting.RESULTS: In total, 104 patients(mean age 45.5 ± 17.1 years) underwent percutaneous ASD closure using an Amplatzer device(ASO) in 76 patients and a Cardioseal/Starflex device(CS/SF) in 28 patients. The mean follow-up was 6.4 ± 3.4 years. Device migration occurred in 4 patients of whom two cases occurred during the index hospitalization(1 ASO, 1 CS/SF). The other 2 cases of device migration occurred during the first 6 mo of follow-up(2 CS/SF). The recurrent thrombo-embolic event rate was similar in both groups: 0.4% per follow-up year. More than 12 mo post-ASD closure and latest follow-up, new-onset supraventricular tachyarrhythmia's occurred in 3.9% and 0% for the ASO and CS/SF group, respectively. The RLS rate at latest follow-up was 17.4%(minimal 10.9%, moderate 2.2%, severe 4.3%) and 45.5%(minimal 27.3%, moderate 18.2%, severe 0%) for the ASO- and CS/SF groups, respectively. There was no residual LRS in both groups.CONCLUSION: Percutaneous ASD closure has good long-term safety and efficacy profiles. The residual RLS rate seems to be high more than 5 years after closure, especially in the CS/SF. Residual LRS was not observed. | Roel JR Snijder Maarten J Suttorp Jurrien M Ten Berg Martijn C Post | 2015 | World Journal of Cardiology2015，7，3： | 6 |
| 2 | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation显示文摘BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis.In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic control.AIM To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with Aramchol.METHODS Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 h.Subsequently,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled glucose.For the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 wk.Liver metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related metabolites.RESULTS Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes.This translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA cycle.Finally,liver metabolomic analysis showed that glucose homeostasis was improved by Aramchol in 0.1MCD fed mice in a dose-dependent manner,showing normalization of glucose,G6P,F6P,UDP-glucose,and Rbl5P/Xyl5P.CONCLUSION Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1,which in turn activate FAβ-oxidation and oxidative phosphorylation. | David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | Pulmonary hypertension in hereditary haemorrhagic telangiectasia显示文摘Hereditary haemorrhagic telangiectasia(HHT) is an autosomal dominant inherited disorder characterised by vascular malformations in predominantly the brain,liverand lungs.Pulmonary hypertension(PH) is increasingly recognised as a severe complication of HHT.PH may be categorised into two distinct types in patients with HHT.Post-capillary PH most often results from a high pulmonary blood flow that accompanies the high cardiac output state associated with liver arteriovenous malformations.Less frequently,the HHT-related gene mutations in ENG or ACVRL1 appear to predispose patients with HHT to develop pre-capillary pulmonary arterial hypertension.Differentiation between both forms of PH by right heart catheterisation is essential,since both entities are associated with severe morbidity and mortality with different treatment options.Therefore all HHT patients should be referred to an HHT centre. | Veronique MM Vorselaars Sebastiaan Velthuis Repke J Snijder Jan Albert Vos Johannes J Mager Martijn C Post | 2015 | World Journal of Cardiology2015，7，5： | 4 |
| 4 | Coupled modes and the nonlinear Sehrodingers equation 显示文摘 | Martijn de Sterke C Sipe J E | 1994 | Prog Opt1994，33，： | 1 |
| 5 | High-Intensity Pulse Progation in uniform Gratings and Grating Superstructures 显示文摘 | de Sterke C Martijn Eggleton Benjamin J Krug Peter A | 1997 | Journal of Lightwave Technology1997，15，8： | 1 |
| 6 | Dispersionless slow light using gap solitons显示文摘 | Mok J T Martijn C Sterke D | 2006 | Nature Physics2006，2，： | 1 |
| 7 | Overcoming ego depletion: The influence of exemplar priming on self-control performance显示文摘 | MARTIJN C ALBERTS H J E M MERCKELBACH H | 2007 | Euro J Soc Psychol2007，37，： | 1 |
| 8 | The effects of AIDS prevention programs by lay health advisors for migrants in The Netherlands 显示文摘 | Martijn C de Vries NK Voorham T | 2004 | Patient Education and Counseling2004，53，2： | 1 |
| 9 | Nega- tive and Positive Effects in Person Perception and Inference: Ability Versus Morality 显示文摘 | Martijn C Spears R Van der Pligt J | 1992 | European Journal of Social Psychology1992，22，5： | 1 |
| 10 | Overcoming ego depletion: The influence of exemplar priming on self-control performance 显示文摘 | MARTIJN C ALBERTS H J E M MERCKELBACH H | 2007 | Eur J Soc Psychol2007，37，2： | 1 |
| 11 | UV/H2O2 treatment: a practical solution for organic contaminant control and primary disinfection 显示文摘 | Joop C Kruithof Peer C Kamp Bram J Martijn | 2007 | Ozone: Science and Engineering2007，29，4： | 1 |
| 12 | Centralnervous tissue damage after hypoxia and reperfusion inconjunction with cardiac arrest and cardiopulmonaryresuscitation : mechanisms of action and possibilities formitigation显示文摘 | Wiklund L Martijn C Miclescu A | 2012 | Int Rev Neurobiol2012，102，： | 1 |
| 13 | Dispersion- less slow light using gap solitons 显示文摘 | JOE T M MARTIJN C STERKE D | 2006 | Nature Physics2006，2，： | 1 |
| 14 | Supramolecular copolyesters with tunable properties显示文摘 | D J M van Beek Martijn A J Gillissen Bart A C van As | 2007 | Macromolecules2007，40，17： | 1 |
| 15 | UV/I-I2 02 treatment :A practical solution for organic contaminant control and primary dis- infection 显示文摘 | Kruithof J C Kamp P C Martijn B J | 2007 | Ozone : Science and Engineering2007，29，4： | 1 |
| 16 | Nonlinear coupled-mode equations on a finite interval:a numerical procedure显示文摘 | MARTIJN C STERKE D KENNETH R | | 0，，： | 1 |
| 17 | Dispersionless slow light using gap solitons显示文摘 | Mok Joe T Martijn De Sterke C | 2006 | Nature Physics2006，2，： | 1 |
| 18 | Global microRNA profiling of well-differentiated small intestinal neuroendocrine tumors显示文摘 | Li SC Essaghir A Martijn C | 2013 | Mod Pathol2013，26，5： | 1 |
| 19 | A three-dimensional passive-dynamic walking robot with two legs and knees显示文摘 | STEVE C MARTIJN W ANDY R | 2001 | The International Journal of Robotics Research2001，20，7： | 1 |
| 20 | The CEO pay slice显示文摘 | Bebchuk L A Martijn Cremers K J Peyer U C | 2001 | Journal of Financial Economics2001，102，1： | 1 |
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