|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multidisciplinary management of gastric and gastroesophageal cancers显示文摘Carcinomas of the stomach and gastroesophageal junction are among the fi ve top leading cancer types worldwide. In spite of radical surgical R0 resections being the basis of cure of gastric cancer,surgery alone provides long-term survival in only 30% of patients with advanced International Union Against Cancer (UICC) stages in Western countries because of the high risk of recurrence and metachronous metastases. However,recent large phase-Ⅲ Studies improved the diagnostic and therapeutic options in gastric cancers,indicating a more multidisciplinary management of the disease. Multimodal strategies combining dif-ferent neoadjuvant and/or adjuvant protocols have clearly improved the gastric cancer prognosis when combined with surgery with curative intention. In particular,the perioperative (neoadjuvant,adjuvant) chemotherapy is now a well-established new standard of care for advanced tumors. Adjuvant therapy alone should be carefully discussed after surgical resection,mainly in individual patients with large lymph node positive tumors when neoadjuvant therapy could not be done. The palliative treatment options have also been remarkably improved with new chemotherapeutic agents and will further be enhanced with targeted therapies such as different monoclonal antibodies. This article reviews the most relevant literature on the multidisciplinary management of gastric and gastro-esophageal cancer,and discusses future strategies toimprove locoregional failures. | Markus Moehler Orestis Lyros Ines Gockel Peter R Galle Hauke Lang | 2008 | World Journal of Gastroenterology2008，14，24： | 17 |
| 2 | LINX^(■) reflux management system to bridge the “treatment gap” in gastroesophageal reflux disease: A systematic review of 35 studies显示文摘BACKGROUND Gastroesophageal reflux disease(GERD) occurs when the reflux of stomach contents causes troublesome symptoms and/or complications. When medical therapy is insufficient, surgical therapy is indicated and, until now, Laparoscopic fundoplication(LF) constitutes the gold-standard method. However, magnetic sphincter augmentation(MSA) using the LINX^® Reflux Management System has recently emerged and disputes the standard therapeutic approach.AIM To investigate the device’s safety and efficacy in resolving GERD symptoms.METHODS This is a systematic review conducted in accordance to the PRISMA guidelines.We searched MEDLINE, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL databases from inception until September 2019.RESULTS Overall, 35 studies with a total number of 2511 MSA patients were included and analyzed. Post-operative proton-pump inhibitor(PPI) cessation rates reached 100%, with less bloating symptoms and a better ability to belch or vomit in comparison to LF. Special patient groups(e.g., bariatric or large hiatal-hernias)had promising results too. The most common postoperative complication was dysphagia ranging between 6% and 83%. Dilation due to dysphagia occurred in 8% of patients with typical inclusion criteria. Esophageal erosion may occur in up to 0.03% of patients. Furthermore, a recent trial indicated MSA as an efficient alternative to double-dose PPIs in moderate-to-severe GERD.CONCLUSION The findings of our review suggest that MSA has the potential to bridge the treatment gap between maxed-out medical treatment and LF. However, further studies with longer follow-up are needed for a better elucidation of these results. | Dimitrios Schizas Aikaterini Mastoraki Eleni Papoutsi Vassilis G Giannakoulis Prodromos Kanavidis Diamantis Tsilimigras Dimitrios Ntourakis Orestis Lyros Theodore Liakakos Dimitrios Moris | 2020 | World Journal of Clinical Cases2020，8，2： | 3 |
| 3 | Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells显示文摘 | Medda R Lyros O Schmidt JL | 2015 | Microvasc Res2015，，97： | 1 |
| 4 | Wnt/13-Catenin Signaling Activation be- yond Robust Nuclear 3-Catenin Accumulation in Nondysplastic Bar- rett's Esophagus: Regulation via Dickkopf-l显示文摘 | Lyros O Rafiee P Nie L | 2015 | Neoplasia2015，17，7： | 1 |
| 5 | Dissection of lymph node metastases in esophageal cancer显示文摘 | Gockel I Sgourakis G Lyros O | 2011 | Expert Rev Anti- cancer Ther2011，11，4： | 1 |
| 6 | Analysis of anti - pro?liferative and chemo - sensitizing effects of sunitinib on hu?man esophageal - gastric cancer cells: Synergistic interac?tion with vandetanib via inhibition of muti - receptor tyro?sine kinase pathways显示文摘 | Lyros 0 Mueller A Heidel F | 2010 | Int J Cancer2010，127，5： | 1 |
| 7 | Analysis of anti-proliferative and chemosensitizing effects of sunitinib on human esophagogastric cancer cells:synergistic interaction with vandetanib via inhibition of multi-receptor tyrosine kinase pathways显示文摘 | Lyros O Mueller A Heidel F | | 0，，5： | 1 |
| 8 | Dissection of lymph node metastases in esophageal cancer 显示文摘 | Gockel I Sgourakis G Lyros O | 2011 | Expert Rev Anticancer Ther2011，11，4： | 1 |
| 9 | Molecular links between endothelial dysfunction and neurodegeneration in Alzheimer's disease显示文摘 | Lyros E Bakogiannis C Liu Y | 2014 | Curr Alzheimer Res2014，11，1： | 1 |
| 10 | Dissection of lymph node metastases in esophageal cancer显示文摘 | Gockel I Sgourakis G Lyros O | 2011 | Expert Rev Anticancer Ther2011，11，4： | 1 |
| 11 | Diekkopf-1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis 显示文摘 | Lyros O Rafiee P Nie L | 2014 | Am J Physiol Gastrointest Liver Physio12014，306，7： | 1 |
| 12 | Risk of lymph node metastasis in submucosal esophageal cancer:a review of surgically resected patients显示文摘 | Gockel I Sgourakis G Lyros O | 2011 | Expert Rev Gastroenterol Hepatol2011，5，3： | 1 |
| 13 | Wnt/β-catenln signaling activation beyond robust nuclear β-catenin accumulation in nondysplastic Bar- rett's esophagus: regulation via dickkopf-1 显示文摘 | Lyros O Rafiee P Nie L | 2015 | Neoplasia2015，7，： | 1 |
| 14 | Anti inflammatory and anti anglo- genie effect of black raspberry extract on human esophageal and intesti- nal microvascular endothelial cells 显示文摘 | Medda R Lyros O Schmidt JL | 2015 | Microvasc Res2015，97，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员