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| 1 | Hot deformation of Mg-Y-Zn alloy with a low content of the LPSO phase studied by in-situ synchrotron radiation diffraction显示文摘The compressive deformation behavior of the extruded WZ42(Mg98.5Y1Zn0.5 in at.%)magnesium alloy containing a low amount of long-period stacking ordered(LPSO)phase was studied by in-situ synchrotron radiation diffraction technique.Tests were conducted at temperatures between room temperature and 350℃.Detailed microstructure investigation was provided by scanning electron microscopy,particularly the backscattered electron imaging and electron backscatter diffraction technique.The results show that twinning lost its dominance and kinking of the LPSO phase became more pronounced with increasing deformation temperature.No cracks of the LPSO phase and no debonding r at the interface between the LPSO phase and the Mg matrix were observed at temperatures above 200℃.At 350℃,the LPSO phase lost its strengthening effect and the deformation of the alloy was mainly realized by the dynamic recrystallization of the Mg matrix. | Klaudia Horváth Fekete Daria Drozdenko Jan Capek Kristián Máthis Domonkos Tolnai Andreas Stark Gerardo Garcés Patrik Dobron | 2020 | Journal of Magnesium and Alloys2020，8，1： | 5 |
| 2 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 3 | Validity of the visual analogue scale as an instrument to measure self‐efficacy in resuscitation skills显示文摘 | Nigel MTurner Anita JVan De Leemput Jos M TDraaisma PaulOosterveld Olle Th JTen Cate | 2008 | Medical Education2008，，5： | 4 |
| 4 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 5 | SOURCE RADIATION AND RESPONSES OF WAVE PROPAGATION显示文摘Recordings of seismic waves propagating from earthquake source to a station at the earth’s surface are a system response function. The convolution operator in time domain can be simplified as a multiplication operator in frequency domain. We discuss in frequency domain the separation of source, path and site effects for global scaling of earthquake source radiation. Also discussed are source scaling model, faulting mechanism, and the H/V inversion problems with crustal and near surface structures. Gross features of apparent source spectra appear to be not much region dependent although there may be difference between tectonic styles within a region of tectonic mixture for which we need further study as data accumulate. Vertical spectra may be a better approach to approximate source radiation, as it has less crustal amplification effects than horizontal spectra. The H/V ratio is evidently a comprehensive indicator of amplification effects from near surface to deep structure. This gives it potential as an inversion tool to deduce site crustal structure. | CHEN Sheng zao 1 and Gail M Atkinson 2 (1. Geomatrix Consultants, Inc., 2101 Webster St., 12 th Floor, Oakland, CA 94612, USA, formerly at Dept. Earth Sciences & Ottawa Carleton Geoscience Center, Carleton University, Ottawa, Canada 2. Dept. Ea | 2001 | Geotectonica et Metallogenia2001，25，1： | 2 |
| 6 | Filamentation “remote” sensing of chemical and biological agents/pollutants using only one femtosecond laser source显示文摘 | S. L. Chin H. L. Xu Q. Luo F. Théberge W. Liu J. F. Daigle Y. Kamali P. T. Simard J. Bernhardt S. A. Hosseini M. Sharifi G. Méjean A. Azarm C. Marceau O. Kosareva V. P. Kandidov N. Ak?zbek A. Becker G. Roy P. Mathieu J. R. Simard M. Chateauneuf J. Dubois | 2009 | Applied Physics B2009，，1： | 2 |
| 7 | Two-site/two-region models for pesticide transport and degradation: theoretical development and analytical solutions 显示文摘 | Van Genuchten M Th Wagenet R J | 1989 | Soil Science Society of America journal1989，53，5： | 2 |
| 8 | The evolution of microstructure in a laser clad TiB-Ti composite coating 显示文摘 | KOOI B J PEI Y T DE HOSSON J Th M | 2003 | Acta Mater2003，51，2： | 2 |
| 9 | Influences and consequences for anxiolytic premedication 显示文摘 | Schneider-Bandura M Vormann Th Fisher M Fear of outpatient gastroscopy | 1993 | Dtsch Med Wochenschr1993，135，： | 1 |
| 10 | Effects of dietary xylitol on collagen content and glycosylation in healthy and diabetic rats显示文摘 | Knuuttila M Kuoksa TH Svanberg M | 2000 | Life Sci2000，67，3： | 1 |
| 11 | Determination of resistance to Fusarium oxysporium in Lilium显示文摘 | straathof Th P Jansen J Loftier H J M | 1993 | Phytopathology1993，83，5： | 1 |
| 12 | MUC16 (CA125) regulates epithelial ovarian cancer cell growth,tumorigenesis and metastasis显示文摘 | Thériault C Pinard M Comamala M | 2011 | Gynecol Oncol2011，121，3： | 1 |
| 13 | On the stability of the linear mapping in Banach spaces 显示文摘 | Rassias Th M | 1978 | Proc Amer Math Soc1978，72，2： | 1 |
| 14 | Attosec ond control of electronic processes by intense light fields 显示文摘 | A Baltugka Th Udem M Uiberacker | 2003 | Nature2003，421，6923： | 1 |
| 15 | Grinding of WC - Co hardmetals显示文摘 | HEGEMANJBJ W DE HOSSONJ Th M DE With G | 2001 | Wear2001，，248： | 1 |
| 16 | Temporal age-relat ed changes in spectral, fractal and complexity characteristics of heart rate variability显示文摘 | Jokinen V Syvanne M Makikallio TH | 2001 | Clin Physiol2001，21，3： | 1 |
| 17 | A closed-form equation for predicting the hydraulic conductivity of unsaturated soils显示文摘 | van Genuchten M Th | 1980 | Soil Science Society of America Journal1980，44，5： | 1 |
| 18 | Rosetta: A com- puter program for estimating soil hydraulic parameters with hierar- chical pedotransfer functions 显示文摘 | Schaap M G Leij F J Van Genuchten M Th | 2001 | Journal of Hydrology2001，251，34： | 1 |
| 19 | Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation显示文摘 | Hllttemann M Helling S Sanderson TH | 2012 | Biochim Biophys Acta2012，1817，： | 1 |
| 20 | Growth-differentiation factor-15:a novel biomarker in patients with diastolic dysfunction?显示文摘 | Dinh W Füth R Lankisch M | 2011 | Arq Bras Cardiol2011，97，1： | 1 |
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