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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Experimental study of bimolecular reaction in Poiseuille flow显示文摘 | Kapoor V Jafvert C T Lyn D A | | 0，，08： | 1 |
| 3 | The 894T allele of endothelial nitric oxide synthase gene is related to left ventricular mass in African Americans with high-normal blood pressure 显示文摘 | Lapu-Bula R Quarshie A Lyn D | 2005 | J Natl Med Assoc2005，97，2： | 1 |
| 4 | density currents and shear-induced flocculation in sedimentation tanks显示文摘 | STAMOU A I RODI W | | Journal of Hydraulic Engineering0，，： | 1 |
| 5 | Quantified small-scale turbulence inhihits the growth of a green alga显示文摘 | HONDZO M LYN D | 1999 | Freshwater Biology1999，41，1： | 1 |
| 6 | Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer显示文摘 | Araki S Omori Y Lyn D | 2007 | Cancer Res2007，67，14： | 1 |
| 7 | Quantified small-scale turbulence inhibits thegrowth of a green alga 显示文摘 | Hondzo M Lyn D | 1999 | Freshwater Biology1999，41，1： | 1 |
| 8 | Children's Problem Posing within Formal and Informal Contexts 显示文摘 | Lyn D English | 1998 | Journal for Research in Math- ematics Education1998，29，1： | 1 |
| 9 | Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function,and blood pressure in African Americans显示文摘 | Li R Lyn D Lapu-Bula R | 2004 | Am J Hypertens2004，17，7： | 1 |
| 10 | Nonalcoholic fatty liver disease:relationship to insulin sensitivity and oxidative stress显示文摘 | Lyn Patrick N D | 2002 | Altem Med Rev2002，7，4： | 1 |
| 11 | Turbulence measurements in open channel flows over artificial bed forms 显示文摘 | Lyn D A | 1993 | Journal of Hydraulic Engineering ASCE1993，199，3： | 1 |
| 12 | Interleukin-8 is a molecular determinant of androgen independence and pro- gression in prostate cancer 显示文摘 | ARAKI S OMORI Y LYN D | 2007 | Cancer Research2007，67，14： | 1 |
| 13 | A duplicated region is responsible for the poly (ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer 显示文摘 | Lyn D Cherny BW Lalande M | 1993 | Am J Hum Genet1993，52，1： | 1 |
| 14 | Universal reaction-limited colloid aggregation显示文摘 | Lyn M Y Lindsay H M Weitz D A | 1990 | Phys RevA1990，41，： | 1 |
| 15 | Density currents and shear-induced flocculation in sedimentation tanks 显示文摘 | Lyn D A Stamou A I Rodi W | 1992 | Journal of Hydraulic Engineering1992，118，6： | 1 |
| 16 | Density currents and shearinduced flocculation in sedimentation tanks显示文摘 | Lyn D A Stamou A I Rodi W | 1992 | Journal of Hydraulic Engineering1992，118，6： | 1 |
| 17 | The 894T allele of endothelial nitric oxide synthase gene is related to left ventricular mass in African Americans with highnormal blood pressure 显示文摘 | Lapu-Bula R Quarshie A Lyn D | 2005 | J Natl Med Assoc2005，97，2： | 1 |
| 18 | Interleukin-8 is a molecular deter- minant of androgen independence and progression in prostate cancer显示文摘 | Araki S Omori Y Lyn D | 2007 | Cancer Res2007，67，14： | 1 |
| 19 | A Modeling Perspective on Students' Mathematical Reasoning about Data 显示文摘 | Helen M Doerr Lyn D English | 2003 | Journal for Research in Mathematics Education2003，34，2： | 1 |
| 20 | Density currents and shearinduced flocculation in sedimentation tanks显示文摘 | Lyn D A Stamou A I Rodi W | 1992 | J Hydr Engrg ASCE1992，118，6： | 1 |
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