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| 1 | Performance of liver stiffness measurements by transient elastography in chronic hepatitis显示文摘AIM:To compare results of liver stiffness measurements by transient elastography(TE) obtained in our patients population with that used in a recently published meta-analysis.METHODS:This was a single center cross-sectional study.Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled.TE was carried out by using FibroScan(Echosens,Paris,France).Liver biopsy was performed on the same day as TE,as day case procedure.Fibrosis was staged according to the Metavir scoring system.The diagnostic performance of TE was assessed by using receiver operating characteristic(ROC) curves and the area under the ROC curve analysis.RESULTS:Two hundred and fifty-two patients met the inclusion criteria.Six(2%) patients were excluded due to unreliable TE measurements.Thus,246(171 men and 75 women) patients were analyzed.One hundred and ninety-five(79.3%) patients had chronic hepatitis C,41(16.7%) had chronic hepatitis B,and 10(4.0%) were coinfected with human immunodeficiency virus.ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa forF ≥ 2;7.9 kPa forF ≥ 3;9.6 kPa for F = 4 in all patients(n = 246),and as high as 6.9 kPa for F ≥ 2;7.3 kPa for F ≥ 3;9.3 kPa for F = 4 in patients with hepatitis C(n = 195).Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2;9.6 kPa for F ≥ 3;12.2 kPa for F = 4 in all patients(n = 246),and as high as 7.0 kPa forF ≥ 2;9.3 kPa forF ≥ 3;12.3 kPa forF = 4 in patients with hepatitis C(n = 195).CONCLUSION:The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies. | Giovanna Ferraioli Carmine Tinelli Barbara Dal Bello Mabel Zicchetti Raffaella Lissandrin Gaetano Filice Carlo Filice Elisabetta Above Giorgio Barbarini Enrico Brunetti Willy Calderon Marta Di Gregorio Roberto Gulminetti Paolo Lanzarini Serena Ludovisi Laura Maiocchi Antonello Malfitano Giuseppe Michelone Lorenzo Minoli Mario Mondelli Stefano Novati Savino FA Patruno Alessandro Perretti Gianluigi Poma Paolo Sacchi Domenico Zanaboni Marco Zaramella | 2013 | World Journal of Gastroenterology2013，19，1： | 18 |
| 2 | 腹腔镜评估晚期卵巢癌患者能否行满意的肿瘤细胞减灭术:初步研究 | Fagotti A. Fanfani F. Ludovisi M. G.Scambia 石菁菁 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，7： | 4 |
| 3 | A phase Ⅱ,single–arm multicenter study of low–dose rituximab for refractory mixed cryoglobulinemia secondary to hepatitis C virus infection显示文摘 | VisentiniM LudovisiS PetrarcaA | 2011 | Autoimmun Rev2011，10，71： | 1 |
| 4 | Phase trial of gemc-itabine compared with pegylated liposomal doxorubicin in progressiveor recurrent ovarian oancer显示文摘 | Ferrandina G Ludovisi M Lomsso D | 2008 | J Clin Oncol2008，26，6： | 1 |
| 5 | Role of laparoscopy to assess the chance of optimal cytoreductive surgery in advanced ovarian cancer: a pilot study显示文摘 | Fagotti A Fanfani F Ludovisi M | 2005 | Gynecol Oncol2005，96，3： | 1 |
| 6 | Role of laparoscopy to assess the chance of optimal cytoreductive surgery in advanced ovarian cancer: a pilot study显示文摘 | Fagotti A Fanfani F Ludovisi M | 2005 | Gynecol Oncol2005，96，3： | 1 |
| 7 | Transvaginal ul-trasonography and magnetic resonance imaging for assess-ment of presence,size and extent of invasive cervical canc-er显示文摘 | Testa AC Ludovisi M Manfredi R | 2009 | Ultrasound Obstet Gynecol2009，34，3： | 1 |
| 8 | Use of thermodynamic indices asecological indicators of the development state of lake ecosystems显示文摘 | LUDOVISI A POLETTI A | 2003 | Ecological Modeling2003，159，23： | 1 |
| 9 | Use of thermodynamic indices as ecological indicatorsof the development state of lake ecosystems : Specific dissipation显示文摘 | Ludovisi A | 2006 | Ecological Indicators2006，6，1： | 1 |
| 10 | Role of laparoscopy to assess the chance of optimal cytoreductive surgery in advanced ovarian cancer:a pilot study显示文摘 | Fagotti A Fanfani F Ludovisi M | 2005 | Gynecol Oncol2005，96，3： | 1 |
| 11 | Unique immunological profile in patients with COVID-19显示文摘The relationship between severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and host immunity is poorly understood.We performed an extensive analysis of immune responses in 32 patients with severe COVID-19,some of whom succumbed A control population of healthy subjects was included.Patients with COVID-19 had an altered distribution of peripheral blood lymphocytes,with an increased proportion of mature natural killer(NK)cells and low T-cell numbers.NK cells and CD8^(+)T cells overexpressed T-cellimmunoglobulin and mucin domain-3(TIM-3)and CD69.NK cell exhaustion was attested by increased frequencies of programmed cell death protein 1(PD-1)positive cells and reduced frequencies of natural killer group 2 member D(NKG2D)-,DNAX accessory molecule-1(DNAM-1)-and sialic acid-binding Ig-like lectin 7(Siglec-7)-expressing NK cells,associated with a reduced ability to secrete interferon(IFN)γ.Patients with poor outcome showed a contraction of immature CD56^(bright) and an expansion of mature CD57^(+)F_(CEI)Rlγ^(eng) adaptive NK cells compared to survivors.Increased serum levels of IL-6 were also more frequently identified in deceased patients compared to survivors.Of note,monocytes secreted abundant quantities of IL-6,IL-8,and IL-1β which persisted at lower levels several weeks after recovery with concomitant normalization of CD69,PD-1 and TIM-3 expression and restoration of CD8^(+)T cell numbers.A hyperactivated/exhausted immune response dominate in severe SARS-CoV-2 infection,probably driven by an uncontrolled secretion of inflammatory cytokines by monocytes.These findings unveil a unique immunological profile in COVID-19 patients that will help to design effective stage-specific treatments for this potentially deadly disease. | Stefania Varchetta Dalila Mele Barbara Olivier Stefania Mantovani Serena Ludovisi Antonella Cerino Raffaele Bruno Alberto Castelli Mario Mosconi Marco Vecchia Silvia Roda Michele Sachs Catherine Klersy Mario U.Mondelli | 2021 | Cellular & Molecular Immunology2021，18，3： | 1 |
| 12 | Feline leishmaniosis due to Leishmania infantum in Italy显示文摘 | Alessandro Poli Francesca Abramo Paola Barsotti Stefano Leva Marina Gramiccia Alessandra Ludovisi Francesca Mancianti | 2002 | Veterinary Parasitology2002，，3： | 1 |
| 13 | Gemcitabine and liposomal doxorubicin in the salvage treatment of ovarian cancer:Updated results and long-term survival显示文摘 | Ferrandina G Paris I Ludovisi M | 2005 | Gynecol Oncol2005，98，2： | 1 |
| 14 | Phase Ⅲ trial of gemcitabine compared with pegylated liposomal doxorubicin in progressive or recurrent ovarian cancer显示文摘 | Ferrandina G Ludovisi M Lorusso D | 2008 | J Clin Oncol2008，26，6： | 1 |
| 15 | Role of laparoscopy to assess the chance of optimal cytoreductive surgery in advanced ovarian cancer: a pilot study显示文摘 | Fagotti A Fanfani F Ludovisi M | 2005 | Gynecol Oncol2005，96，3： | 1 |
| 16 | Role of laparoscopy to assess the chance of optimal cytoreductive surgery in advanced ovarian cancer:a pilot study显示文摘 | Fagotti A Fanfani F Ludovisi M | 2005 | Gynecol Oncol2005，96，3： | 1 |
| 17 | Cryptosporidium parvum-specific CD4 Th1 cells from sensitized donors responding to both fractionated and recombinant antigenic proteins 显示文摘 | Gomez Morales MA Mele R Ludovisi A | 2004 | Infect Immun2004，72，3： | 1 |
| 18 | Use of thermodynamic indices as ecological indicators of the development stale of lake ecosystems显示文摘 | Ludovisi A Poletti A | 2003 | Ecological Modelling2003，159，23： | 1 |
| 19 | Gemcitabine and liposomal doxorubicin in the salvage treatment of ovarian cancer: updated results and longterm survival 显示文摘 | Ferrandina G Paris I Ludovisi M | 2005 | Gyneeol Oneol2005，98，2： | 1 |
| 20 | Lymph node involvement in locally advanced cervical cancer patients ad-ministered preoperative chemoradiation versus chemotherapy 显示文摘 | Ferrandina G Distefano M Ludovisi M | 2007 | Ann Surg Onco12007，14，3： | 1 |
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