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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by reconditioning PCR显示文摘 | Thompson J Marcelino L Polz M | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 3 | Heteroduplexes in mixed-template amplifications:formation,consequence and elimination by 'reconditioning PCR'显示文摘 | Thompson J R Marcelino L A Polz M F | 2000 | Nucleic Acids Res2000，30，： | 1 |
| 4 | Heteroduplexes in mixedtemplate amplifications :formation ,consequence and elimination by 'reconditioning PCR'显示文摘 | THOMPSON JR MARCELINO L A POLZ M F | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 5 | Support vector regression for the simultaneous learning of a multivariate function and its derivatives 显示文摘 | MARCELINO L IGNACIO S | 2005 | Neurocomputing2005，69，13： | 1 |
| 6 | Heteroduplexes in mixed-template amplification: formation, consequence and elimination by 'reconditioning PCR'显示文摘 | Thompson J R Marcelino L A Polz M F | 2002 | Nucleic Acids Res2002，30，： | 1 |
| 7 | A constraint manager to support virtual maintainability显示文摘 | MARCELINO L MURRAY N FERNANDO T | 2003 | Computers & Graphics2003，27，1： | 1 |
| 8 | Support vector regression for the simultaneous learning of a multivariate function and its derivatives显示文摘 | MARCELINO L IGNACIO S | 2005 | Neurocomputing2005，69，13： | 1 |
| 9 | Diversity and dynamics of a North Atlantic coastal Vibrio community 显示文摘 | Thompson J R Randa M A Marcelino L A etal | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 10 | Heteroduplexes in mixed-template amplifications:formation,consequence and elimination by ‘econditioning PCR'显示文摘 | THOMPSON J R MARCELINO L A POLZ M F | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 11 | Heteroduplexes in mixed-template amplifications: formation, eonsequenee and elimination by ‘reconditioning PCR' 显示文摘 | THOMPSON J R MARCELINO L A POLZ M F | 2002 | Nueleic Acids Res2002，30，9： | 1 |
| 12 | Heteroduplexes in mixed-template amplifications:formation,consequence and elimination by 'reconditioning PCR'显示文摘 | THOMPSON J R MARCELINO L A POLZ M F | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 13 | Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by 'reconditioning PCR'显示文摘 | THOMPSON J R MARCELINO L A POLZ M F | 2002 | Nucleic Acids Research2002，30，： | 1 |
| 14 | Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by 'reconditioning PCIR' 显示文摘 | THOMPSON J R MARCELINO L A POLZ M F | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 15 | Heteroduplexes in mixed-template amplifications:formation,consequence and elimination by 'reconditioning PCR显示文摘 | THOMPSON J R MARCELINO L A POLZ M F | 2002 | Nucleic Acids Research2002，30，9： | 1 |
| 16 | Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by 'reconditioning PCR'显示文摘 | Thompson J R Marcelino L A Polz M F | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 17 | Heteroduplexes in mixed-template amplifications : Formation, consequence and elimination by reconditioning PCR 显示文摘 | Thompson J R Marcelino L A Polz M F | 2002 | Nucleic Acids Research2002，30，9： | 1 |
| 18 | Heterodu-plexes in mixed-template amplifications:formation,conse-quence and elimination b‘y reconditioning PCR显示文摘 | THOMPSON J R MARCELINO L A POLZ M F | 2002 | Nucleic AcidsResearch2002，30，9： | 1 |
| 19 | Antitrypanosomal alkaloids from the marine bacterium Bacillus pumilus 显示文摘 | Sergio M L Jos6 F G Marcelino C | 2012 | Molecules2012，17，11： | 1 |
| 20 | Hetereduplexes in mixed-template amplifications: formation, consequence and elimination by'reconditioning PCR' 显示文摘 | THOMPSON J R MARCELINO L A POLZ M F | 2002 | Nucleic Acids Res2002，30，9： | 1 |
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