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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation显示文摘 | Luana S. Nunes José T.P. Barbosa Andréa P. Fernandes Valfredo A. Lemos Walter N.L. dos Santos Maria Gra?as A. Korn Leonardo S.G. Teixeira | 2011 | Food Chemistry2011，，2： | 4 |
| 3 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 4 | Client-level predictors of treatment engagement,outcome and dropout:moving beyond demographics显示文摘Background Despite the availability of evidence-based treatments for posttraumatic stress disorder(PTSD),significant heterogeneity in the effectiveness of PTSD treatment persists,especially in community settings.Client demographics used to understand this variability in treatment outcome and dropout have yielded mixed results.Despite increasing evidence for the importance of attending to treatment engagement in community settings,few studies have explored client-level predictors.Aim The purpose of this study is to explore client-level predictors of treatment outcome and dropout beyond client demographics,and to identify client-level predictors of treatment engagement in community settings.Method Secondary data analysis was conducted with data collected as part of an implementation-effectiveness hybrid study of cognitive processing therapy(CPT)for PTSD in a diverse community healthcentre.Providers(n=19)treated(n=52)clients as part of their routine clinical care.Non-demographic client-level predictors included barriers to treatment,quality of life,session-level language and employment history assessed at baseline.Treatment engagement included number of weeks in the study,number of sessions with repeated CPT content,number of unique CPT sessions attended,frequency of session attendance and consistency of session attendance.Results Results showed language as a significant predictor of treatment engagement.There were significant differences between Spanish and English-speaking clients,with the former having a tendency to repeat more session content than the latter(β=1.4 sessions,p=0.003),and also less likely to attend treatment frequently(r=0.62,p=0.009)and consistently(r=0.57,p=0.027)if high logistical and financial barriers were endorsed.Irrespective of language,clients who reported high quality of life at baseline were less likely to repeat CPT session content(β=-0.3,p=0.04),and those with increased baseline barriers to treatment had deceleration in PTSD symptom improvement over time(β=-0.62,p<0.05).In terms of treatment engagement moderators impacting treatment outcome,clients who repeated more session content were more likely to complete treatment(0R=1.84,p=0.037).Conclusion Identification of client-level predictors of treatment engagement,outcome and dropout is essential to optimise treatment,particularly in community settings. | Soo-jeong Youn Margaret-Anne Mackintosh Shannon Wiltsey Stirman Kay lie A Patrick Yesenia Aguilar Silvan Anna D Bartuska Derri L Shtasel Luana Marques | 2019 | General Psychiatry2019，32，6： | 2 |
| 5 | GIBBS: isothermal-isobaric thermodynamics of solids from energy curves using a quasiharmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，1： | 1 |
| 6 | Computer PhysicsCommunications显示文摘 | Otero-de-la-Roza A Victor Luana | 2011 | 2011,182: 17082011，182，： | 1 |
| 7 | GIBBS:Isothermal-isobaric Thermodynamics of Solids from Energy Curves Using a Quasiharmonic Debye Model显示文摘 | BLANCO M A FRANCISCO E LUANA V | | 0，，01： | 1 |
| 8 | Influence of norbixin on plasma cholesteroassociated lipoproteins,plasma arylesterase/paraoxonase activity and hepatic lipid peroxidation of Swiss mice on a high fat diet显示文摘 | Andressa A A Santos Márcia V G Silva Luana T A Guerreiro | 2002 | Food Chemistry2002，77，： | 1 |
| 9 | GIBBS:Isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，1： | 1 |
| 10 | Proteasome inhibitors synergize with tumor necrosis factor-relate apoptosis-indured ligand to induce anaplastic thyroid carcinoma cell death显示文摘 | Concetta C Luana A Raffaella G | 2007 | J Clin Endocrinol Metab2007，92，5： | 1 |
| 11 | GIBBS:isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，： | 1 |
| 12 | GIBBS: isothermalisobaric thermodynamics of solids from energy curves using a quasi - harmonic Dybcy model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，： | 1 |
| 13 | GIBBS: isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | BLANCO M A FRANCISCO E LUANA V | 2004 | Computer Physics Communications2004，158，1： | 1 |
| 14 | GIBBS: Isothermal-Isobaric Thermodynamics of Solids from Energy Curves Using a Quasi-harmonic Debye Model 显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Comm2004，158，1： | 1 |
| 15 | Surface improvement of fused modelingpartd of barrel finishing显示文摘 | Boschetto A Bottini Luana | 2015 | Rapid Prototyping Journal2015，21，68： | 1 |
| 16 | GIBBS: isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | ComputPhys Commun2004，158，1： | 1 |
| 17 | GIBBS: Isothermal-i-sobaric thermodynamics of solids from energy curves using aquasi-harmonic Debye model 显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，1： | 1 |
| 18 | Gibbs:isother- mal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | Blaneo M A Francisco E Luana V | 2004 | Comp Phys Commun2004，158，： | 1 |
| 19 | GIBBS : i- sothermal-isobaric thermodynamics of solids from energy curves using a quasiharmonic Debye model显示文摘 | BLANCO M A FRANCISCO E LUANA V | 2004 | Computer Physics Communications2004，158，1： | 1 |
| 20 | GIBBS: Isothermal-isobaric thermodynamics of solids from energy curves using a quasiharmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，1： | 1 |
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