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| 1 | CoolClot,a novel hemostatic agent for controlling life-threatening arterial bleeding显示文摘BACKGROUND:Uncontrolled bleeding is the first leading cause of preventable death in the battlefield and the 2nd cause of mortality in civil accidents.Incompressible hemorrhage control is among the interventions that drastically increase the survival rate in wound individuals.We have previously shown that a certain mixture of bentonite and zeolite minerals can significantly decrease the bleeding in rats.METHODS:In this study,nine healthy hybrid dogs were selected and after induction of anesthesia with ether,either arterial puncture by a needle or arteriotomy was performed on both groin regions of the dogs.For control arteries(either the right or left femoral artery),only pressure by sterilized gauze was performed,while for the femoral arteries of the opposite side,our invented hemostatic agent,namely CoolClot,was topically used before applying the pressure.In the second stage of the study,to assess the coagulation time,blood samples were collected from 10 volunteer students.RESULTS:CoolClot significantly decreased the bleeding time in animals whose femoral arteries were cut or punctured.In the human phase of the study,the mean coagulation time in control blood samples was 253.4+44.1 seconds,whereas it was 149.5+50.0,162.3±74.6 and 143.4±114.6seconds,respectively in blood samples treated with bentonite,zeolite and CoolClot(P<0.05).CONCLUSIONS:As controlling bleeding after a life-threatening arterial damage is critical for increasing the chance of survival,the results obtained in this study indicate the significant efficacy of CoolClot in shortening the bleeding time.Our experiments also indicate that CoolClot can significantly reduce the clotting time in human blood samples. | SMJ Mortazavi A Tavasoli M Atefi N Tanide N Radpey P Roshan-shomal H Moradi S Taeb | 2013 | World Journal of Emergency Medicine2013，4，2： | 2 |
| 2 | Ontologies to Support Process In- tegration in Enterprise Engineering显示文摘 | Gruninger M Atefi K Fox M S | 2000 | Computational and Mathe- matical Organization Theory2000，6，4： | 1 |
| 3 | Ontologies to support process integration in enterprise engineering显示文摘 | GRUNINGER M ATEFI K FOX M S | 2000 | Computational and Mathe-matical Organization Theory2000，6，4： | 1 |
| 4 | Effects of MAPK and PDK pathways on PD-L1 expression in melanoma显示文摘 | Atefi M Avramis E Lassen A | 2014 | Clin Cancer Res2014，20，13： | 1 |
| 5 | The pattern of mobile phone use and prevalence of self-reported symptoms in elementary and junior high school students in shiraz, iran 显示文摘 | Mortazavi SM Atefi M Kholghi F | 2011 | Iran J Med Sci2011，36，2： | 1 |
| 6 | Ontologies to Support Process Integration in Enterprise Engineering显示文摘 | Gruninger M Atefi K Fox Ms | 2001 | Computational and Mathematical Organization Theory2001，6，4： | 1 |
| 7 | Ontologies to support process integration in enterprise engineering显示文摘 | GRUNINGER M ATEFI K FOX M S | 2001 | Computational and Mathematical Organization Theory2001，6，4： | 1 |
| 8 | Should routine echocardiography be performed in all patients with stroke显示文摘 | Wolber T Maeder M Atefy R | 2007 | J Stroke Cerebrovasc Dis2007，16，1： | 1 |
| 9 | Effect of stain- ing procedures on the results of micronueleus assays with exfoliated oral mucosa cells显示文摘 | Nersesyan A Kundi M Atefie K | 2006 | Cancer Epidemiol Biomar-- kers Prey2006，15，10： | 1 |
| 10 | Non-Fourier Temperature Field in a Solid Homogeneous Finite Hollow Cylinder 显示文摘 | Atefi G Talaee M R | 2011 | Archive of Applied Mechanics2011，81，5： | 1 |
| 11 | Ontologies to Support Process Integration in Enterprise Engineering显示文摘 | GRUNINGER M ATEFI K FOX MS | 2000 | Computational and Mathematical Organization Theory2000，6，4： | 1 |
| 12 | Non-Fourier temperature field in a solid homogeneous finite hollow cylinder显示文摘 | ATEFI G TALAEE M R | | 0，，5： | 1 |
| 13 | Effects of MAPK and PI3K pathways on PD-LI expression in melanoma显示文摘 | Atefi M Avramis E Lassen A | 2014 | Clin Cancer Res2014，20，13： | 1 |
| 14 | Ontologies to support process integra- tion in enterprise engineering显示文摘 | Gruninger M Atefi K Fox M S | 2000 | Computational and Mathematical Or- ganization Theory2000，6，4： | 1 |
| 15 | Antitumor effects of the investlgational selective MEK inhibitor TAK733 against cuta- neous and uveal melanoma cell lines显示文摘 | VON EUW E ATEFI M ATTAR N | 2012 | Mol Cancer2012，11，： | 1 |
| 16 | Ontologies to Support Process Integration in Enterprise Engineering显示文摘 | Gruninger M Atefi K Fox M S | 2000 | Computational & Mathematical Organization Theory2000，，6： | 1 |
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