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| 1 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 2 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 3 | A proteomic analysis of rice seedlings responding to 1,2,4-trichlorobenzene stress显示文摘回答 to1,2,4-trichlorobenzene (TCB ) 的根和叶子强调的米饭(Oryza sativa L.) 的 proteomic 分析被二维的胶化电气泳动执行,质量度谱(MS ) ,并且蛋白质数据库分析。结果证明 5 mg/L TCB 应力在米饭根和叶子在全球 proteome 上有重要效果。范畴的分析和 TCB 的功能强调可诱导的蛋白质证明回答的不同类型在米饭根和叶子被生产,当稻秧暴露于 5mg/L TCB 应力时。大多数回答为保卫 TCB 应力的损坏的米饭是必要的。这些回答包括有毒的物质,致病相关的蛋白质的表示,细胞壁物质的合成和第二等的混合物的解毒,蛋白质的规定和氨基酸新陈代谢,蛋氨酸的激活抢救小径,并且也包括渗透的规定和植物激素新陈代谢。比较 TCB 压力在二栽培变种,β-葡萄糖苷酶和致病相关的蛋白质之间的可诱导的蛋白质家庭 10 蛋白质被 TCB 应力特别地在米饭栽培变种( Oryza sativa L.)的根导致 Aizaizhan ,并且谷胱甘肽 S-transferase 和 aci-reductone dioxygenase 4 在米饭栽培变种 Shanyou 63 的根被导致。这可以是为比 Aizaizhan 有更高的公差到 TCB 应力的 Shanyou 63 的重要机制之一。 | GE Cailin WAN Dingzhen WANG Zegang DING Yan WANG Yulong SHANG Qi MA Fai LUO Shishi | 2008 | Journal of Environmental Sciences2008，20，3： | 7 |
| 4 | 厚板弯曲与拉伸振动精化理论及其求解新途径显示文摘利用弹性动力学中Boussinesq-Galerkin一般解,基于微分算子谱和算子代数理论,采用了适当的规范条件,建立了推演厚板结构动力学方程的新途径.首次给出了考虑横向荷载作用的平板弯曲和拉压振动的两类动力学方程具体形式.为推导动力学方程方便和利用微分算子谱分解理论,引进了虚微分算子(i)的概念.并将本文得到的平板结构振动方程与各种平板结构的弯曲方程作了对比分析.由于本文推导时没有采用任何工程假设,因此本文提出的平板动力学方程是精确的,可用于求解厚壁平板的振动和设计平板振动主动控制策略.本文为不采用几何方法,而是采用分析和代数的方法精确推导低维结构的动力学支配方程提供了一种统一规范的方法. | 胡超 MA Fai 马兴瑞 黄文虎 | 2012 | 中国科学:物理学、力学、天文学2012，42，5： | 6 |
| 5 | A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction显示文摘Hyperhomocysteinemia(HHcy)is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients.HHcy induces endoplasmic reticulum(ER)stress and oxidative stress to impair endothelial function.The glucagon-like peptide 1(GLP-1)analog exendin-4 attenuates endothelial ER stress,but the detailed vasoprotective mechanism remains elusive.The present study investigated the beneficial effects of exendin-4 against HHcy-induced endothelial dysfunction.Exendin-4 pretreatment reversed homocysteine-induced impairment of endothelium-dependent relaxations in C57BL/6 mouse aortae ex vivo.Four weeks subcutaneous injection of exendin-4 restored the impaired endothelial function in both aortae and mesenteric arteries isolated from mice with diet-induced HHcy.Exendin-4 treatment lowered superoxide anion accumulation in the mouse aortae both ex vivo and in vivo.Exendin-4 decreased the expression of ER stress markers(e.g.,ATF4,spliced XBP1,and phosphorylated eIF2α)in human umbilical vein endothelial cells(HUVECs),and this change was reversed by cotreatment with compound C(CC)(AMPK inhibitor).Exendin-4 induced phosphorylation of AMPK and endothelial nitric oxide synthase in HUVECs and arteries.Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase(ERO1α),an important ER chaperone in endothelial cells,and this effect was mediated by AMPK activation.Experiments using siRNA-mediated knockdown or adenoviral overexpression revealed that ERO1αmediated the inhibitory effects of exendin-4 on ER stress and superoxide anion production,thus ameliorating HHcy-induced endothelial dysfunction.The present results demonstrate that exendin-4 reduces HHcy-induced ER stress and improves endothelial function through AMPK-dependent ERO1αupregulation in endothelial cells and arteries.AMPK activation promotes the protein folding machinery in endothelial cells to suppress ER stress. | Chak Kwong Cheng Jiang-Yun Luo Chi Wai Lau William Chi-shing Cho Chi Fai Ng Ronald Ching Wan Ma Xiao Yu Tian Yu Huang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 6 |
| 6 | 基于平板振动精确化方程求解动应力集中问题显示文摘基于文献[8]给出的平板弯曲振动精确化方程,对含圆孔平板中弹性波散射与动应力集中问题进行了研究.文中给出了分别基于Mindlin板与精确化板方程在不同参数下圆孔动弯矩集中系数的数值结果,并对结果进行了对比分析和讨论.结果表明:在较低频率和薄板情况下,基于文献[8]的方程与基于Mindlin板理论得到的动弯矩结果是基本一致的;在较高频率和厚板情况下,基于文献[8]的方程与基于Mindlin板理论的动弯矩结果相差较大,最大值超出可达16%.由于文献[8]给出的平板振动精确化方程是在没有任何工程假设条件下得到的,因此其分析计算结果更精确一些. | 胡超 周传平 Fai Ma 刘殿魁 | 2012 | 力学学报2012，44，5： | 3 |
| 7 | Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy显示文摘 | Modrego PJ Fayed N Pina MA | 2005 | Am J Psychiatry2005，162，4： | 1 |
| 8 | Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy 显示文摘 | Modrego PJ Fayed N Pina MA | 2005 | Am J Psychiatry2005，162，4： | 1 |
| 9 | Changes in metabolite ratios after treatment with rivastigmine in Alzheimer's disease:a non-randomised controlled trial with magnetic resonance spectroacopy显示文摘 | Medrego PJ Pina MA Fayed N | 2006 | CNS Drugs2006，20，： | 1 |
| 10 | Conversion from mild cog- nitive impairment to probable Alzheimer's disease pre- dicted by brain magnetic resonance spectroscopy显示文摘 | Modrego PJ Fayed NPina MA | 2014 | Neu- rology2014，31，4： | 1 |
| 11 | Refined dynamic theory of thick plates in extension-bending and its new formulism 显示文摘 | Hu Chao Ma Fai Ma Xingrui Huang Wenhu | 2012 | Science China series G Physics Mechanics Astronomy2012，42，5： | 1 |
| 12 | Conversion from mild cognitive im- pairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy 显示文摘 | Modrego P J Fayed N Pina MA | 2005 | Am J Psychiatry2005，162，4： | 1 |
| 13 | Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy显示文摘 | Modrego PJ Fayed N Pina MA | 2005 | Am J Psychiatry2005，162，4： | 1 |
| 14 | Conversion from mild cognitive impairment to probable Alzheimer′s disease predicted by brain magnetic resonance spectroscopy显示文摘 | Modrego PJ Fayed N Pina MA | 2005 | Am J Psychiatry2005，162，4： | 1 |
| 15 | Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy显示文摘 | Modrego PJ Fayed N Pina MA | 2005 | Am J Psychiatry2005，162，： | 1 |
| 16 | Conversion from mild cog- nitive impairment to probable Alzheimer's disease pre dicted by brain magnetic resonance spectroscopy显示文摘 | Modrego PJ Fayed N Pina MA | 2014 | Biolog- ical psychiatry2014，68，15： | 1 |
| 17 | The decoupling of damped linear systems in oscillatory free vibration 显示文摘 | Fai Ma Ali Imam Matthias morzfeld | 2009 | Journal of Sound and Vibration2009，324，： | 1 |
| 18 | Clone detection via structureabstraction显示文摘 | EVANS W S FRASER C W MA Fai | 2009 | Software Quality Journal2009，17，4： | 1 |
| 19 | Changes in metabolite ratios after treatment with rivastigmine in patients with Alzheimer's disease:a nonrandomised controlled trial with proton magnetic resonance spectroscopy显示文摘 | Modrego PJ Pina MA Fayed N | | 0，，10： | 1 |
| 20 | Titanium surface topography after brushing with fluoride and fluoridefree toothpaste simulating 10 years of use显示文摘 | Fais LM Fernandes-Filho RB Pereira-da-Silva MA | 2012 | J Dent2012，40，4： | 1 |
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