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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | ScaI polymorphism of the atrial natriuretic peptide gene and blood pressure in subjects without clinical manifestations of atherosclerotic disease显示文摘 | Jerzy B Marcin G Siebert J | 1999 | Arterial Hypertension1999，3，4： | 1 |
| 3 | Growth inhibition and intracellular distribution of Pb ions by the white-rot fungus Abortiporus biennis显示文摘 | MARCIN G PAWLIKOWSKA-PAWLEGA Z JAROSZ-WILKOZKA A | 2011 | Int Biodet Biodegr2011，65，： | 1 |
| 4 | Bisphosphonate sequestering agents synthesis and preliminary evaluation for in vitro and in vivo uraniurn(VI) chelation显示文摘 | Marcin S Delphine L Gerard G | 2008 | European Journal of Medicinal Chemistry2008，43，： | 1 |
| 5 | Epitaxial graphene显示文摘 | Walt A. de Heer Claire Berger Xiaosong Wu Phillip N. First Edward H. Conrad Xuebin Li Tianbo Li Michael Sprinkle Joanna Hass Marcin L. Sadowski Marek Potemski Gérard Martinez | 2007 | Solid State Communications2007，，1： | 1 |
| 6 | Optimal Medical Therapy With or Without Percutaneous Coronary Intervention to Reduce Ischemic Burden: Results From the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) Trial Nuclear Substudy显示文摘 | Leslee J. Shaw Daniel S. Berman David J. Maron G B. John Mancini Sean W. Hayes Pamela M. Hartigan William S. Weintraub Robert A. O'Rourke Marcin Dada John A. Spertus Bernard R. Chaitman John Friedman Piotr Slomka Gary V. Heller Guido Germano Gilbert Gosse | 2008 | Circulation2008，，10： | 1 |
| 7 | Frangogiannis Transforming growth factor(TGF)-βsignaling in cardiac remodeling显示文摘 | Marcin D Wei C Nikolaos G | 2011 | J Mol Cell Cardiol2011，51，4： | 1 |
| 8 | TGF-β signaling in fi- brosis显示文摘 | Anna B Marcin D Nikolaos G | 2011 | Growth Factors2011，29，5： | 1 |
| 9 | Mechanical behaviour of C45 grade steel deformed in semi-solid state 显示文摘 | MARCIN H MIROSLAW G | 2011 | Procedia Engineering2011，10，： | 1 |
| 10 | Fenofibrate attenuates contact-stimulated cell motility and gap junctionalcoupling in DU-145 human prostate cancer cell populations显示文摘 | Ewa Wybieralska Katarzyna Szpak Andrzej Górecki Piotr Bonarek Katarzyna Mi?kus Justyna Druka?a Marcin Majka Krzysztof Reiss Zbigniew Madeja Jaros?aw Czy? | 2011 | Oncology Reports2011，，2： | 1 |
| 11 | Wireless sensor networks for temperature and humidity monitoring within concrete structures显示文摘 | Norberto Barroca Luís M. Borges Fernando J. Velez Filipe Monteiro Marcin Górski Jo?o Castro-Gomes | 2012 | Construction and Building Materials2012，，： | 1 |
| 12 | Fractal dimensions of skin microcirculation flow in subjects with familial predisposition or newly diagnosed hypertension显示文摘 | Barbara G Miroslow N Marcin Z | | 0，，01： | 1 |
| 13 | Fluidity and Temperature Profile of Ductile Iron in Thin Sections显示文摘It has been shown that it is possible to produce thin wall ductile iron (TWDI) castings of considerable length using an Archimedes spirals with a wall of 1, 2 or 3 mm in thickness. The fluidities for different moulding materials [(classical mould, chemically bonded silica sand and chemically bonded low-density alumina-silicate ceramic sand (LDASC)], chemical composition, and pouring temperature were estimated. There is a significant temperature drop in thin sections (contrary to typical sections) during the mould filling. A profile of real temperature drop is presented along with theoretical predictions. The high temperature drop of liquid iron results in an increased cooling rate (before the eutectic equilibrium solidification temperature), which in turn affects the solidification and microstructure of TWDI castings. Microstructures were characterized quantitatively using an image analyser. Structure parameters for different wall thicknesses and moulding materials (graphite nodule count, ferrite and cementite fraction) are plotted, which is versus distance from the entrance to the mould cavity. It has been shown that the thin wall castings have a gradient structure. Moreover, a strong influence of LDASC sand (material with low ability to absorb the heat) on the structure parameters of TWDI castings is presented. | Marcin Górny | 2012 | Journal of Iron and Steel Research(International)2012，19，8： | 1 |
| 14 | Nitrous oxide decomposition in a real nitric acid plant gas stream with a RhOx /Ce<sup>0.9</sup>Pr<sub>0.1</sub>O<sub>2</sub>/alumina catalyst显示文摘 | Marek Inger Marcin Wilk Sonia Parres‐Esclapez Maria José Illán‐Gómez Concepción Salinas-Martínez de Lecea Agustín Bueno‐López | 2013 | J Chem Technol Biotechnol2013，，12： | 1 |
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