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| 1 | Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer显示文摘AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS: Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin (TMβ), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexinⅠand an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 (HSP70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratinⅠ, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ,HSP70, annexinⅠ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION: Our study not only supports the involve- ment of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ. | Ferdous Rastgar Jazii Zahra Najafi Reza Malekzadeh Thomas P Conrads Abed Ali Ziaee Christian Abnet Mansour Yazdznbod Ali Asghar Karkhane Ghasem H Salekdeh | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | The imbalance in expres- sion of angiogenic and anti-angiogenic factors as candidate predic- tive biomarker in preeclampsia 显示文摘 | Nikuei P Malekzadeh K Rajaei M | 2015 | Iran J Reprod Med2015，13，5： | 1 |
| 3 | A differential quadrature nonlinear freevibration analysis of laminated composite skew thin plates 显示文摘 | Malekzadeh P | 2007 | Thin-Walled Structures2007，45，2： | 1 |
| 4 | Free vibration analysis of variable thickness thin and moderately thick plates with elastically restrained edges by DQM显示文摘 | MALEKZADEH P SHAHPARI S A | 2005 | Thin-Walled Structures2005，43，7： | 1 |
| 5 | Three-dimensional free vibration of laminated cylindrical panels with functionally graded layers显示文摘 | Malekzadeh P Ghaedsharaf M | 2014 | Composite Structures2014，108，： | 1 |
| 6 | Free vibration analysis of rotating functionally graded cylindrical shells in thermal environment 显示文摘 | MALEKZADEH P HEYDARPOUR Y | 2012 | Composite Structures2012，94，9： | 1 |
| 7 | Out-of-plane static analysis of circular arches by DQM 显示文摘 | Malekzadeh P Karami G | 2003 | International Journal of Solids and Structures2003，40，： | 1 |
| 8 | DQEM for free vibration analysis of Timoshenko beams on elastic foundations 显示文摘 | MALEKZADEH P KARAMI G | 2003 | Com- putational Mechanics2003，31，： | 1 |
| 9 | A mixed differential quad- rature and finite element free vibration and buckling analysis of thick beams on two-parameter elastic foundations显示文摘 | Malekzadeh P Karami G | 2008 | Applied Mathematical Modelling2008，32，7： | 1 |
| 10 | Buckling analysis of functionally graded arbitrary straight-sided quadrilateral plates on elastic foundations 显示文摘 | Malekzadeh P Haghighi M R Golbahar B A | 2012 | Meccani- ca2012，47，2： | 1 |
| 11 | DQEM for vibration analysis of Timoshenko beams on elastic foundations显示文摘 | Malekzadeh P Karami G Farid M | 2003 | Computational Mechanics2003，31，： | 1 |
| 12 | Optimization of convective-radiative fins by using diffierential quadrature element method 显示文摘 | P Malekzadeh H Rahideh G Karami | 2006 | Energy Convers Manage2006，47，1112： | 1 |
| 13 | A mixed differential quadrature and finite element free vibration and buckling analysis of thick beams on two-parameter elastic foundations显示文摘 | Malekzadeh P Karami G | 2008 | Applied Mathematical Modelling2008，32，7： | 1 |
| 14 | Three-Dimensional Free Vibration of Thick Functionally Graded Annular Plates in Thermal Environment 显示文摘 | MALEKZADEH P SHAHPARIC S A ZIAEED H R | 2010 | Journal of Sound and Vibration2010，329，： | 1 |
| 15 | Free vibration analysis of variable thickness thin and moderately thick plates with elastically restrained edges by DQM显示文摘 | Malekzadeh P Shahpari S A | 2005 | Thin-Walled Structures2005，43，7： | 1 |
| 16 | Optimization of convective-radiative fins using differential quadrature el- ement method 显示文摘 | Malekzadeh P Rahideh P Karami G | 2006 | Energy Conversion and Manage- ment2006，47，1112： | 1 |
| 17 | Large amplitude flexural vibration analysis of tapered plates with edges elastically restrained against rotation using DQM显示文摘 | Malekzadeh P Karami G | 2008 | Engineering Structures2008，30，10： | 1 |
| 18 | Three-dimensional temperature dependent free vibration analysis of functionally graded material curved panels resting on two-parameter elastic foundation using a hybrid semi-analytic,differential quadrature method显示文摘 | FARTD M ZAHEDINEJAD P MALEKZADEH P | 2010 | Materials and Design2010，31，1： | 1 |
| 19 | Vibration analy- sis of functionally graded thin-walled rotating blades under high tem- perature supersonic flow using the differential quadrature method 显示文摘 | Fazelzadeh S A Malekzadeh P Zahedinejad P | 2007 | Journal of Sound and Vibralion2007，306，1： | 1 |
| 20 | A semi-analytical DQEM for free vibration analysis of thick plates with two opposite edges simply supported 显示文摘 | Malekzadeh P Karami G Farid M | 2004 | Computer Methods in Applied Mechanics and Engineering2004，193，4547： | 1 |
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