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| 1 | Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal显示文摘Primary neoplasms arising in the anal canal are relatively unusual.In particular, adenomas and adenocarcinomas are distinctly rare entities in this region.We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy.This is the case of an octogenarian man with a several year history of hemorrhoids and intermittent rectal bleeding, more recently complaining of continuous hematochezia.Examination revealed a blood-covered pedunculated mass with a long stalk protruding from the anus.The lesion was amputated at the bedside.Microscopic evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous adenoma.This was further evaluated under anesthesia and complete excision of distal anal tissue was performed.Our report is the f irst describing the possible malignant degeneration of a villous adenoma in the anal canal. | Marni Colvin Aris Delis Erika Bracamonte Hugo Villar Luis R Leon Jr | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 2 | STAT3 as a therapeutic target in head and neck cancer 显示文摘 | Leeman R J Lui VW Grandis JR | 2006 | Expert Opin Biol Ther2006，6，3： | 1 |
| 3 | STAT3 as a therapeutic target in head and neck cancer显示文摘 | Leeman RJ Lui VW Grandis JR | 2006 | Expert Opin Biol Ther2006，6，3： | 1 |
| 4 | Application of the discrete ele- ment method for modeling of rock crack propagation and coalescence in the step-path failure mechanism显示文摘 | Luis Arnaldo Mejfa Camones Eurtpedes do Amaral Vargas Jr Rodri- go Peluci de Figueiredo | 2013 | Engineering Geology2013，153，2： | 1 |
| 5 | Ruptured dissecting cerebral aneurysms in young people: report of three cases 显示文摘 | Stefano P Luis JR Marta C | 2010 | Acta Neurochirurgiea2010，9，152： | 1 |
| 6 | STAT3 as a therapeutic target in head and neck cancer显示文摘 | Leeman R J Lui VW Grandis JR | 2006 | Expert Opin Biol Ther2006，6，3： | 1 |
| 7 | Chronic obstructive pulmonary disease显示文摘 | Luis AS Pina J Vieira JR | 2001 | Acta Med Port2001，14，： | 1 |
| 8 | Radiation injury to the heart显示文摘 | Steward JR Luis F Fajardo LF | 1995 | Int J Radiat Oncol Biol Phys1995，31，： | 1 |
| 9 | Simulation of nozzle clogging during the continuous casting of aluminum-killed steel显示文摘 | LUIS TRUEBA JR KENT D | 2006 | AIST Transaction2006，2006，： | 1 |
| 10 | STAT3 as a therapeutic target in head and neck cancer 显示文摘 | Leeman RJ Lui VW Grandis JR | 2006 | Expert Opin Biol Ther2006，6，3： | 1 |
| 11 | Testosterone replacement maintains smooth muscle content in the corpus cavernosum of orchiectomized rats显示文摘Objective:To evaluate the effects of testosterone(T)on the maintenance of corpus cavernosum(CC)structure and apoptosis.Methods:Animals were divided into three groups:sham operation group(n Z 8)underwent sham operation;Orchiectomized(Orchiec)t oily vehicle group(n Z 8)underwent bilateral orchiectomy and received a single dose of oily vehicle by intramuscular injection(i.m.)30 days after orchiectomy;and Orchiec t T group(n Z 8)underwent bilateral orchiectomy and received a single dose of T undecanoate 100 mg/kg i.m.30 days after the surgery.Animals were euthanized 60 days after the beginning of the experiment with an anesthetic overdose of ketamine and xylazine.Blood samples and penile tissue were collected on euthanasia. | Graziele Halmenschlager Ernani Luis Rhoden Gabriela Almeida Motta Lucas Sagrillo Fagundes Jorge Luiz Medeiros Jr Rosalva Meurer Claudia Ramos Rhoden | 2017 | Asian Journal of Urology2017，4，4： | 1 |
| 12 | Effect of calcium hydroxide, carbonate and sodium bicarbonate on water quality and zootechnical performance of shrimp Litopenaeus vannamei reared in bio-flocs technology ( BFT ) systems 显示文摘 | PLINIO S F LUiS H P WILSON W JR | 2011 | Aquaculture2011，321，12： | 1 |
| 13 | A study of the effect of high inlet solids loading on a cyclone separator pressure drop and separation efficiency 显示文摘 | Fabio Luis Fassani Leonardo Goldstein Jr | 2000 | Powder Technology2000，107，2000： | 1 |
| 14 | 后牙复合树脂直接修复[牙合]面边缘最佳效果的新技术显示文摘现代牙体美学修复材料的发展使充填体与牙齿几乎不可分辨。但是.这会导致窝洞边缘不清.充填材料超出窝洞的现象。本文针对这一问题,提出一种新的后牙耠面直接粘接修复技术.可以显著降低充填材料超出洞缘线的现象。 | Luis Henrique Schlichting Sylvio Monteiro Jr Luiz Narciso Baratieri 侯晓玫(译) 董雯(审) | 2009 | 中国口腔医学继续教育杂志2009，，1： | 1 |
| 15 | Multiparametric MRI reporting using Prostate Imaging Reporting and Data System version 2.0 (PI-RADSv2) retains clinical efficacy in a predominantly post-biopsy patient population显示文摘Objective:To evaluate the efficacy of multiparametric magnetic resonance imaging(mp-MRI)using Prostate Imaging Reporting and Data System version 2.0(PI-RADSv2)definitions in detecting organ-confined prostate cancer.Methods:All patients who underwent radical prostatectomy between January 1,2014 and December 30,2014 were identified.All underwent mp-MRI within 180 days before surgery.Those with prior pelvic irradiation or androgen deprivation therapy were excluded.Fully embedded,whole-mount histopathology was centrally reviewed and correlated with imaging for tumour location,Gleason score(GS)and stage.Results:There were 39 patients included,of which 35(90%)had mp-MRI done post-biopsy.A total of 93 cancer foci were identified on whole-mount pathology,of which mp-MRI detected 63(68%).Of those detected by mp-MRI,14 were PI-RADS 3(n=6 for GS 6,n=8 for GS 7,no GS≥8)and 49 were PI-RADS 4e5(nZ7 for GS 6,nZ33 for GS 7,and nZ9 for GS≥8).There were 30(32%)cancer foci missed by mp-MRI(n=15 for GS 6,n=13 for GS 7 and n=2 for GS≥8).A lesion classified as PI-RADS 4e5 predicted a higher grade cancer on pathology as compared to PI-RADS 3(for GS 7 lesions,odds ratio[OR]=3.53,95%CI:0.93e13.45,p=0.064).The mp-MRI size detection limit was 20 mm2 and 100 mm2 for 50%and 75%probability of cancer,respectively.In associating with radiological and pathologic stage,the weighted Kappa value was 0.69(p<0.0001).The sensitivity and positive predictive values for this study were 68%(95%CI:57%e77%)and 78%(95%CI:67%e86%),respectively.Conclusion:In this predominantly post-biopsy cohort,mp-MRI using PI-RADSv2 reporting has a reasonably high diagnostic accuracy in detecting clinically significant prostate cancer. | Edwin Jonathan Aslim Yan Mee Law Puay Hoon Tan John Carson Allen Jr Lionel Tim-Ee Cheng Viswanath Anand Chidambaram Li Yan Khor Benjamin Yongcheng Tan Ernest Wencong Eu Christopher Wai Sam Cheng John Shyi Peng Yuen Henry Sun Sien Ho Lui Shiong Lee | 2019 | Asian Journal of Urology2019，6，3： | 1 |
| 16 | STAT3 as a therapeutic target in head and neck cancer显示文摘 | Leeman RJ Lui VW Grandis JR | 2006 | Expert Opin Biol Ther2006，6，3： | 1 |
| 17 | STAT3 as a therapeutic target in head and neck cancer显示文摘 | Leeman RJ Lui VW Grandis JR | 2006 | Expert Opin Biol Ther2006，6，3： | 1 |
| 18 | Systemic production of IL-12 by naked DNA mediated gene transfer:toxicity and attenuation of transgene expression in vivo显示文摘 | Falo L D Jr Huang L | 2001 | J Gene Med2001，3，4： | 1 |
| 19 | The effects of aging in the medial genicukate nucleus:a comparison with the inferior colliculus and auditory cortex显示文摘 | Mendelson JR Lui B | 2004 | Hear Res2004，191，12： | 1 |
| 20 | The decoupling of ceo pay and performance: an agency theory perspective 显示文摘 | TOSI HENRY L JR GOMEZ MEJIA LUIS R | 1989 | Administrative Science Quarterly1989，34，2： | 1 |
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