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| 1 | Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis显示文摘In the present study we explored the different patterns of volumetric atrophy in hippocampal subregions of patients with left and right mesial temporal lobe epilepsy with hippocampal sclerosis(TLE-HS). Meanwhile, the memory impairment patterns in Chinese-speaking TLE-HS patients and potential influencing factors were also determined. TLE-HS patients(21 left and 17 right) and 21 healthy controls were recruited to complete T2-weighted imaging and verbal/nonverbal memory assessment. The results showed that both left and right TLE-HS patients had overall reduced hippocampal subregion volumes on the sclerotic side, and cornu ammonis sectors(CA1) exhibited maximum atrophy. The verbal memory of left TLE-HS patients was significantly impaired(P \ 0.001) and was not associated with the volumes of the left hippocampal subregions. Verbal or nonverbal memory impairment was not found in the patients with right TLE-HS. These results suggested that the atrophy of hippocampal subregion volumes cannot account for the verbal memory impairment, which might be related to the functional network. | Caihong Ji Lujia Zhu Cong Chen Shuang Wang Leilei Zheng Hong Li | 2018 | Neuroscience Bulletin2018，34，2： | 4 |
| 2 | Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach显示文摘Dear Editor,Hepatoid adenocarcinoma(HAC)is a rare pathological subtype of extrahepatic tumor,featured by hepatoid differentiation andα-fetoprotein(AFP)-production[1,2].Hepatoid adenocarcinoma of the stomach(HAS),accounting for 0.3%to 1.0%of all gastric cancers(GCs),has attracted increasing attention due to its high degree of malignancy[3].Compared with classic GC,HAS showed a higher rate of vascular invasion,lymph node metastasis,and liver metastasis,with only 9.0%survival rate at 5 years[4].Currently,there is no effective treatment for HAS,and little is known about its pathogenesis.Herein,we investigated the molecular features of HAS and identified potential therapeutic targets for HAS. | Mengxuan Zhu Erbao Chen Shan Yu Chen Xu Yiyi Yu Xin Cao Wei Li Pengfei Zhang Yan Wang Baofeng Lian Shuirong Zhang Yueting Qu Lujia Huang Weiwei Shi Yuehong Cui Li Qian Tianshu Liu | 2022 | Cancer Communications2022，42，10： | 3 |
| 3 | Comparison and rapid prediction of lignocellulose and organic elements of a wide variety of rice straw based on near infrared spectroscopy显示文摘Rice straw is a major kind of biomass that can be utilized as lignocellulosic materials and renewable energy.Rapid prediction of the lignocellulose(cellulose,hemicellulose,and lignin)and organic elements(carbon,hydrogen,nitrogen,and sulfur)of rice straw would help to decipher its growth mechanisms and thereby improve its sustainable usages.In this study,364 rice straw samples featuring different rice subspecies(japonica and indica),growing seasons(early-,middle-,and late-season),and growing environments(irrigated and rainfed)were collected,the differences among which were examined by multivariate analysis of variance.Statistic results showed that the cellulose content exhibited significant differences among different growing seasons at a significant level(p<0.01),and the contents of cellulose and nitrogen had significant differences between different growing environments(p<0.01).Near infrared reflectance spectroscopy(NIRS)models for predicting the lignocellulosic and organic elements were developed based on two algorithms including partial least squares(PLS)and competitive adaptive reweighted sampling-partial least squares(CARS-PLS).Modeling results showed that most CARS-PLS models are of higher accuracy than the PLS models,possibly because the CARS-PLS models selected optimal combinations of wavenumbers,which might have enhanced the signal of chemical bonds and thereby improved the predictive efficiency.As a major contributor to the applications of rice straw,the nitrogen content was predicted precisely by the CARS-PLS model.Generally,the CARS-PLS models efficiently quantified the lignocellulose and organic elements of a wide variety of rice straw.The acceptable accuracy of the models allowed their practical applications. | Abdoulaye Aguibou Diallo Zengling Yang Guanghui Shen Jinyi Ge Zichao Li Lujia Han | 2019 | International Journal of Agricultural and Biological Engineering2019，12，2： | 2 |
| 4 | Toripalimab in advanced biliary tract cancer显示文摘Gemcitabine combined with platinum/fluorouracil drugs is the standard firstline treatment for advanced biliary tract cancers(BTCs).We explored the safety and efficacy of toripalimab plus gemcitabine and S-1(GS)as the first-line treatment for advanced BTCs.At a one-sided significance level of 0.025,a total of 50 patients could provide 80%power to show the efficacy at targeted progression-free survival(PFS)rate at 6 months of 70%versus 40%for the combined treatment.This single-arm,phase II study enrolled 50 patients with advanced BTCs who previously received no systemic treatment.The regimen was as follows:toripalimab(240 mg,i.v.,d1),gemcitabine(1,000 mg/m2,i.v.,d1 and d8),and S-1(40–60 mg bid p.o.,d1–14,Q21d).The primary endpoint was progression-free survival.The secondary endpoints included overall survival(OS),objective response rate(ORR),duration of response(DOR),and safety.The associations between response with PDL1 expression,tumor mutational burden(TMB),and genetic variations were explored.Patients were enrolled from January 2019 to August 2020,with a median follow-up time of 24.0 months(IQR:4.3–31.0 months). | Wei Li Yueqi Wang Yiyi Yu Qian Li Yan Wang Chenlu Zhang Xiaojing Xu Xi Guo Yu Dong Yuehong Cui Qing Hao Lujia Huang Houbao Liu Tianshu Liu | 2022 | The Innovation2022，3，4： | 1 |
| 5 | Renewable energy from agro-residues in China: solid biofuels and biomass briquetting technology显示文摘 | Chen Longjian Xing Li Han Lujia | 2009 | Renewable and Sustainable Energy Reviews2009，13，12： | 1 |
| 6 | The development of agro-residue densified fuel in China based on energetics analysis 显示文摘 | Chen Longjian Xing Li Han Lujia | 2010 | Waste Management2010，30，5： | 1 |
| 7 | in vitro Antioxidant activity of protein hydrolysates prepared from corn gluten meal显示文摘 | LI Xiuxia HAN Lujia CHEN Longjian | 2008 | Journal of the Science of Food and Agriculture2008，88，9： | 1 |
| 8 | Renewable energy from agro-residues in China: Solid biofuels and biomass briquet- ting technology 显示文摘 | Longjian Chen Li Xing Lujia Han | 2009 | Renewable and Sustainable Energy Re-views2009，13，： | 1 |
| 9 | In vitro antioxidant activity of protein hydrolysates prepared from com glutenmeal显示文摘 | LI Xiuxia HAN Lujia CHEN Longjian | 2008 | Journal of the Science Food and Agriculture2008，88，9： | 1 |
| 10 | Increasing Momentum-Like Factors:A Method for Reducing Training Errors on Multiple GPUs显示文摘In distributed training,increasing batch size can improve parallelism,but it can also bring many difficulties to the training process and cause training errors.In this work,we investigate the occurrence of training errors in theory and train ResNet-50 on CIFAR-10 by using Stochastic Gradient Descent(SGD) and Adaptive moment estimation(Adam) while keeping the total batch size in the parameter server constant and lowering the batch size on each Graphics Processing Unit(GPU).A new method that considers momentum to eliminate training errors in distributed training is proposed.We define a Momentum-like Factor(MF) to represent the influence of former gradients on parameter updates in each iteration.Then,we modify the MF values and conduct experiments to explore how different MF values influence the training performance based on SGD,Adam,and Nesterov accelerated gradient.Experimental results reveal that increasing MFs is a reliable method for reducing training errors in distributed training.The analysis of convergent conditions in distributed training with consideration of a large batch size and multiple GPUs is presented in this paper. | Yu Tang Zhigang Kan Lujia Yin Zhiquan Lai Zhaoning Zhang Linbo Qiao Dongsheng Li | 2022 | Tsinghua Science and Technology2022，27，1： | 1 |
| 11 | Renewable energy from agro-residues in China: Solid biofuels and biomass briquet- ting technology 显示文摘 | Longjian Chen Li Xing Lujia Han | 2009 | Renewable and Sustainable Energy Re- views2009，13，： | 1 |
| 12 | Crosslinking and functionalization of acellular patches via the self-assembly of copper@tea polyphenol nanoparticles显示文摘Decellularization is a promising technique to produce natural scaffolds for tissue engineering applications.However,non-crosslinked natural scaffolds disfavor application in cardiovascular surgery due to poor biomechanics and rapid degradation.Herein,we proposed a green strategy to crosslink and functionalize acellular scaffolds via the self-assembly of copper@tea polyphenol nanoparticles(Cu@TP NPs),and the resultant nanocomposite acellular scaffolds were named as Cu@TP-dBPs.The crosslinking degree,biomechanics,denaturation temperature and resistance to enzymatic degradation of Cu@TP-dBPs were comparable to those of glutaraldehyde crosslinked decellularized bovine pericardias(Glut-dBPs).Furthermore,Cu@TP-dBPs were biocompatible and had abilities to inhibit bacterial growth and promote the formation of capillary-like networks.Subcutaneous implantation models demonstrated that Cu@TP-dBPs were free of calcification and allowed for host cell infiltration at Day 21.Cardiac patch graft models confirmed that Cu@TP-dBP patches showed improved ingrowth of functional blood vessels and remodeling of extracellular matrix at Day 60.These results suggested that Cu@TP-dBPs not only had comparable biomechanics and biostability to Glut-dBPs,but also had several advantages over Glut-dBPs in terms of anticalcification,remodeling and integration capabilities.Particularly,they were functional patches possessing antibacterial and proangiogenic activities.Thesematerial properties and biological functionsmade Cu@TP-dBPs a promising functional acellular patch for cardiovascular applications. | Qin Li Yuan Gao Jiajun Zhang Yangfeng Tang Yangyong Sun Lujia Wu Hao Wu Meifang Shen Xiaohong Liu Lin Han Zhiyun Xu | 2022 | Regenerative Biomaterials2022，9，1： | 1 |
| 13 | in vitro antioxidant activity of protein hydrolysates prepared from corn gluten meal显示文摘 | LI Xiuxia HAN Lujia CHEN Longjian | 2008 | Journal of the Science of Food and Agriculture2008，88，9： | 1 |
| 14 | in vitro antioxidant activity of protein hydrolysates prepared from corn gluten meal显示文摘 | LI Xiuxia HAN Lujia CHEN Longiian | 2008 | J Sci Food Agric2008，88，9： | 1 |
| 15 | In vitro Antioxidant activity of protein hydrolysates prepared from corn gluten meal显示文摘 | LI Xiuxia HAN Lujia CHEN Longjian | 2008 | Journal of the Science of Food and Agriculture2008，88，9： | 1 |
| 16 | The application of artificial intelligence and radiomics in lung cancer显示文摘Lung cancer is one of the most leading causes of death throughout the world,and there is an urgent requirement for the precision medical management of it.Artificial intelligence(AI)consisting of numerous advanced techniques has been widely applied in the field of medical care.Meanwhile,radiomics based on traditional machine learning also does a great job in mining information through medical images.With the integration of AI and radiomics,great progress has been made in the early diagnosis,specific characterization,and prognosis of lung cancer,which has aroused attention all over the world.In this study,we give a brief review of the current application of AI and radiomics for precision medical management in lung cancer. | Yaojie Zhou Xiuyuan Xu Lujia Song Chengdi Wang Jixiang Guo Zhang Yi Weimin Li | 2020 | Precision Clinical Medicine2020，3，3： | 1 |
| 17 | Renewable energy from agro-residues in China: solid biofuels and biomass briquet- ting technology 显示文摘 | Chen Eongjian Xing Li Han Lujia | 2009 | Renewable and Sustainable Energy Re- views2009，13，9： | 1 |
| 18 | In vitro Antioxidant activity of protein hydrolysates prepared from corn gluten meal显示文摘 | LI Xiuxia HAN Lujia CHEN Longjian | 2008 | Journal of the Science of Food and Agriculture2008，88，9： | 1 |
| 19 | Effect of enzymatic treatment of corn gluten meal on lutein, zeaxanthin and B-cryptoxanthin extraction显示文摘 | LI Xiuxia HAN Lujia | 2009 | Journal of Food Process Engineering2009，32，： | 1 |
| 20 | in vitro antioxidant activity of protein hydrolysates prepared from corn gluten meal显示文摘 | LI Xiuxia HAN Lujia CHEN Longjian | 2008 | Journal of the Science of Food and Agriculture2008，88，： | 1 |
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