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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Loss of p53 accelerates neointimal lesions of vein bypass grafts in mice显示文摘 | Mayr U Mayr M Li CH Wernig F Dietrich H Hu Y | 2002 | Circ Res2002，90，2： | 1 |
| 3 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state显示文摘 | Wernig M Meissner A Foreman R | 2007 | Nature2007，448，7151： | 1 |
| 4 | Muscle satellite (stem) cell activation during local tissue injury and repair显示文摘 | Hill M Wernig A Goldspink G | | 0，，01： | 1 |
| 5 | Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells显示文摘 | Meissner A M Wernig | 2007 | Nat Biotech2007，25，10： | 1 |
| 6 | In vitro differentiation of transplantable neural precursors from human embryonic stem cells 显示文摘 | Zhang SC Wernig M Duncan ID | 2001 | Nat Biotechnol2001，19，： | 1 |
| 7 | Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells显示文摘 | Meissner A Wernig M Jaeniscb R | 2007 | Nat Biotechnol2007，25，10： | 1 |
| 8 | e-Myc is dispensable for direct reprogramming of mouse fibroblasts 显示文摘 | Wernig M Meissner A Cassady JP | 2008 | Cell Stem Cell2008，2，： | 1 |
| 9 | Muscle satellite (stem) cell, activation during local tissue injury and repair显示文摘 | Hill M Wernig A Goldspink G | 2003 | J Anat2003，203，1： | 1 |
| 10 | In vitro differentiation of transplantable neural precursors from human embryonic stem cells显示文摘 | Wernig M Duncan ID | 2001 | Nat Biotechnol2001，19，12： | 1 |
| 11 | Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson′s disease显示文摘 | Wernig M Zhao JP Pruszak J | 2008 | Proc Natl Acad Sci USA2008，105，15： | 1 |
| 12 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state显示文摘 | Wernig M Meissner A Foreman R | 2007 | Nature2007，448，7151： | 1 |
| 13 | Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin显示文摘 | Hanna J Wernig M Markoulaki S | 2007 | Science2007，318，5858： | 1 |
| 14 | Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin显示文摘 | Hanna J Wernig M Markoulaki S | 2007 | Science2007，318，5858： | 1 |
| 15 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state显示文摘 | Wernig M Meissner A Foreman R | 2007 | Nature2007，448，7151： | 1 |
| 16 | Mechanical stress-activated PKC delta regulates smooth muscle cell migration 显示文摘 | Li C Wernig F Leitges M | 2003 | FASEB J2003，17，14： | 1 |
| 17 | Direct conversion of fibroblasts to functional neurons by defined factors显示文摘 | Vierbuchen T Ostermeier A Pang Z P Kokubu Y Siidhof T C Wernig M | | 0，，7284： | 1 |
| 18 | Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease显示文摘 | Wernig M Zhao JP Pruszak J | 2008 | Proc Natl Acad Sci USA2008，105，15： | 1 |
| 19 | In vitro differentiation of transplantable neural precursors from human embryonic stem cells显示文摘 | Zhang SC Wernig M Duncan ID | | 0，，： | 1 |
| 20 | Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin显示文摘 | H anna J Wernig M Markoulaki S | 2007 | Sience2007，318，： | 1 |
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