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| 1 | Brain Metastases Treated with Radio surgery Alone:An Alternative to Whole Brain Radiotherapy?显示文摘OBJECTIVE:Whole brain radiotherapy(WBRT)provides benefit for patients with b rain metastases but may result in neurological toxicity for patien ts with extended survival times.Ste reotactic radiosurgery in combination with WBRT has become an important approach,but the value of WBRT has been questioned.As an alternative to WBRT,we managed patients with stereotactic radiosurgery alone,evaluated pati ents’outcomes,and assessed prognostic factors for survival and tumor c ontrol.METHODS:One hundred seventy-two patients with b rain metastases were managed with ra diosurgery alone.One hundred twent y-one patients were evaluable with follow-up imaging after radiosurgery.The median patien t age was 60.5years(age range,16-86yr).The mean marginal tumor dose and volume were 18.5Gy (range,11-22Gy )and 4.4ml (range,0.1-24.9ml ).Eighty percent of patients had soli tary tumors.RESULTS:The overall median survival time was8months.The median survival time in patients with no evidence of primary tumor disease or stable disease was 13and 11months.The local tumor contr ol rate was 87%.At 2years,the rate of local control,remote brain control,and total intr acranial control were 75%,41%,and 27%,respectively.In multivariate a nalysis,advanced primary tumor status(P=0.0003),older age(P=0.008),lower Karnofsky Performance Scale score(P=0.01),and malignant melanoma (P=0.005)were significant for poorer surviva l.The median survival time was 28mon ths for patients younger than 60years of age,with Karnofsky Performance Scale score o f at least 90,and whose primary tumor status showed either no evidence of disease or stable disease.Tumor volume (P=0.02)alone was significant for local tumo r control,whereas no factor affecte d remote or intracranial tumor contr ol.Eleven patients developed complica tions,six of which were persistent.Nineteen(16.5%)of 116patients in whom the cause of death was obtained died as a result of cause s related to brain metastasis.CONCLUSION:Brain metastases were controlled we ll with radiosurgery alone as initial thera py.We advocate that WBRT should not be part of the initial treatment proto col for selected patients with one or two tumors with good control of their primary cancer,better Karnofsky Performance Scale score,and you nger age,all of which are predictors of longer | Toshinori Hasegawa Douglas Kondziolka John C.Flickinger Anand Germanwala L.Dade Lunsford | 2003 | 癌症2003，22，7： | 23 |
| 2 | Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study显示文摘We evaluated the efficacy and safety of gamma knife stereotactic radiosurgery(GKSR)followed by bevacizumab combined withchemotherapy in 11 patients with recurrent glioblastoma multiforme who experienced tumor progression despite aggressive | Park KJ Kano H Iyer A Liu X Niranjan A Flickinger JC Lieberman FS Lunsford LD Kondziolka D | 2012 | 中国神经肿瘤杂志2012，10，4： | 3 |
| 3 | Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation显示文摘Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients. | Keri E Lunsford Adam S Bodzin Diego C Reino Hanlin L Wang Ronald W Busuttil | 2016 | World Journal of Gastroenterology2016，22，45： | 3 |
| 4 | Steady-state conversion of methane to C4+ aliphatic products in high yields using an integrated recycle reactor system显示文摘 | Pak S Rades T Rosynek M P Lunsford J H | | 0，，： | 2 |
| 5 | Perceived ethics of online retailers and consumer behavioral intentions: The mediating roles of trust and attitude显示文摘 | Yam B. Limbu Marco Wolf Dale Lunsford | 2012 | Journal of Research in Interactive Marketing2012，，2： | 2 |
| 6 | Consumers’ perceptions of online ethics and its effects on satisfaction and loyalty显示文摘 | Yam B. Limbu Marco Wolf Dale L. Lunsford | 2011 | Journal of Research in Interactive Marketing2011，，1： | 2 |
| 7 | Repeat Gamma Knife Radiosurgery for Trigeminal Neuralgia显示文摘 | Kyung-Jae Park Douglas Kondziolka Oren Berkowitz Hideyuki Kano Josef Novotny Ajay Niranjan John C. Flickinger L. Dade Lunsford | 2012 | Neurosurgery2012，，2： | 2 |
| 8 | Two methods for quantifying DNA extracted from poly ( lactideco-glycolide ) microspheres 显示文摘 | Barman S P Lunsford L Chambers P | 2000 | J Controlled Release2000，69，： | 1 |
| 9 | The catalytic oxidative coupling of methane显示文摘 | Lunsford J H | 1995 | Angew Chem Int Edition in English1995，34，9： | 1 |
| 10 | A multiinstitutional experience with stereotactic radiosurgery for solitary brain metastasis 显示文摘 | Flickinger JC Kondziolka D Lunsford LD | 1994 | Iht J Radiat Oncol Biol Phy1994，28，： | 1 |
| 11 | The natural history of cerebral cavemous malformations显示文摘 | Konziolka D Lunsford LD Kesle JR | 1995 | J Neurosurg1995，831，5： | 1 |
| 12 | Radiosurgery for hemangiomas of the cavernous sinus and orbit: technical case report 显示文摘 | THOMPSON T P LUNSFORD L D FLICKINGER J C | 2000 | Neurosurgery2000，47，3： | 1 |
| 13 | Using scoring rubrics to evaluate inquiry显示文摘 | Lunsford E Claudia T M | | 0，，01： | 1 |
| 14 | The effect of sodium poisoning on dealuminated Y-type zeolites显示文摘 | FRITZ P O LUNSFORD J H | 1989 | Journal of Catalysis1989，118，1： | 1 |
| 15 | The application of stereotactic radiosurgery to disorders of the brain显示文摘 | Kondziolka D Lunsford LD Flickinger JC | 2008 | Neurosurgery2008，62，2： | 1 |
| 16 | Stereotactic Radiosurgery for Trigeminal Neuralgia:A Mutti-Institutional Study the Gamma Knife显示文摘 | Kondziolka D Lunsford LD Flickinger JC | 1996 | Neurosary1996，84，6： | 1 |
| 17 | Recent advances in the oxidative coupling of methane显示文摘 | Lunsford J H | 1994 | Stud Surf Sci Catal1994，81，： | 1 |
| 18 | Skeletal isomerization of hexane over Pt/H-beta zeolite:Is the classical mechanism correct显示文摘 | CHU H Y ROSYNEK M P LUNSFORD J H | 1998 | J Catal1998，178，1： | 1 |
| 19 | Stereotacticradiosurgery of meningiomas 显示文摘 | Kondziolka D Lunsford LD Coffey RJ? | 1991 | J Neurosurg1991，74，： | 1 |
| 20 | The srhSR gene pair from staphylococcus aurens: genomic and proteomic approaches to the identification and characterization of gene function显示文摘 | Throup JP Zappacosta F Lunsford RD | 2001 | Biochemistry2001，40，10： | 1 |
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